Biological activities of HAP46/BAG-1. The HAP46/BAG-1 protein: Regulator HSP70 chaperones, DNA-binding protein and stimulator of transcription

EMBO Reports

Volumn 5, Issue 2, 2004, Pages 148-153

  Gehring, Ulrich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Bcl 2 associated athanogene BAG 1; DNA binding; HSP70 HSC70 molecular chaperones; HSP70 HSP70 associating protein HAP46; Transcriptional stimulation

Indexed keywords

ADENOSINE TRIPHOSPHATE; BAG 1 PROTEIN; CHAPERONE; DNA BINDING PROTEIN; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; ISOPROTEIN; PROTEIN HAP46; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BINDING SITE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; COMPLEX FORMATION; DNA RESPONSIVE ELEMENT; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; TRANSCRIPTION INITIATION;

ANIMALS; CARRIER PROTEINS; CELL SURVIVAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NEOPLASMS; PROTEIN FOLDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, STEROID; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; UBIQUITIN; UP-REGULATION;

MAMMALIA;

EID: 1642527873     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400083     Document Type: Review

References (49)

1. Adachi M, Sekiya M, Torigoe T, Takayama S, Reed JC, Miyazaki T, Minami Y, Taniguchi T, Imai K (1996) Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor βc chain. Blood 88: 4118-4123
2. Alberti S, Demand J, Esser C, Emmerich N, Schild H, Höhfeld J (2002) Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome. J Biol Chem 277: 45920-45927
3. Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C, Comoglio PM (1996) HGF receptor associates with the anti-apoptotic protein Bag-1 and prevents cell death. EMBO J 15: 6205-6212
4. Brehmer D, Rüdiger S, Gässler CS, Klostermeier D, Packschies L, Reinstein J, Mayer MP, Bukau B (2001) Tuning of chaperone activity of hsp70 proteins by modulation of nucleotide exchange. Nat Struct Biol 8: 427-432
5. Briknarová K et al (2001) Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein. Nat Struct Biol 8: 349-352
6. Brive L, Takayama S, Briknarová K, Homma S, Ishida SK, Reed JC, Ely KR (2001) The carboxy-terminal lobe of hsc70 ATPase domain is sufficient for binding BAG1. Biochem Biophys Res Commun 289: 1099-1105
7. Crocoll A, Blum M, Cato AC (2000) Isoform-specific expression of BAG-1 in mouse development. Mech Dev 91: 355-359
8. Cutress RI et al (2003) The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription. Oncogene 22: 4973-4982
9. Ding Z, Yang X, Pater A, Tang S-C (2000) Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug-resistant cells. Biochem Biophys Res Commun 270: 415-420
10. Froesch BA, Takayama S, Reed JC (1998) BAG-1L protein enhances androgen receptor function. J Biol Chem 273: 11660-11666
11. Gässler CS, Wiederkehr T, Brehmer D, Bukau B, Mayer MP (2001) Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor. J Biol Chem 276: 32538-32544
12. Gebauer M, Zeiner M, Gehring U (1997) Proteins interacting with the molecular chaperone hsp70/hsc7O: Physical associations and effects on refolding activity. FEBS Lett 417: 109-113
13. Gebauer M, Zeiner M, Gehring, U (1998) Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70. Mol Cell Biol 18: 6238-6244
14. Guzey M, Takayama S, Reed JC (2000) BAG1L enhances trans-activation function of the vitamin D receptor. J Biol Chem 275: 40749-40756
15. Höhfeld J, Jentsch S (1997) GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J 16: 6209-6216
16. Hung WJ, Roberson RS, Taft J, Wu DY (2003) Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. Mol Cell Biol 23: 3477-3486
17. Kitada S, Zapata JM, Andreeff M, Reed JC (2000) Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 96: 393-397
18. Knee DA, Froesch BA, Nuber U, Takayama S, Reed JC (2001) Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity. J Biol Chem 276: 12718-12724
19. Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato ACB (1998) RAP46 is a negative regulator of glucocorticoid receptor action and hormone induced apoptosis. J Biol Chem 273: 14620-14625
20. Liu R, Takayama S, Zheng Y, Froesch B, Chen G, Zang X, Reed JC, Zang XK (1998) Interaction of BAG-1 with retinoic receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J Biol Chem 273: 16985-16992
21. Lüders J, Demand J, Höhfeld J (2000a) The ubiquitin-related BAG-1 provides a link between the molecular chaperones hsc70/hsp70 and the proteasome. J Biol Chem 775: 4613-4617
22. Lüders J, Demand J, Papp O, Höhfeld J (2000b) Distinct isoforms of the cofactor BAG-1 differentially affect hsc70 chaperone function. J Biol Chem 275: 14817-14823
23. Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC (1998) p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: Suppression by BAG-1. EMBO J 17: 2736-2747
24. Mayer MP, Brehmer D, Gassler CS, Bukau B (2001) Hsp70 chaperone machines. Adv Protein Chem 59: 1-44
25. Niyaz Y, Zeiner M, Gehring U (2001) Transcriptional activation by the human Hsp70-associating protein Hap50. J Cell Sci 114: 1839-1845
26. Niyaz Y, Frenz I, Petersen G, Gehring U (2003) Transcriptional stimulation by the DNA binding protein Hap46/BAG-1M involves hsp70/hsc70 molecular chaperones. Nucleic Acids Res 31: 2209-2216
27. Nollen EAA, Brunsting JF, Song J, Kampinga, HH, Morimoto RI (2000) Bag-1 functions in vivo as a negative regulator of hsp70 chaperone activity. Mol Cell Biol 20: 1083-1088
28. Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Jochimiak A (1999) Structure of a new crystal form of human hsp70 ATPase domain. Acta Crystallogr 55: 1105-1107
29. Packham G, Brimmel M, Cleveland JL (1997) Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. Biochem J 328: 807-813
30. Petersen G, Hahn C, Gehring U (2001) Dissection of the ATP binding domain of the chaperone hsc70 for interaction with the cofactor Hap46. J Biol Chem 276: 10178-10184
31. Schmidt U, Wochnik GM, Rosenhagen MC, Young JC, Hartl FU, Holsboer F, Rein T (2003) Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J Biol Chem 278: 4926-4931
32. Schneikert J, Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato ACB (2000) Hsp70 - RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor. EMBO J 19: 6508-6516
33. Sondermann H, Scheufler C, Schneider C, Höhfeld J, Hartl F-U, Moarefi I (2001) Structure of a Bag/hsc70 complex: Convergent functional evolution of hsp70 nucleotide exchange factors. Science 291: 1553-1557
34. Song J, Takeda M, Morimoto RI (2001) Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biol 3: 276-282
35. Takahashi N, Yanagihara M, Ogawa Y, Yamanoha B, Andoh T (2003) Downregulation of Bcl-2-interacting protein BAG-1 confers resistance to anticancer drugs. Biochem Biophys Res Commun 301: 798-803
36. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (1995) Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity. Cell 80: 279-284
37. Takayama S, Kochel K, Irie S, Inazawa J, Abe T, Sato T, Druck T, Huebner K, Reed JC (1996) Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. Genomics 35: 494-498
38. Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC (1997) BAG-1 modulates the chaperone activity of hsp70/hsc70. EMBO J 16: 4887-4896
39. Takayama S et al (1998) Expression and location of Hsp70/Hsc-binding antiapoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. Cancer Res 58: 3116-3131
40. Takayama S, Xie Z, Reed JC (1999) An evolutionarily conserved family of hsp70/hsc70 molecular chaperone regulators. J Biol Chem 274: 781-786
41. Terada K, Mori M (2000) Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem 275: 24728-24734
42. Townsend PA, Cutress RI, Sharp A, Brimmell M, Packham G (2003a) BAG-1: A multifunctional regulator of cell growth and survival. Biochim Biophys Acta 1603: 83-98
43. Townsend PA, Cutress RI, Sharp A, Brimmell M, Packham G (2003b) BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway. Cancer Res 63: 4150-4157
44. Witcher M, Yang X, Pater A, Tang S-C (2001) BAG-1 p50 isoform interacts with the vitamin D receptor and its cellular overexpression inhibits the vitamin D pathway. Exp Cell Res 265: 167-173
45. Yang X, Chernenko G, Hao Y, Ding Z, Pater MM, Pater A, Tang S-C (1998) Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. Oncogene 17: 981-989
46. Yang X, Pater A, Tang SC (1999) Cloning and characterization of the human BAG-1 gene promoter: Upregulation by tumor-derived p53 mutants. Oncogene 18: 4546-4553
47. Zeiner M, Gehring U (1995) A protein that interacts with members of the nuclear hormone receptor family: Identification and cDNA cloning. Proc Natl Acad Sci USA 92: 11465-11469
48. Zeiner M, Gebauer M, Gehring U (1997) Mammalian protein RAP46: An interaction partner and modulator of 70 kDa heat shock proteins. EMBO J 16: 5483-5490
49. Zeiner M, Niyaz Y, Gehring U (1999) The hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc Natl Acad Sci USA 96: 10194-10199