Down-regulation of Bcl-2-interacting protein BAG-1 confers resistance to anti-cancer drugs

Biochemical and Biophysical Research Communications

Volumn 301, Issue 3, 2003, Pages 798-803

  Takahashi, Noriko ^a,b   Yanagihara, Miyako ^a   Ogawa, Yuzi ^a   Yamanoha, Banri ^a   Andoh, Toshiwo ^a  

^a SOKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Anti cancer drugs; Apoptosis; BAG 1; Bcl 2; RNA interference

Indexed keywords

ANTINEOPLASTIC AGENT; BAG 1 PROTEIN; PROTEIN BCL 2; RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REDUCTION; STRESS; UTERINE CERVIX CARCINOMA;

TAKAYAMA;

EID: 0037436324     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00020-2     Document Type: Article

References (32)

1. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J.A., Reed J.C. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 80:1995;279-284.
2. Wang H.G., Takayama S., Rapp U.R., Reed J.C. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc. Natl. Acad. Sci. USA. 93:1996;7063-7068.
3. Bardelli A., Longati P., Albero D., Goruppi S., Schneider C., Ponzetto C., Comoglio P.M. HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. EMBO J. 15:1996;6205-6212.
4. Zeiner M., Gehring U. A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc. Natl. Acad. Sci. USA. 92:1995;11465-11469.
5. Takayama S., Bimston D.N., Matsuzawa S., Freeman B.C., Aime-Sempe C., Xie Z., Morimoto R.I., Reed J.C. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 16:1997;4887-4896.
6. Zeiner M., Gebauer M., Gehring U. Mammalian protein RAP46: an interaction partner and modulator of 70. kDa heat shock proteins EMBO J. 16:1997;5483-5490.
7. Hohfeld J., Jentsch S. GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J. 16:1997;6209-6216.
8. Hohfeld J. Regulation of the heat shock conjugate Hsc70 in the mammalian cell: the characterization of the anti-apoptotic protein BAG-1 provides novel insights. Biol. Chem. 379:1998;269-274.
9. Stuart J.K., Myszka D.G., Joss L., Mitchell R.S., McDonald S.M., Xie Z., Takayama S., Reed J.C., Ely K.R. Characterization of interactions between the anti-apoptotic protein BAG-1 and Hsc70 molecular chaperones. J. Biol. Chem. 273:1998;22506-22514.
10. Zeiner M., Niyaz Y., Gehring U. The Hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc. Natl. Acad. Sci. USA. 96:1999;10194-10199.
11. Nollen E.A., Brunsting J.F., Song J., Kampinga H.H., Morimoto R.I. BAG-1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Mol. Cell. Biol. 20:2000;1083-1088.
12. Takahashi N., Sasaki R., Takahashi J., Takayama S., Reed J.C., Andoh T. BAG-1M, an isoform of Bcl-2-interacting protein BAG-1, enhances gene expression driven by CMV promoter. Biochem. Biophys. Res. Commun. 286:2001;807-814.
13. Packham G., Brimmell M., Cleveland J.L. Mammalian cells express two differently localized BAG-1 isoforms generated by alternative translation initiation. Biochem. J. 328:1997;807-813.
14. Yang X., Chernenko G., Hao Y., Ding Z., Pater M.M., Pater A., Tang S.C. Human BAG-1/RAP46 protein is generated as four isoforms by alternative translation initiation and overexpressed in cancer cells. Oncogene. 17:1998;981-989.
15. Chen J., Xiong J., Liu H., Chernenko G., Tang S.C. Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line. Oncogene. 21:2002;7050-7059.
16. Konopleva M., Tari A.M., Estrov Z., Harris D., Xie Z., Zhao S., Lopez-Berestein G., Andreeff M. Liposomal Bcl-2 antisense oligonucleotides enhance proliferation, sensitize acute myeloid leukemia to cytosine-arabinoside, and induce apoptosis independent of other antiapoptotic proteins. Blood. 95:2000;3929-3938.
17. Cotter F.E. Antisense therapy of hematologic malignancies. Semin. Hematol. 36:1999;9-14.
18. Roth W., Grimmel C., Rieger L., Strik H., Takayama S., Krajewski S., Meyermann R., Dichgans J., Reed J.C., Weller M. BAG-1 and Bcl-2 gene transfer in malignant glioma: modulation of cell cycle regulation and apoptosis. Brain Pathol. 10:2000;223-234.
19. Naishiro Y., Adachi M., Okuda H., Yawata A., Mitaka T., Takayama S., Reed J.C., Hinoda Y., Imai K. BAG-1 accelerates cell motility of human gastric cancer cells. Oncogene. 18:1999;3244-3251.
20. Yang X., Hao Y., Ferenczy A., Tang S.C., Pater A. Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer. Exp. Cell Res. 247:1999;200-207.
21. Shindoh M., Adachi M., Higashino F., Yasuda M., Hida K., Nishioka T., Ono M., Takayama S., Reed J.C., Imai K., Totsuka Y., Kohgo T. BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. Oral Oncol. 36:2000;444-449.
22. Kikuchi R., Noguchi T., Takeno S., Funada Y., Moriyama H., Uchida Y. Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas. Br. J. Cancer. 87:2002;1136-1139.
23. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
24. Hannon G.J. RNA interference. Nature. 418:2002;244-251.
25. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47:1987;936-942.
26. Song J., Takeda M., Morimoto R.I. BAG-1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat. Cell Biol. 3:2001;276-282.
27. Sawitzki B., Amersi F., Ritter T., Fisser M., Shen X.D., Ke B., Busuttil R., Volk H.D., Kupiec-Weglinski J.W. Upregulation of BAG-1 by ex vivo gene transfer protects rat livers from ischemia/reperfusion injury. Hum. Gene Ther. 13:2002;1495-1504.
28. Luders J., Demand J., Papp O., Hohfeld J. Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function. J. Biol. Chem. 275:2000;14817-14823.
29. Niyaz Y., Zeiner M., Gehring U. Transcriptional activation by the human Hsp70-associating protein Hap50. J. Cell Sci. 114:2001;1839-1845.
30. Crocoll A., Blum M., Cato A.C. Isoform-specific expression of BAG-1 in mouse development. Mech. Dev. 91:2000;355-359.
31. Adjei A.A. Blocking oncogenic Ras signaling for cancer therapy. J. Natl. Cancer Inst. 93:2001;062-74.
32. Macpherson G.R., Ng S.S., Lakhani N.J., Price D.K., Venitz J., Figg W.D. Antiangiogenesis therapeutic strategies in prostate cancer. Cancer Metastasis Rev. 21:2002;93-106.