Interleukin-10 (IL-10) augments allograft arterial disease: Paradoxical effects of IL-10 in vivo

American Journal of Pathology

Volumn 155, Issue 6, 1999, Pages 1929-1939

  Furukawa, Yutaka ^a   Becker, Gerold ^a   Stinn, Jennifer L ^a   Shimizu, Koichi ^a   Libby, Peter ^a   Mitchell, Richard N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10;

ALLOGRAFT; ANIMAL CELL; ANTIGEN PRESENTATION; ARTERY DISEASE; ARTICLE; CELL MIGRATION; DRUG EFFECT; HELPER CELL; MEDIATOR RELEASE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0032761854     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65512-5     Document Type: Article

References (59)

1. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A: IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991, 147:3815-3822
2. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation by interleukin 10. J Exp Med 1991, 174:1549-1555
3. Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989, 170:2081-2095
4. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793
5. Danzer SG, Kirchner H, Rink L: Cytokine interactions in human mixed lymphocyte culture. Transplantation 1994, 57:1638-1642
6. Taga K, Tosato G: IL-10 inhibits human T cell proliferation and IL-2 production. J Immunol 1992, 148:1143-1148
7. Ding L, Shevach EM: IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J Immunol 1992, 148:3133-3139
8. de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991, 174:915-924
9. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993, 151:1224-1234
10. Chang CH, Furue M, Tamaki K: Selective regulation of ICAM-1 and major histocompatibility complex class I and II molecule expression on epidermal Langerhans cells by some of the cytokines released by keratinocytes and T cells. Eur J Immunol 1994, 24:2889-2895
11. Hall BM: Cells mediating allograft rejection. Transplantation 1991, 51:1141-1151
12. Mottram PL, Han WR, Purcell LJ, McKenzie IF, Hancock WW: Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-γ in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995, 59: 559-565
13. Bacchetta R, Bigler M, Touraine JL, Parkman R, Tovo PA, Abrams J, de Waal Malefyt R, de Vries JE, Roncarolo MG: High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J Exp Med 1994, 179:493-502
14. Qin L, Chavin KD, Ding Y, Tahara H, Favaro JP, Woodward JE, Suzuki T, Robbins PD, Lotze MT, Bromberg JS: Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol 1996, 156:2316-2323
15. Qian S, Li W, Li Y, Fu F, Lu L, Fung JJ, Thomson AW: Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice. Transplantation 1996, 62:1709-1714
16. Zheng XX, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol 1995, 154:5590-5600
17. Lee MS, Wogensen L, Shizuru J, Oldstone MB, Sarvetnick N: Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J Clin Invest 1994, 93:1332-1338
18. Li W, Fu F, Lu L, Narula SK, Fung JJ, Thomson AW, Qian S: Systemic administration of anti-interleukin-10 antibody prolongs organ allograft survival in normal and presensitized recipients. Transplantation 1998, 66:1587-1596
19. Paul LC, Fellstrom B: Chronic vascular rejection of the heart and the kidney. Have rational treatment options emerged? Transplantation 1992, 53:1169-1179
20. Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P: Human coronary transplantation-associated arteriosclerosis: evidence for a chronic immune reaction to activated graft endothelial cells. Am J Pathol 1991, 138:791-798
21. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P: Interferon-γ deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997, 100:550-557
22. Russell PS, Chase CM, Winn HJ, Colvin RB: Coronary atherosclerosis in transplanted mouse hearts. III. Effects of recipient treatment with a monoclonal antibody to interferon-gamma. Transplantation 1994, 57: 1367-1371
23. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA: Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 1993, 259:1739-1742
24. Corry RJ, Winn HJ, Russell PS: Primary vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 1973, 16:343-350
25. Russell PS, Chase CM, Winn HJ, Colvin RB: Coronary atherosclerosis in transplanted mouse hearts. I. Time course and immunogenetic and immunopathological considerations. Am J Pathol 1994, 144:260-274
26. Prussin C, Metcalfe DD: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods 1995, 188:117-128
27. O'Garra A, Murphy K: Role of cytokines in determining T cell function. Weirs Handbook of Experimental Immunology, Vol. 4. Edited by Weir DM. Blackwell Science, Cambridge, MA, 1996, pp. 226, 1-226. 10
28. Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furukawa Y, Shimizu K, Libby P, Mitchell RN: IFN-γ-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol 1998, 153 1383-1392
29. Hsu SM, Raine L, Fanger H: The use of antiavidir antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Palhol 1981, 75:816-821
30. Billingham ME, Cary NR, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group, The International Society for Heart Transplantation. J Heart Transplant 1990, 9:587-593
31. Geissler K: Current status of clinical development of interleukin-10. Curr Opin Hematol 1996, 3:203-208
32. Asano Y, Komuro T, Tada T: Synergistic T-T cell interaction present in alloreactivity: determination of "MLR helper" T cell subsets. Int Immunol 1990, 2:1203-1211
33. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN: Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts. Am J Pathol 1998, 152: 1187-1197
34. Hruban RH, Beschorner WE, Baumgartner WA, Augustine SM, Ren H, Reitz BA, Hutchins GM: Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis. Am J Pathol 1990, 137:871-882
35. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA: Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986, 137:245-254
36. Masinovsky B, Urdal D, Gallatin WM: IL-4 acts synergistically with IL-1β to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J Immunol 1990, 145:2886-2895
37. Pober JS, Gimbrone MA Jr, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA: Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol 1986, 137:1893-1896
38. Rosa F, Fellous M: The effect of gamma-interferon on MHC-antigens. Immunol Today 1984, 5:261-262
39. Skoskiewicz MJ, Colvin RB, Schneeberger EE, Russell PS: Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon. J Exp Med 1985, 162:1645-1664
40. Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, Winn KJ, Pearson TC: Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996, 381:434-438
41. Mitra RS, Judge TA, Nestle FO, Turka LA, Nickoloff BJ: Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10: differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J Immunol 1995, 154:2668-2677
42. Ozawa H, Aiba S, Nakagawa S, Tagami H: Interferon-gamma and interleukin-10 inhibit antigen presentation by Langerhans cells for T helper type 1 cells by suppressing their CD80 (B7-1) expression. Eur J Immunol 1996, 26:648-652
43. Olikowsky T, Wang ZQ, Dudhane A, Horowitz H, Conti B, Hoffmann MK: Two distinct pathways of human macrophage differentiation are mediated by interferon-gamma and interleukin-10. Immunology 1997, 91:104-108
44. Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A: The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol 1996, 8:688-693
45. + IFN-γ-producing cells. J Immunol 1997, 158:643-648
46. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK: IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection: evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol 1996, 157: 1951-1957
47. York IA, Rock KL: Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol 1996, 14:369-396
48. Carbone FR, Kurts C, Bennett SR, Miller JF, Heath WR: Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol Today 1998, 19:368-373
49. - T lymphocyte migration. J Immunol 1993, 151 4545-4551
50. Chen WF, Zlotnik A: IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 1991, 147:528-534
51. + T cells into subpopulations with distinct cytokine profiles. J Immunol 1995, 155:2928-2937
52. Li L, Sad S, Kägi D, Mosmann TR: CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions. J Immunol 1997, 158:4152-4161
53. - human blood B lymphocytes in response to stimulation with activated T cells and agonistic antibodies: effect of IL-10, IL-2 and mode of activation of T cells. Clin Exp Immunol 101:369-375
54. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J: Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992, 89:1890-1893
55. Marcelletti JF, Katz DH: IL-10 stimulates murine antigen-driven antibody responses in vitro by regulating helper cell subset participation. Cell Immunol 1996, 167:86-98
56. Qian Z, Jakobs FM, Pfaff-Amesse T, Sanfilippo F, Baldwin WM III: Complement contributes to the rejection of complete and class I major histocompatibility complex-incompatible cardiac allografts. J Heart Lung Transplant 1998, 17:470-478
57. Brandle D, Joergensen J, Zenke G, Burki K, Hof RP: Contribution of donor-specific antibodies to acute allograft rejection: evidence from B cell-deficient mice. Transplantation 1998, 65:1489-1493
58. Russell PS, Chase CM, Winn HJ, Colvin RB: Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol 1994, 152:5135-5141
59. Chow LH, Huh S, Jiang J, Zhong R, Pickering JG: Intimal thickening develops without humoral immunity in a mouse aortic allograft model of chronic vascular rejection. Circulation 1996, 94:3079-3082