Ly-6A is critical for the function of double negative regulatory T cells

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1584-1592

  Zhang, Zhu Xu ^a   Stanford, William L ^b   Zhang, Li ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

DN T cell; Ly 6A; Regulatory; Transplantation

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE PROTEIN; INTERLEUKIN 10;

ANIMAL CELL; ARTICLE; CELL KILLING; CONTROLLED STUDY; DOWN REGULATION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; SIGNAL TRANSDUCTION; SKIN ALLOGRAFT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WILD TYPE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, LY; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 0036080434     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1584::AID-IMMU1584>3.0.CO;2-2     Document Type: Article

References (43)

1. What is the role of regulatory T cells in transplantation tolerance?
2. The role of different subsets of T regulatory cells in controlling autoimmunity
3. + T cell as immune regulatory cell
4. + T cell subsets in determining transplantation rejection or tolerance
5. + regulatory T cells
6. Evidence for epitope spreading and active suppression in skin graft tolerance after donor-specific transfusion
7. Mechanisms of long-term donor-specific allograft survival induced by pre-transplant infusion of lymphocytes
8. Allograft tolerance induction in adult mice associated with functional deletion of specific CTL precursors
9. + helper T cells and prolonged survival of the corresponding class I H-2-disparate skin graft
10. Pretransplant administration of a single donor class I major histocompatibility complex molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: Evidence for linked epitope suppression
11. Levels of peripheral T cell tolerance induced by different doses of tolerogen
12. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression
13. Kinetic analysis of Ly-6 gene induction in a T lymphoma by interferons and interleukin 1, and demonstration of Ly-6 inducibility in diverse cell types
14. Ly-6: A multigene family in search of a function
15. Structural characterization of the TAP molecule: A phosphatidylinositol- linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1
16. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor
17. Selective up-regulation by interferon-gamma of surface molecules of the Ly-6 complex in resting T cells: The Ly-6A/E and TAP antigens are preferentially enhanced
18. Down-regulation of IL-2 production by activation of T cells through Ly-6A/E
19. Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway
20. Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies
21. Thy-1 and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex
22. Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity
23. Inhibition of Ly-6A antigen expression prevents T cell activation
24. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases
25. Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells
26. Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice
27. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
28. IL-10 inhibits cytokine production by activated macrophages
29. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
30. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
31. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function
32. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10
33. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival
34. Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens
35. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts
36. Systemic administration of cellular interleukin-10 can exacerbate cardiac allograft rejection in mice
37. Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8
38. The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion
39. A monoclonal antibody against the 66-kDa protein expressed in mouse spleen and thymus inhibits Ly-6A.2-dependent cell-cell adhesion
40. GPI-microdomains: A role in signaling via immunoreceptors
41. Assembly of myelin by association of proteolipid protein with cholest
42. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
43. Membrane compartmentation is required for efficient T cell activation