Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters

Biochemical Journal

Volumn 377, Issue 1, 2004, Pages 131-139

  Taylor, Kathryn M ^a   Morgan, Helen E ^a   Johnson, Andrea ^a   Nicholson, Robert I ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

HKE4; LIV 1; Metalloprotease; SLC39A7; Zinc transporter; ZIP transporter

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; GENETIC ENGINEERING; MOLECULAR STRUCTURE;

PLASMA MEMBRANES;

PROTEINS;

CARRIER PROTEIN; FLUORESCENT DYE; MEMBRANE PROTEIN; PROTEIN KE4; PROTEIN LIV 1; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SEQUENCE; ARTICLE; CELL GROWTH; CELL LEVEL; CELL MEMBRANE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; ION TRANSPORT; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; TEMPERATURE; TIME;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CHO CELLS; CRICETINAE; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; ZINC;

MAMMALIA;

EID: 1642494591     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031183     Document Type: Article

References (37)

1. Sugawara, A., Uruno, A., Nagata, T., Taketo, M. M., Takeuchi, K. and Ito, S. (1998) Characterization of mouse retinoid X receptor (RXR)-β gene promoter: negative regulation by tumor necrosis factor (TNF)-α. Endocrinology 139, 3030-3033
2. Ando, A., Kikuti, Y. Y., Shigenari, A., Kawata, H., Okamoto, N., Shiina, T., Chen, L., Ikemura, T., Abe, K., Kimura, M. et al. (1996) cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. Genomics 35, 600-602
3. Hanson, I. M. and Trowsdale, J. (1991) Colinearity of novel genes in the class II regions of the MHC in mouse and human. Immunogenetics 34, 5-11
4. Janatipour, M., Naumov, Y., Ando, A., Sugimura, K., Okamoto, N., Tsuji, K., Abe, K. and Inoko, H. (1992) Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions. Immunogenetics 35, 272-278
5. Nagata, T., Weiss, E. H., Abe, K., Kitagawa, K., Ando, A., Yara-Kikuti, Y., Seldin, M. F., Ozato, K., Inoko, H. and Taketo, M. (1995) Physical mapping of the retinoid X receptor B gene in mouse and human. Immunogenetics 41, 83-90
6. Eng, B. H., Guerinot, M. L., Eide, D. and Saier, Jr, M. H. (1998) Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J. Membr. Biol. 166, 1-7
7. Lasswell, J., Rogg, L. E., Nelson, D. C., Rongey, C. and Bartel, B. (2000) Cloning and characterization of IAR1, a gene required for auxin conjugate sensitivity in Arabidopsis. Plant Cell 12, 2395-2408
8. 2+ homeostasis. IUBMB Life 49, 249-253
9. Taylor, K. M. and Nicholson, R. I. (2003) The LZT proteins: the new LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta. Biomembranes 1611, 16-30
10. Gaither, L. A. and Eide, D. J. (2001) Eukaryotic zinc transporters and their regulation. Biometals 14, 251-270
11. Stathakis, D. G., Burton, D. Y., McIvor, W. E., Krishnakumar, S., Wright, T. R. and O'Donnell, J. M. (1999) The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Genetics 153, 361-382
12. Vallee, B. L. and Auld, D. S. (1990) Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry 29, 5647-5659
13. Vallee, B. L. and Falchuk, K. H. (1993) The biochemical basis of zinc physiology. Physiol. Rev. 73, 79-118
14. Truong-Tran, A. Q., Carter, J., Ruffin, R. E. and Zalewski, P. D. (2001) The role of zinc in caspase activation and apoptotic cell death. Biometals 14, 315-330
15. Koh, J. Y., Sun, S. W., Gwag, B. J., He, Y. Y., Hsu, C. Y. and Choi, D. W. (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016
16. Gaither, L. A. and Eide, D. J. (2000) Functional expression of the human hZIP2 zinc transporter. J. Biol. Chem. 275, 5560-5564
17. Gaither, L. A. and Eide, D. J. (2001) The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. J. Biol. Chem. 276, 22258-22261
18. Taylor, K. M., Morgan, H. E., Johnson, A., Hadley, L. J. and Nicholson, R. I. (2003) Structure-function analysis of LIV-1, the breast cancer associated protein that belongs to a new subfamily of zinc transporters. Biochem. J. 375, 51-59
19. Thompson, J. D., Higgins, D. G. and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680
20. Taylor, K. M., Trimby, A. R. and Campbell, A. K. (1997) Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerisation. Immunology 91, 20-27
21. Ma, D. and Jan, L. Y. (2002) ER transport signals and trafficking of potassium channels and receptors. Curr. Opin. Neurobibl. 12, 287-292
22. Hauri, H. P., Appenzeller, C., Kuhn, F. and Nufer, O. (2000) Lectins and traffic in the secretory pathway. FEBS Lett. 476, 32-37
23. Brendel, V., Bucher, P., Nourbakhsh, I., Blaisdell, B. E. and Karlin, S. (1992) Methods and algorithms for statistical analysis of protein sequences. Proc. Natl. Acad. Sci. U.S.A. 89, 2002-2006
24. 2+ and other metal ions. In Handbook of Fluorescent Probes and Research Products, 8th edn (Gregory, J. D. and Mallery, S., eds.), Chapter 20, Molecular Probes, Eugene, OR
25. 2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc. Natl. Acad. Sci. U.S.A. 96, 2414-2419
26. Begum, N. A., Kobayashi, M., Moriwaki, Y., Matsumoto, M., Toyoshima, K. and Seya, T. (2002) Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures. Genomics 80, 630-645
27. Di Virgilio, F., Steinberg, T. H. and Silverstein, S. C. (1990) Inhibition of Fura-2 sequestration and secretion with organic anion transport blockers. Cell Calcium 11, 57-62
28. Kendall, J. M. and Badminton, M. N. (1998) Aequorea victoria bioluminescence moves into an exciting new era. Trends Biotechnol. 16, 216-224
29. Suzuki, A. and Endo, T. (2002) Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes. Gene 284, 31-40
30. Gitan, R. S., Luo, H., Rodgers, J., Broderius, M. and Eide, D. (1998) Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. J. Biol. Chem. 273, 28617-28624
31. Petris, M. J., Mercer, J. F., Culvenor, J. G., Lockhart, P., Gleeson, P. A. and Camakaris, J. (1996) Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking. EMBO J. 15, 6084-6095
32. Manning, D. L., McClelland, R. A., Knowlden, J. M., Bryant, S., Gee, J. M., Green, C. D., Robertson, J. F., Blamey, R. W., Sutherland, R. L., Ormandy, C. J. et al. (1995) Differential expression of oestrogen regulated genes in breast cancer. Acta Oncol. 34, 641-646
33. Wang, K., Zhou, B., Kuo, Y. M., Zemansky, J. and Gitschier, J. (2002) A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am. J. Hum. Genet. 71, 66-73
34. Strausberg, R. L., Feingold, E. A., Grouse, L. H., Derge, J. G., Klausner, R. D., Collins, F. S., Wagner, L., Shenmen, C. M., Schuler, G. D., Altschul, S. F. et al. (Mammalian Gene Collection Program Team) (2002) Generation and initial analysis of more than 15000 fullshy; length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99, 16899-16903
35. Hofmann, K. and Stoffel, W. (1993) TMbase - a database of membrane spanning proteins segments. Biol. Chem. Hoppe-Seyler 347, 166-172
36. Molloy, S. S., Anderson, E. D., Jean, F. and Thomas, G. (1999) Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis. Trends Cell Biol. 9, 28-35
37. Seidah, N. G. and Chretien, M. (1999) Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848, 45-62