Immunological markers contributing to successful aging in Bulgarians

Experimental Gerontology

Volumn 39, Issue 4, 2004, Pages 637-644

  Naumova, Elissaveta ^a   Mihaylova, Anastasia ^a   Ivanova, Milena ^a   Michailova, Snejina ^a   Penkova, Kalina ^a   Baltadjieva, Daniela ^a  

^a UNIVERSITY HOSPITAL ALEXANDROVSKA   (Bulgaria)

Author keywords

Aging; Bulgarians; Cytokine gene polymorphism; HLA; Lymphocyte subsets

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INTERLEUKIN 10; INTERLEUKIN 6;

ADULT; AGED; AGING; ALLELE; AUTOIMMUNITY; BULGARIA; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC RISK; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOGENETICS; IMMUNOPHENOTYPING; INFLAMMATION; LONGEVITY; MALE; MARKER GENE; NORMAL HUMAN; PRIORITY JOURNAL; SEGREGATION ANALYSIS; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BULGARIA; CYTOKINES; FEMALE; GENE FREQUENCY; GENES, MHC CLASS I; GENES, MHC CLASS II; HAPLOTYPES; HUMANS; IMMUNOPHENOTYPING; LONGEVITY; MALE; MIDDLE AGED; PEDIGREE; POLYMORPHISM, GENETIC; T-LYMPHOCYTE SUBSETS;

EID: 1642462949     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.08.014     Document Type: Conference Paper

References (47)

1. Akisaka M., Suzuki M. Okinawa Longevity Study. Molecular genetic analysis of HLA genes in the very old. Nippon Ronen Igakkai Zasshi. 35:1998;294-298.
2. Amadori A., Zamarchi R., Desilvestro G., Forza G., Cavatton G., Danieli G.A., Clementi M., Chiecobianchi L. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat. Med. 1:1995;1279-1283.
3. Awad M.R., El-Gamel A., Simm E., Hasleton P., Yonan N., Deiraniya A.K., Sinnott P.J., Hutchinson I.V. Genotype variations in the transforming growth factor-beta 1 gene: an association with TGF-β production, fibrotic lung disease and graft fibrosis after lung transplantation. Transplantation. 66:(8):1998;1014-1020.
4. Azuma M., Cayabyab M., Philips J.H., Lanier L.L. Requirements for CD28 - dependant T cell-mediated cytotoxicity. J. Immunol. 150:(6):1993;2091-2101.
5. Bidwell J., Keen L., Gallagher G., Kimberly R., Huizinga T., McDermott M.F., Oksenberg J., McNicholl J., Pociot F., Hardt C., D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immunity. 1:1999;3-19.
6. Bidwell J., Keen L., Gallagher G., Kimberly R., Huizinga T., McDermott M.F., Oksenberg J., McNicholl J., Pociot F., Hardt C., D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immunity. 2:(Supplement 1):2001;61-70.
7. Bonafe M., Olivieri F., Cavallone L., Giovagnetti S., Mayegiani F., Cardelli M., Pieri C., Marra M., Antonicelli R., Lisa R., Rizzo M.R., Paolisso G., Monti D., Franceschi C. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur. J. Immunol. 31:2001;2357-2361.
8. Bruunsgaard H. Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8:2001;131-136.
9. Bruunsgaard H., Pedersen M., Pedersen B.K. Aging and proinflammatory cytokines. Curr Opin Hematol. 8:2001;131-136.
10. Caruso C., Candore G., Romano G., Lio D., Bonafe M., Valensin S., Franceschi C. HLA, aging, and longevity: a critical reappraisal. Hum. Immunol. 61:2000;942-949.
11. Clementi M., Forabosco P., Amadori A., Zamarchi R., De Silvestro G., Di Gianantonio E., Chieco-Bianchi L., Tenconi R. CD4 and CD8 T lymphocyte inheritance: evidence for major autosomal recessive genes. Hum. Genet. 105:1999;337-342.
12. Crawley E., Kay R., Sillibourne J., Patel P., Hutchinson I., Woo P. Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukine-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 42:1999;1101-1108.
13. Dawkins R., Leelayuwat C., Guadieri S., Tay G., Hui J., Cattley S., Martinez P., Kulski J. Genomics of the major histocompatibility complex: haplotypes, duplications, retroviruses and disease. Immunol. Rev. 167:1999;275.
14. Doria G., Frasca D. Genes, immunity, and senescence: looking for a link. Immunol. Rev. 160:1997;159-170.
15. Effros R. Costimulatory mechanisms in the elderly. Vaccine. 18:2000;1661.
16. Effros R., Boucher N., Porter V., Zhu X., Spaulding C.C., Walford R.L., Kronenberg M., Cohen D., Schachter F.F. Decline in CD28+ T cells in centenarians and in long term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29:1994;601.
17. Ershler W.B., Keller E.T. Age-associated increase of interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51:2000;245-270.
18. Fagnoni F.F., Vescovini R., Mazzola M., Bologna G., Nigro E., Lavagetto G., Franceschi C., Passeri M., Sansoni P. Expansion of cytotoxic CD8+ CD28- T cells in healthy aging people, including centenarians. Immunology. 88:(4):1996;501-507.
19. Ferguson F.G. Immune parameters in a longitudinal study in a very old population of Swedish people: a comparison between survivors and non-survivors. J. Gerontol. 50A:(6):1995;B378-B382.
20. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphires S., Woo P. Effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with System-onset juvenile chronic arthritis. J. Clin. Invest. 102:1998;1369-1376.
21. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Annu. NY Acad. Sci. 908:2000;244-254.
22. Hall M.A., Norman P.J., Thiel B., Tiwari H., Peiffer A., Vaughan R.W., Prescott S., Leppert M., Schork N.J., Lanchbury J.S. Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations. Am. J. Hum. Genet. 70:2002;1172-1182.
23. Haukim N., Bidwell J.L., Smith A.J.P., Keen L.J., Gallagher G., Kimberly R., Huizinga T., McDermott M.F., Oksenberg J., McNicholl J., Pociot F., Hardt C., D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immunity. 3:(Supplement 2):2002;313-330.
24. Haung D.R., Pirskanen R., Matell G., Lefvert A.K. Tumor necrosis factor-alpha polymorphism and secretion in myasthenia gravis. J. Neuroimmunol. 94:1999;165-171.
25. Ivanova R., Hénon N., Lepage V., Charron D., Vicaut E., Schächter F. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum. Mol. Genet. 7:1998;187-194.
26. Ivanova M., Spassova P., Michailova A., Naumova E. Distribution of HLA class I alleles and haplotypes in Bulgarians-contribution to understanding the origin of the population. Tissue Antigens. 57:2001;208-215.
27. Ivanova M., Rozemuller E., Tyufekchiev N., Michailova A., Tilanus M., Naumova E. HLA polymorphism in Bulgarians defined by high-resolution typing methods in comparison with other populations. Tissue Antigens. 60:2002;496-504.
28. Ivanova M., Michailova S., Michailova A., Nedialkova A., Naumova E. Moecular model for HLA class II associations in common autoimmune diseases. Genes Immunity. 4:2003;146.
29. Kroeger K.M., Steer J.H., Joyce D.A., Abraham L.J. Effects of stimulus and cell type on the expression of the -308 tumor necrosis factor promoter polymorphism. Cytokine. 12:2000;110-119.
30. Lagaay A.M., D'Amaro J., Ligthart G.J., Schreuder G.M., van Rood J.J., Hijmans W. Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. Annu. NY Acad. Sci. 621:1991;78.
31. Lio D., Scola L., Crivello A., Bonafe M., Franceschi C., Olivieri F., Colonna-Romano G., Candore G., Caruso C. Allele frequencies of +874T->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp. Gerontol. 37:2002;315-319.
32. Lio D., Scola L., Crivello A., Colonna-Romano G., Candore G., Bonafe M., Cavallone L., Franceschi C., Caruso C. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immunity. 3:2002;30-33.
33. Maurer M., Kruse N., Giess R., Toyka K.V., Rieckmann P. Genetic variation at position -1082 of interleukin 10 (IL10) promotor and the outcome of multiple sclerosis. J. Neuroimmunol. 104:2000;98-100.
34. Miller S.A., Dykes D., Polesky H.F. A simple sating-out procedure for extracting DNA form human nucleated cells. Nucl. Acids Res. 16:1988;1215.
35. Modica M.A., Cammarata G., Caruso C. HLA-B8, DR3 phenotype and lymphocyte responses to phytohaemagglutinin. J. Immunogenet. 17:1990;101-107.
36. Nociari M.M., Telford W., Russo C. Postthymic development of CD28-CD8+ T cell subsets: age-associated expansion and shift from memory to naive phenotype. J. Immunol. 162:1999;3327-3335.
37. Olsson J., Wikby A., Johansson B., Lofgren S., Nilsson B.-O., Ferguson F.G. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech. Ageing Dev. 121:2000;187-201.
38. Pawelec G., Adibzadeh M., Solana R., Beckman I. The T cell in the aging individual. Mech. Ageing Dev. 93:1997;35.
39. Proust J., Moulias R., Fumeron F., Bekkhoucha F., Busson M., Schmid M., Hors J. HLA and longevity. Tissue Antigens. 19:1982;168.
40. Rea I.M., Middleton D. Is the phenotyping combination A1B8Cw7DR3 a marker for male longevity? J. Am. Geriatr. Soc. 42:1994;978.
41. Shneider S., Kueffer J.M., Roessli D., Excoffier L. Arlequin: A Software Environment for the Analysis of Population Genetics Data. 1996;Genetics and Biometry Lab, Geneva.
42. Slatkin M., Excoffier L. Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm. Heredity. 76:1996;377-383.
43. Thorsby E. HLA associated diseases. Hum. Immunol. 53:1997;1.
44. Turner D.M., Grant S.C.D., Yonan N., Sheldon S., Dyer P.A., Sinnott P., Hutchinson I.V. Cytokine genotypes and heart transplant rejection. Transplantation. 64:1997;776-778.
45. Volpato S., Gyralink J.M., Ferrucci L., Balfour J., Chaves P., Fried L.P., Harris T.B. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation. 103:2001;947-953.
46. Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F.G. Changes in CD8 and CD4 lymphocyte subsets, T-cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO immune study. Mech. Aging Dev. 102:1998;187-198.
47. Wikby A., Johansson B., Olsson J., Lofgren S., Nilsson B., Ferguson F. Expansion of peripheral blood CD8 T lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp. Gerontol. 37:2002;445-453.