Tumour necrosis factor-α polymorphism and secretion in myasthenia gravis

Journal of Neuroimmunology

Volumn 94, Issue 1-2, 1999, Pages 165-171

  Huang, Deren ^a   Pirskanen, Ritva ^b   Matell, Georg ^a   Lefvert, Ann Kari ^a  

^a The Immunological Research Unit   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Disease association analysis; Gene expression; Myasthenia gravis; Tumour necrosis factor

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; FEMALE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; SWEDEN;

ADULT; AGE OF ONSET; AGED; ALLELES; ANTIGENS, CD3; FEMALE; GENE EXPRESSION; HISTOCOMPATIBILITY TESTING; HLA-B8 ANTIGEN; HLA-DR3 ANTIGEN; HUMANS; HYPERPLASIA; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; NEUROMUSCULAR JUNCTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, NICOTINIC; SWEDEN; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033081127     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00253-7     Document Type: Article

References (26)

1. Balasa B., Deng C., Lee J., Bradley L.M., Dalton D.K., Christadoss P., Sarvetnick N. Interferon γ (IFN-γ) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J. Exp. Med. 186:1997;385-391.
2. Barbara J.A., van Ostade X., Lopez A.F. Tumour necrosis factor-alpha (TNF-α): the good, the bad and potentially very effective. Immunol. Cell. Bio. 74:1996;434-443.
3. Bouma G., Crusius J.B.A., Pool M.O., Kolkman J.J., von Blomberg B.M.E., Kostense P.J., Giphart M.J., Schreuder G.M.T.H., Meuwissen S.G.M., Pena A.S. Secretion of tumour necrosis factor α and lymphotoxin α in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease. Scand. J. Immunol. 43:1996;456-463.
4. Carroll M.C., Katzman P., Alicot E.M., Koller B.H., Geraghty D.E., Orr H.T., Strominger J.L., Spies T. Linkage map of the human major histocompatibility complex including the tumour necrosis factor genes. Proc. Natl. Acad. Sci. USA. 84:1987;8535-8539.
5. Degli-Esposti M.A., Andreas A., Christansen F.T., Schalke B., Albert E., Dawkins R.L. An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes. Immunogenetics. 35:1992;355-364.
6. Demaine A., Willcox N., Janer M., Welsh K., Newson-Davis J. Immunologlobulin heavy chain gene associations in myasthenia gravis: new evidence for disease heterogeneity. J. Neurol. 239:1992;53-56.
7. Drachman D.B. Myasthenia gravis. N. Engl. J. Med. 330:1994;1797-1810.
8. Garchon H.-J., Djabiri F., Viard J.-P., Gajdos P., Bach J.-F. Involvement of human muscle acetylcholine receptor α-subunit gene (CHRNA) in susceptibility to myasthenia gravis. Proc. Natl. Acad. Sci. USA. 91:1994;4668-4672.
9. Giroir B.P., Brown T., Beutler B. Constitutive synthesis of tumour necrosis factor in the thymus. Proc. Natl. Acad. Sci. USA. 89:1992;4864-4868.
10. Gu D., Wogensen L., Calcutt N.A., Xia C., Zhu S., Merlie J.P., Fox H.S., Lindstrom J., Powell H.C., Sarvetnick N. Myasthenia gravis-like syndrome induced by expression of interferon γ in the neuromuscular junction. J. Exp. Med. 181:1995;547-557.
11. He B., Navikas V., Lundahl J., Söderström M., Hillert J. Tumor necrosis factor α -308 alleles in multiple sclerosis and optic neuritis. J. Neuroimmunol. 63:1995;143-147.
12. Heckmann J.M., Morrison K.E., Emeryk-Szajewska B., Strugalska H., Bergoffen J., Willcox N., Newsom-Davis J. Human muscle acetylcholine receptor α subunit gene (CHRNA1) association with autoimmune myasthenia gravis in black, mixed-ancestry and caucasian subjects. J. Autoimmunol. 9:1996;175-180.
13. Hjelmström P., Giscombe R., Lefvert A.K., Grunewald J., Pirskanen R., Kockum I., Landin-Olsson M., Sanjeevi C.B. Different HLA-DQ are postively and negatively associated in Swedish patients with myasthenia gravis. Autoimmunity. 22:1995;59-65.
14. Hjelmström P., Peacock C.S., Giscombe R., Pirskanen R., Lefvert A.K., Blackwell J.M., Sanjeevi C.B. Polymorphism in tumor necrosis factor genes associated with myasthenia gravis. J. Neuroimmunol. 88:1998;137-143.
15. Hohlfeld R., Wekerle H. The role of thymus in myasthenia gravis. Adv. Neuroimmunol. 4:1994;373-386.
16. Huang D., Pirskanen R., Hjelmström P., Lefvert A.K. Polymorphisms in IL-1β and IL-1 receptor antagonist genes are associated with myasthenia gravis. J. Neuroimmunol. 81:1998;76-81.
17. Lefvert A.K., Bergström K., Matell G., Osterman P.O., Pirskanen R. Determination of acetylcholine receptor antibodies in myasthenia gravis: clinical usefulness and pathogenetic implications. J. Neuro. Neurosurg. Psychiat. 41:1978;394-403.
18. Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W. Human lymphotoxin and tumour necrosis factor genes: structure, homology and chromosomal localization. Nucleic. Acids. Res. 13:1985;6361-6373.
19. Oksenberg J.R., Sherritt M., Begovich A.B., Erlich H.A., Bernard C.C., Cavalli-Sforza L.L., Steinman L. T-cell receptor Vα and Cα alleles associated with multiple sclerosis and myasthenia gravis. Proc. Natl. Acad. Sci. USA. 86:1989;988-992.
20. Olerup O., Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens. 39:1992;225-235.
21. Patrick J., Lindstrom J. Autoimmune response to acetylcholine receptor. Science. 180:1973;871-872.
22. Svejgaard A., Ryder L.P. HLA and disease association: detecting the strongest association. Tissue Antigens. 43:1994;18-27.
23. Vieira M.L., Caillat-Zucman S., Gajdoc P., Choen-Kaninsky S., Casteur A., Bach J.-F. Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis. J. Neuroimmunol. 47:1993;115-122.
24. Wilson A.G., di Giovine F.S., Blackmore A.I.F., Duff G.W. Single base polymorphism in the human tumour necrosis factor alpha (TNFα) gene detectable by NcoI restriction of PCR product. Hum. Mol. Genet. 1:1992;353-353.
25. Wilson A.G., de Vries N., Pociot F., di Giovine F.S., van der Putte L.B.A., Duff G.W. An allelic polymorphism within the human tumour necrosis factor α promoter region is strongly associated with HLA A1, B8, DR3 alleles. J. Exp. Med. 177:1993;557-560.
26. Wilson A.G., Symons J.A., Mcdowell T.L., McDevitt H.O., Duff G.W. Effects of a polymorphism in the human tumour necrosis factor α promoter on transcriptional activation. Proc. Natl. Acad. Sci. USA. 94:1997;3195-3199.