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Volumn 93, Issue 1-3, 1997, Pages 35-45

The T cell in the ageing individual

Author keywords

Ageing; CD28; Clonal exhaustion; Immunosenescence; Long term culture; T lymphocytes

Indexed keywords

AGING; CONFERENCE PAPER; HUMAN; LONGEVITY; MEMORY CELL; MORBIDITY; MORTALITY; PRIORITY JOURNAL; SENESCENCE; T LYMPHOCYTE;

EID: 0030933103     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01812-X     Document Type: Conference Paper
Times cited : (97)

References (51)
  • 1
    • 0024317522 scopus 로고
    • A prospective study of human immunodeficiency virus type I infection and the development of AIDS in subjects with hemophilia
    • J.J. Goedert, C.M. Kessler, L.M. Aledort et al., A prospective study of human immunodeficiency virus type I infection and the development of AIDS in subjects with hemophilia. N. Engl. J. Med., 321 (1989) 1141-1148.
    • (1989) N. Engl. J. Med. , vol.321 , pp. 1141-1148
    • Goedert, J.J.1    Kessler, C.M.2    Aledort, L.M.3
  • 2
    • 0026497207 scopus 로고
    • Immune senescence - Mechanisms and clinical implications
    • A. Ben-Yehuda and M.E. Weksler, Immune senescence - mechanisms and clinical implications. Cancer Invest., 10 (1992) 525-531.
    • (1992) Cancer Invest. , vol.10 , pp. 525-531
    • Ben-Yehuda, A.1    Weksler, M.E.2
  • 3
    • 0030056469 scopus 로고    scopus 로고
    • Aging and haemopoiesis: Implications for treatment with haemopoietic growth factors
    • G.S. Chatta and D.C. Dale, Aging and haemopoiesis: Implications for treatment with haemopoietic growth factors. Drug Aging, 9 (1996) 37-47.
    • (1996) Drug Aging , vol.9 , pp. 37-47
    • Chatta, G.S.1    Dale, D.C.2
  • 4
    • 0029987099 scopus 로고    scopus 로고
    • Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging
    • J.P. Buchanan, C.A. Peters, C.J. Rasmussen and G. Rothstein, Impaired expression of hematopoietic growth factors: A candidate mechanism for the hematopoietic defect of aging. Exp. Gerontol., 31 (1996) 135-144.
    • (1996) Exp. Gerontol. , vol.31 , pp. 135-144
    • Buchanan, J.P.1    Peters, C.A.2    Rasmussen, C.J.3    Rothstein, G.4
  • 5
    • 0029035273 scopus 로고
    • Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects
    • H. Nilsson-Ehle, B. Swolin and J. Westin, Bone marrow progenitor cell growth and karyotype changes in healthy 88-year-old subjects. Eur. J. Haematol., 55 (1995) 14-18.
    • (1995) Eur. J. Haematol. , vol.55 , pp. 14-18
    • Nilsson-Ehle, H.1    Swolin, B.2    Westin, J.3
  • 6
    • 0030003737 scopus 로고    scopus 로고
    • The hematopoietic stem cell in elderly patients with leukemia
    • A. Keating, The hematopoietic stem cell in elderly patients with leukemia. Leukemia, 10 (1996) 530-532.
    • (1996) Leukemia , vol.10 , pp. 530-532
    • Keating, A.1
  • 7
    • 0029965412 scopus 로고    scopus 로고
    • The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their adult bone marrow counterparts
    • V.I. Rebel, C.L. Miller, C.J. Eaves and P.M. Lansdorp, The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their adult bone marrow counterparts. Blood, 87 (1996) 3500-3507.
    • (1996) Blood , vol.87 , pp. 3500-3507
    • Rebel, V.I.1    Miller, C.L.2    Eaves, C.J.3    Lansdorp, P.M.4
  • 9
    • 0029940570 scopus 로고    scopus 로고
    • Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow
    • C.P. Chiu, W. Dragowska, N.W. Kim et al., Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells, 14 (1996) 239-248.
    • (1996) Stem Cells , vol.14 , pp. 239-248
    • Chiu, C.P.1    Dragowska, W.2    Kim, N.W.3
  • 10
    • 0023154993 scopus 로고
    • Hematologic data of healthy very old people
    • N.P. Zauber and A.G. Zauber, Hematologic data of healthy very old people. J. Am. Med. Assoc., 257 (1987) 2181-2184.
    • (1987) J. Am. Med. Assoc. , vol.257 , pp. 2181-2184
    • Zauber, N.P.1    Zauber, A.G.2
  • 11
    • 0027968305 scopus 로고
    • On a causal mechanism of chronic thymic involution in man
    • M. Hartwig and G. Steinmann, On a causal mechanism of chronic thymic involution in man. Mech. Ageing Dev., 75 (1994) 151-156.
    • (1994) Mech. Ageing Dev. , vol.75 , pp. 151-156
    • Hartwig, M.1    Steinmann, G.2
  • 12
    • 0029895686 scopus 로고    scopus 로고
    • Thymic involution with ageing: Obsolescence or good housekeeping?
    • A.J.T. George and M.A. Ritter, Thymic involution with ageing: Obsolescence or good housekeeping? Immunol. Today, 17 (1996) 267-272.
    • (1996) Immunol. Today , vol.17 , pp. 267-272
    • George, A.J.T.1    Ritter, M.A.2
  • 13
  • 15
    • 0024795642 scopus 로고
    • Effects of H-2 haplotype and gender on the lifespan of A and CS7BL/6 mice and their F1 and F2, and backcross offspring
    • T.E. Meyer, M.J. Armstrong and C.M. Warner, Effects of H-2 haplotype and gender on the lifespan of A and CS7BL/6 mice and their F1 and F2, and backcross offspring. Growth Dev. Aging, 53 (1989) 175-183.
    • (1989) Growth Dev. Aging , vol.53 , pp. 175-183
    • Meyer, T.E.1    Armstrong, M.J.2    Warner, C.M.3
  • 17
    • 0027968045 scopus 로고
    • Age-sensitive T cell phenotypes covary in genetically heterogeneous mice and predict early death from lymphoma
    • R.A. Miller, P. Turke, C. Chrisp et al., Age-sensitive T cell phenotypes covary in genetically heterogeneous mice and predict early death from lymphoma. J. Gerontol., 49 (1994) B255-B262.
    • (1994) J. Gerontol. , vol.49
    • Miller, R.A.1    Turke, P.2    Chrisp, C.3
  • 18
    • 0029071635 scopus 로고
    • Life-span, T-cell responses, and incidence of lymphomas in congenic mice
    • M. Salazar, T. Leong, N. Tu et al., Life-span, T-cell responses, and incidence of lymphomas in congenic mice. Proc. Natl. Acad. Sci. USA, 92 (1995) 3992-3996.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3992-3996
    • Salazar, M.1    Leong, T.2    Tu, N.3
  • 19
    • 0024429960 scopus 로고
    • Frequencies of HLA-DP alleles in the four major types of leukaemia
    • G. Pawelec, A. Rehbein, K. Schaudt and F.W. Busch, Frequencies of HLA-DP alleles in the four major types of leukaemia. Tissue Antigens, 34 (1989) 138-140.
    • (1989) Tissue Antigens , vol.34 , pp. 138-140
    • Pawelec, G.1    Rehbein, A.2    Schaudt, K.3    Busch, F.W.4
  • 20
    • 0025815434 scopus 로고
    • High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3
    • R. Wank and C. Thomssen, High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3. Nature, 352 (1991) 723-725.
    • (1991) Nature , vol.352 , pp. 723-725
    • Wank, R.1    Thomssen, C.2
  • 21
    • 0028819701 scopus 로고
    • HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: Study of 205 Italian subjects
    • G. Ricci, C. Colombo, B. Ghiazza, C. Porta, M. Moroni and M.T. Illeni, HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma: Study of 205 Italian subjects. Cancer Lett., 98 (1995) 121-125.
    • (1995) Cancer Lett. , vol.98 , pp. 121-125
    • Ricci, G.1    Colombo, C.2    Ghiazza, B.3    Porta, C.4    Moroni, M.5    Illeni, M.T.6
  • 22
    • 0028934110 scopus 로고
    • T-cell activation in HLA-B8, DR3-positive individuals - Early antigen expression defect in vitro
    • G. Candore, D. Cigna, M. Todaro et al., T-cell activation in HLA-B8, DR3-positive individuals - early antigen expression defect in vitro. Hum. Immunol., 42 (1995) 289-294.
    • (1995) Hum. Immunol. , vol.42 , pp. 289-294
    • Candore, G.1    Cigna, D.2    Todaro, M.3
  • 23
    • 0027967248 scopus 로고
    • Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity?
    • I.M. Rea and D. Middleton, Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity? J. Am. Geriatr. Soc., 42 (1994) 978-983.
    • (1994) J. Am. Geriatr. Soc. , vol.42 , pp. 978-983
    • Rea, I.M.1    Middleton, D.2
  • 24
    • 9044243014 scopus 로고    scopus 로고
    • Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia
    • M.T. Dorak, H.K.G. Machulla, M. Hentschel, K.I. Mills, J. Langner and A.K. Burnett, Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia. Int. J. Cancer, 65 (1996) 134-139.
    • (1996) Int. J. Cancer , vol.65 , pp. 134-139
    • Dorak, M.T.1    Machulla, H.K.G.2    Hentschel, M.3    Mills, K.I.4    Langner, J.5    Burnett, A.K.6
  • 25
    • 0024325071 scopus 로고
    • The cellular and subcellular bases of immunosenescence
    • M.L. Thoman and W.O. Weigle, The cellular and subcellular bases of immunosenescence. Adv. Immunol., 46 (1989) 221-262.
    • (1989) Adv. Immunol. , vol.46 , pp. 221-262
    • Thoman, M.L.1    Weigle, W.O.2
  • 27
    • 0027531321 scopus 로고
    • Transient normalization of lymphocyte blastogenic and specific antibody responses following boosting of healthy elderly subjects with tetanus toxoid
    • K.B. Armitage, E.G. Duffy, M.A. Mincek et al., Transient normalization of lymphocyte blastogenic and specific antibody responses following boosting of healthy elderly subjects with tetanus toxoid. J. Gerontol., 48 (1993) M19-M25.
    • (1993) J. Gerontol. , vol.48
    • Armitage, K.B.1    Duffy, E.G.2    Mincek, M.A.3
  • 29
    • 0001809644 scopus 로고
    • Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly
    • D.M. Murasko, P. Weiner and D. Kaye, Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly. Aging: Immunol Infectious Dis., 1 (1988) 1-23.
    • (1988) Aging: Immunol Infectious Dis. , vol.1 , pp. 1-23
    • Murasko, D.M.1    Weiner, P.2    Kaye, D.3
  • 30
    • 0025213974 scopus 로고
    • Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
    • S.J. Wayne, R.L. Rhyne, P.J. Garry and J.S. Goodwin, Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol., 45 (1990) 45-48.
    • (1990) J. Gerontol. , vol.45 , pp. 45-48
    • Wayne, S.J.1    Rhyne, R.L.2    Garry, P.J.3    Goodwin, J.S.4
  • 31
    • 0028839467 scopus 로고
    • Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
    • F.G. Ferguson, A. Wikby, P. Maxson, J. Olsson and B. Johansson, Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors. J. Gerontol. Ser. A-Biol. Sci. Med., 50 (1995) B378-B382.
    • (1995) J. Gerontol. Ser. A-Biol. Sci. Med. , vol.50
    • Ferguson, F.G.1    Wikby, A.2    Maxson, P.3    Olsson, J.4    Johansson, B.5
  • 32
    • 0028891555 scopus 로고
    • The immunology of exceptional individuals: The lesson of centenarians
    • C. Franceschi, D. Monti, P. Sansoni and A. Cossatizza, The immunology of exceptional individuals: the lesson of centenarians. Immunol. Today, 16 (1995) 12-16.
    • (1995) Immunol. Today , vol.16 , pp. 12-16
    • Franceschi, C.1    Monti, D.2    Sansoni, P.3    Cossatizza, A.4
  • 33
    • 0028088390 scopus 로고
    • An investigation of mutation as a function of age in humans
    • C.M. King, E.S. Gillespie, P.G. McKenna and Y.A. Barnett, An investigation of mutation as a function of age in humans. Mutat. Res., 316 (1994) 79-90.
    • (1994) Mutat. Res. , vol.316 , pp. 79-90
    • King, C.M.1    Gillespie, E.S.2    McKenna, P.G.3    Barnett, Y.A.4
  • 36
    • 0028218806 scopus 로고
    • Extrathymic development and function of human T-lymphocytes from bone marrow cells in vitro
    • M. Adibzadeh, H.J. Bühring, T. Daikeler, et al., Extrathymic development and function of human T-lymphocytes from bone marrow cells in vitro. Cell Immunol., 154 (1994) 25-42.
    • (1994) Cell Immunol. , vol.154 , pp. 25-42
    • Adibzadeh, M.1    Bühring, H.J.2    Daikeler, T.3
  • 37
    • 0028806679 scopus 로고
    • Long-term culture of monoclonal human T lymphocytes: Models for immunosenescence?
    • M. Adibzadeh, H. Pohla, A. Rehbein and G. Pawelec, Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech. Ageing Dev., 83 (1995) 171-183.
    • (1995) Mech. Ageing Dev. , vol.83 , pp. 171-183
    • Adibzadeh, M.1    Pohla, H.2    Rehbein, A.3    Pawelec, G.4
  • 39
    • 0022631917 scopus 로고
    • Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative 'helper' T cell clones
    • G. Pawelec, E.M. Schneider and P. Wernet, Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative 'helper' T cell clones. J. Immunol., 136 (1986) 402-411.
    • (1986) J. Immunol. , vol.136 , pp. 402-411
    • Pawelec, G.1    Schneider, E.M.2    Wernet, P.3
  • 41
    • 0023680577 scopus 로고
    • 'Tolerisation' of human T-helper cell clones by chronic exposure to alloantigen: Culture conditions dictate autocrine proliferative status but not acquisition of cytotoxic potential and suppressor-induction capacity
    • G. Pawelec, T. Brocker, F.W. Busch, et al., 'Tolerisation' of human T-helper cell clones by chronic exposure to alloantigen: culture conditions dictate autocrine proliferative status but not acquisition of cytotoxic potential and suppressor-induction capacity. J. Mol. Cell Immunol., 4 (1988) 21-34.
    • (1988) J. Mol. Cell Immunol. , vol.4 , pp. 21-34
    • Pawelec, G.1    Brocker, T.2    Busch, F.W.3
  • 42
    • 0028850465 scopus 로고
    • Human naive and memory T lymphocytes differ in telomeric length and replicative potential
    • N.P. Weng, B.L. Levine, C.H. June and R.J. Hodes, Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA, 92 (1995) 11091-11094.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11091-11094
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 43
    • 0028043586 scopus 로고
    • Decline in CD28 T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence
    • R.B. Effros, N. Boucher, V. Porter et al., Decline in CD28 T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol., 29 (1994) 601-609.
    • (1994) Exp. Gerontol. , vol.29 , pp. 601-609
    • Effros, R.B.1    Boucher, N.2    Porter, V.3
  • 44
    • 0029877250 scopus 로고    scopus 로고
    • Insights on immunological aging derived from the T lymphocyte cellular senescence model
    • R.B. Effros, Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp. Gerontol., 31 (1996) 21-27.
    • (1996) Exp. Gerontol. , vol.31 , pp. 21-27
    • Effros, R.B.1
  • 45
    • 8944258925 scopus 로고    scopus 로고
    • + cell sub set in HIV disease implicate replicative senescence in HIV pathogenesis
    • + cell sub set in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS, 10 (1996) F17-F22.
    • (1996) AIDS , vol.10
    • Effros, R.B.1    Allsopp, R.2    Chiu, C.P.3
  • 46
    • 0029973490 scopus 로고    scopus 로고
    • Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers
    • R. Kammerer, A. Iten, P.C. Frei and P. Burgisser, Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers. Med. Microbiol. Immunol., 185 (1996) 19-25.
    • (1996) Med. Microbiol. Immunol. , vol.185 , pp. 19-25
    • Kammerer, R.1    Iten, A.2    Frei, P.C.3    Burgisser, P.4
  • 47
    • 0027976958 scopus 로고
    • Clonal populations of T cells in normal elderly humans - The T cell equivalent to benign monoclonal gammopathy
    • D.N. Posnett, R. Sinha, S. Kabak and C. Russo, Clonal populations of T cells in normal elderly humans - the T cell equivalent to benign monoclonal gammopathy. J. Exp. Med., 179 (1994) 609-618.
    • (1994) J. Exp. Med. , vol.179 , pp. 609-618
    • Posnett, D.N.1    Sinha, R.2    Kabak, S.3    Russo, C.4
  • 48
    • 0030026329 scopus 로고    scopus 로고
    • Chagasic patients lack CD28 expression on many of their circulating T lymphocytes
    • W.O. Dutra, O.A. Martins, J.R. Cancado et al., Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand. J. Immunol., 43 (1996) 88-93.
    • (1996) Scand. J. Immunol. , vol.43 , pp. 88-93
    • Dutra, W.O.1    Martins, O.A.2    Cancado, J.R.3
  • 49
    • 0029942655 scopus 로고    scopus 로고
    • Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia
    • E. Rossi, E. Matutes, R. Morilla, K. Owusu-Ankomah, A.M. Heffernan and D. Catovsky, Zeta chain and CD28 are poorly expressed on T lymphocytes from chronic lymphocytic leukemia. Leukemia, 10 (1996) 494-497.
    • (1996) Leukemia , vol.10 , pp. 494-497
    • Rossi, E.1    Matutes, E.2    Morilla, R.3    Owusu-Ankomah, K.4    Heffernan, A.M.5    Catovsky, D.6
  • 50
    • 0029958821 scopus 로고    scopus 로고
    • - T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity
    • - T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J. Clin. Invest., 97 (1996) 2027-2037.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2027-2037
    • Schmidt, D.1    Goronzy, J.J.2    Weyand, C.M.3


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