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Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: Results from the AASK trial
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Wright JT Jr, Bakris G, Greene T, et al., and the African American Study of Kidney Disease and Hypertension Study Group. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 2002; 288:2421-2431. A major clinical trial addressing the issue of nephrosclerosis in African-Americans and how the condition is to be best treated.
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JAMA
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Wright Jr., J.T.1
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Mild renal insufficiency is associated with angiographic coronary artery disease in women
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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
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National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee
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Chobanian AV, Bakris GL, Black HR, et al. National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289:2560-2572. An exercise in punditry that belongs in everybody's collection!
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JAMA
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Chobanian, A.V.1
Bakris, G.L.2
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Progression of chronic kidney disease: The role of blood pressure control, proteinuria, and angiotensin converting enzyme inhibition
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Jafar TH, Stark PC, Schmid CH, et al., for the AIPRD study group. Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin converting enzyme inhibition. Ann Intern Med 2003; 139:244-252. A large meta-analysis that addresses highly important questions, namely the degree of blood pressure reduction and the impact of proteinuria in chronic renal disease patients without diabetes mellitus.
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Ann Intern Med
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Jafar, T.H.1
Stark, P.C.2
Schmid, C.H.3
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Guiding lights for antihypertensive treatment in patients with nondiabetic renal disease: Proteinuria and blood pressure levels?
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Mulrow CD, Townsend RR. Guiding lights for antihypertensive treatment in patients with nondiabetic renal disease: proteinuria and blood pressure levels? Ann Intern Med 2003; 139:296-299. A thoughtful editorial and commentary on the problems we face in hypertensive patients with decreased renal function.
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Ann Intern Med
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Mulrow, C.D.1
Townsend, R.R.2
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Secondary prevention of renal and cardiovascular disease: Results of a renal and cardiovascular treatment program in an Australian aboriginal community
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Hoy WE, Wang Z, Baker PRA, Kelly AM. Secondary prevention of renal and cardiovascular disease: results of a renal and cardiovascular treatment program in an Australian aboriginal community. J Am Soc Nephrol 2003; 14:S178-S185.
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Hoy, W.E.1
Wang, Z.2
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0037704567
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Baa, Baa, black sheep, are your kidneys full?
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Luft FC. Baa, Baa, black sheep, are your kidneys full? J Physiol 2003; 549:665.
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J Physiol
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Luft, F.C.1
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Congenital oligonephropathy: An inborn cause of adult hypertension and progressive renal injury?
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Brenner BM, Chertow GM. Congenital oligonephropathy: an inborn cause of adult hypertension and progressive renal injury? Curr Opin Nephrol Hypertens. 1993 Sep;2(5):691-695. Review.
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Curr Opin Nephrol Hypertens
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Brenner, B.M.1
Chertow, G.M.2
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Fetal nutrition and cardiovascular disease in adult life
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Barker DJ, Gluckman PD, Godfrey KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993 Apr 10;341(8850):938-41.
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Barker, D.J.1
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Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment
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Wintour EM, Moritz KM, Johnson K, et al. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol 2003; 549:929-935. An interesting study addressing the issue of nephron number and subsequent blood pressure values.
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J Physiol
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Wintour, E.M.1
Moritz, K.M.2
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Nephron number in patients with primary hypertension
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Keller G, Zimmer G, Mall G, et al. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348:101-108. Possibly a landmark study on the issue of nephron number and the development of hypertension in humans.
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N Engl J Med
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Keller, G.1
Zimmer, G.2
Mall, G.3
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Moritz KM, Johnson K, Douglas-Denton R, et al. Maternal glucocorticoid treatment programs alterations in the rennin-angiotensin system of the ovine fetal kidney. Endocrinology 2002; 143:445-4463.
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Moritz, K.M.1
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A stereological study of glomerular number and volume: Preliminary findings in a multiracial study of kidneys at autopsy
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Hoy WE, Douglas-Denton RN, Hughson MD, et al. A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 2003; 83:S31-S37. This paper is an important source for data on human glomerular number and size.
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Kidney Int Suppl
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Hoy, W.E.1
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Marcantoni C, Ma LJ, Federspiel C, Fogo AB. Hypertensive nephrosclerosis in African Americans versus Caucasians. Kidney Int 2002; 62:172-180. The paper is an important source of information and should be compared with the findings of Hoy et al. [16•].
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Kidney Int
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Marcantoni, C.1
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Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies
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Schmid H, Cohen CD, Henger A, et al. Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies. Kidney Int 2003; 64:356-360.
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Kidney Int
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Schmid, H.1
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Henger, A.3
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Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
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Johnson RJ, Kang DH, Feig D, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 2003; 41:1183-1190. This paper is a comprehensive review of a potentially very important issue.
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Hypertension
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Johnson, R.J.1
Kang, D.H.2
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Müller DN, Shagdarsuren E, Dechend R, et al. Immunosuppressive, anti-inflammatory treatment ameliorates angiotensin II-induced renal damage. Am J Pathol 2002; 161:1679-1693.
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Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension
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Lond
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Tostes RC, Touyz RM, He G, et al. Contribution of endothelin-1 to renal activator protein-1 activation and macrophage infiltration in aldosterone-induced hypertension. Clin Sci (Lond) 2002; 103 (Suppl. 48):25S-30S.
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The Inter-relationship between TGF-{beta}1 and nitric oxide is altered in salt-sensitive hypertension
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Ying WZ, Sanders PW. The Inter-relationship between TGF-{beta}1 and nitric oxide is altered in salt-sensitive hypertension. Am J Physiol Renal Physiol 2003; 285(5):F902-8. Epub AQ9 (added)
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Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
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Lan HY, Mu W, Tomita N, et al. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 2003; 14:1535-1548. There are several novel aspects in this report. The idea of capitalizing on Smad7, the TGF-β inhibitory Smad is an interesting idea. The delivery system would certainly have applicability in man.
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J Am Soc Nephrol
, vol.14
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Lan, H.Y.1
Mu, W.2
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Finckenberg P, Inkinen K, Ahonen J, et al. Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways. Am J Pathol 2003; 163:355-366.
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0037195056
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Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction
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2 production on the development of nephrosclerosis might not have been predicted, although an increase in blood pressure comes as less of a surprise.
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Circulation
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Yokoyama, C.1
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Sanders PW, Wang PX. Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats. BMC Nephrol 2002; 3:1.
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Titze J, Krause H, Hecht H, et al. Reduced osmotically inactive Na storage capacity and hypertension in the Dahl model. Am J Physiol Renal Physiol 2002; 283:F134-F141. This study expresses novel ideas in terms of chronic salt balance.
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Am J Physiol Renal Physiol
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Titze J, Lang R, Ilies C, et al. Osmotically inactive skin Na+ storage in rats. Am J Physiol Renal Physiol 2003 Dec;285(6):F1108-F1117. In this study perhaps the non-osmotic sodium chloride storage bin has been identified.
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Am J Physiol Renal Physiol
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Titze, J.1
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