Physical mapping of a glutamate receptor gene in relation to a balanced translocation associated with schizophrenia in a large Scottish family

Psychiatric Genetics

Volumn 7, Issue 4, 1997, Pages 165-169

  Devon, R S ^a   Porteous, D J ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Glutamate; Physical mapping; Receptor; Schizophrenia; Translocation

Indexed keywords

GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; CHROMOSOME 11Q; FAMILY STUDY; GENE MAPPING; GENE TRANSLOCATION; GENETIC MARKER; HUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; UNITED KINGDOM;

EID: 0031460551     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199724000-00005     Document Type: Article

References (22)

1. Altschul SF and Gish W (1990) Basic local alignment search tool. J Mol Biol, 215, 403-410.
2. Crouau-Roy B, Service S, Slatkin M and Freimer N (1996) A fine-scale comparison of the human and chimpanzee genomes: linkage, linkage disequilibrium and sequence analysis. Hum Mol Genet, 5, 1131-1137.
3. Don RH, Cox PT, Wainwright BJ, Baker K and Mattick JS (1991) 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucl Acids Res, 19, 4008.
4. Devon RS, Evans KL, Maule JC, Christie S, Anderson S, Brown J, Shibasaki Y, Porteous DJ and Brookes AJ (1997) Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia. Am J Med Genet (Neuropsychiatric Genet), 74, 82-90.
5. Escamilla MA, Spesny M, Reus VI, Gallegos A, Meza L, Molina J, Sandkuijl LA, Fournier E, Leon PE, Smith LB and Freimer NB (1996) Use of linkage disequilibrium approaches to map genes for bipolar disorder in the Costa Rican population. Am J Med Genet (Neuropsychiatric Genet), 67, 244-253.
6. Evans KL, Brown J, Shibasaki Y, Devon RS, He L, Arveiler B, Christie S, Maule JC, Baillie D, Slorach EM et al. (1995) A contiguous clone map over 3Mb on the long arm of chromosome 11 across a balanced translocation associated with schizophrenia. Genomics, 28, 420-428.
7. Fantes J, Redeker B, Breen M, Boyle S, Brown J, Fletcher J, Jones S, Bickmore W, Fukushima Y, Mannens M et al. (1995) Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype. Hum Mol Genet, 4, 415-422.
8. Feinberg AP and Vogelstein A (1984) A technique for radio-labelling DNA fragments to high specific activity. Anal Biochem, 137, 266-267.
9. Henglein B, Synovzik H, Groitl P, Bornkamm GW, Hartl P and Lipp M (1989) Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc. Mol Cell Biol, 9, 2105-2113.
10. Joos S, Falk MH, Lichter P, Haluska FG, Henglein B, Lenoir GM and Bornkamm GW (1992) Variable breakpoints in Burkitt lymphoma cells with chromosomal t(8;14) translocation separate c-myc and the IgH locus up to several hundred kb. Hum Mol Genet, 8, 625-632.
11. Lennon GG, Auffray C, Polymeropoulos M and Soares MB (1996) The IMAGE Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33, 151-152.
12. Miller S, Kesslak JP, Romano C and Cotman CW (1995) Roles of metabotropic glutamate receptors in brain plasticity and pathology. Ann NY Acad Sci, 757, 460-474.
13. Moore RY (1993) Principles of synaptic transmission. Ann NY Acad Sci, 695, 1-9.
14. Pearson WR and Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci USA, 85, 2444-2448.
15. Riedel G (1996) Function of metabotropic glutamate receptors in learning and memory. Trends Neurosci, 19, 219-224.
16. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning. A Laboratory Manual. CSH Laboratory Press, Cold Spring Harbor.
17. Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tome P, Aggarwal A, Bajorek E et al. (1996) A gene map of the human genome. Science, 274, 540-546.
18. St Clair D, Blackwood D, Muir W, Carothers A, Walker M, Spowart G, Gosden C and Evans HJ (1990) Association within a family of a balanced autosomal translocation with major mental illness. Lancet, 336, 13-16.
19. Taylor GR (1991) Polymerase chain reaction: basic principles and automation. In: PCR. A Practical Approach (Eds MJ McPherson, P Quirke and GR Taylor), pp. 1-14. Oxford University Press, Oxford.
20. Toru M, Kurumaji A and Ishimaru M (1994) Excitatory amino acids: implications for psychiatric disorders research. Life Sci, 55, 1683-1699.
21. Townes TM and Behringer RR (1990) Human globin locus activation region (LAR): role in temporal control. Trends Genet, 6, 219-223.
22. Wirth J, Wagner T, Meyer J, Pfeiffer RA, Tietze H, Schempp W and Scherer G (1996) Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. Hum Genet, 97, 186-193.