DNA hypomethylating agents 5-aza-2′-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNA

European Journal of Pharmacology

Volumn 445, Issue 1-2, 2002, Pages 149-150

  Manev, Hari ^a   Uz, Tolga ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cerebellar granule neuron; DNA methylation; Histone deacetylase

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTICONVULSIVE AGENT; ARACHIDONATE 5 LIPOXYGENASE; DNA; MESSENGER RNA; VALPROIC ACID;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GENE EXPRESSION REGULATION; GRANULE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; AZACITIDINE; CELLS, CULTURED; CEREBELLUM; DNA METHYLATION; NEURONS; RATS; RNA, MESSENGER; VALPROIC ACID;

EID: 0037036183     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01711-9     Document Type: Article

References (8)

1. Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation
2. Putative role of neuronal 5-lipoxygenase in an aging brain
3. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
4. Trichostatin A causes selective loss of DNA methylation in Neurospora
5. Towards a pharmacology of DNA methylation
6. Methylated cytosine and the brain: A new base for neuroscience
7. The 5-lipoxygenase promoter is regulated by DNA methylation
8. 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro