Kainate down-regulates a subset of GABAA receptor subunits expressed in cultured mouse cerebellar granule cells

Cerebellum

Volumn 3, Issue 1, 2004, Pages 27-38

  Martikainen, Ikka K ^a   Lauk, Kadri ^a   Möykkynen, Tommi ^b   Holopainen, Irma E ^a   Korpi, Esa R ^b   Uusi Oukari, Mikko ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cerebellar granule cells; GABAA receptors glutamate kainate quantitative RT PCR; Receptor down regulation

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6,7 DINITRO 2,3 QUINOXALINEDIONE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID; MESSENGER RNA; POTASSIUM ION; RECEPTOR SUBUNIT; TRITIUM; ZOLPIDEM;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CEREBELLUM; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; GENE EXPRESSION; GRANULE CELL; KNOCKOUT MOUSE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; KAINIC ACID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, GABA-A; RECEPTORS, KAINIC ACID;

EID: 1642302196     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220310020876     Document Type: Article

References (78)

1. A receptor diversity. Neuropharmacology 1996; 35: 1139-1160.
2. A receptor subtypes. Pharmacol Rev 1995; 47: 181-234.
3. A receptors. Prog Neurobiol 2002; 67: 113-159.
4. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 1992; 12: 1063-1076.
5. A receptors containing alpha6 subunits. J Neurosci 1998; 18: 2449-2457.
6. A receptors from rat brain. Eur J Pharmacol 1995; 290: 175-181.
7. A receptor α6 subunit alters benzodiazepine affinity but not allosteric GABA effects. Eur J Pharmacol 1993; 247: 23-27.
8. A receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice. Eur J Neurosci 1999; 11: 233-240.
9. Levi G, Aloisi F, Ciotti MT, Gallo V. Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures. Brain Res 1984; 290: 77-86.
10. A receptor subunit expression in the cerebellum. Eur J Pharmacol 1998; 352: 1-14.
11. A-receptor subunits result in structurally and functionally altered receptor assemblies following excitatory afferent synaptic transmission. Perspect Dev Neurobiol 1998; 5: 193-205.
12. A receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 1992; 12: 4151-4172.
13. Zheng TM, Zhu WJ, Puia G, Vicini S, Grayson DR, Costa E, et al. Changes in gamma-aminobutyrate type A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro. Proc Natl Acad Sci USA 1994; 91: 10952-10956.
14. A receptor subunit mRNA occurs only after cerebellar granule cell migration. Dev Brain Res 1993; 75: 91-103.
15. A receptor subunit mRNAs in rat cerebellar granule neurons: importance of environmental cues. J Neurochem 1996; 66: 1347-1353.
16. Gallo V, Kingsbury A, Balazs R, Jorgensen OS. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987; 7: 2203-2213.
17. Balazs R, Gallo V, Kingsbury A. Effect of depolarization on the maturation of cerebellar granule cells in culture. Brain Res 1988; 468: 269-276.
18. A receptor subunit expression by activation of N-methyl-D-aspartate-selective glutamate receptors. Mol Pharmacol 1991; 39: 599-603.
19. Harris BT, Charlton ME, Costa E, Grayson DR. Quantitative changes in alpha 1 and alpha 5 gamma-aminobutyric acid type A receptor subunit mRNAs and proteins after a single treatment of cerebellar granule neurons with N-methyl-D-aspartate. Mol Pharmacol 1994; 45: 637-648.
20. A receptor delta subunit is selectively modulated by depolarization in cultured rat cerebellar granule neurons. J Neurosci 1997; 17: 2391-2399.
21. A receptor delta subunit mRNA expression in cultured rat cerebellar granule neurons. J Neurochem 1998; 70: 1907-1915.
22. Hack NJ, Sluiter AA, Balazs R. AMPA receptors in cerebellar granule cells during development in culture. Dev Brain Res 1995; 87: 55-61.
23. Pemberton KE, Belcher SM, Ripellino JA, Howe JR. High-affinity kainate-type ion channels in rat cerebellar granule cells. J Physiol 1998; 510: 401-420.
24. Sattler R, Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 2001; 24: 107-129.
25. Ben-Ari Y, Cossart R. Kainate a double agent that generates seizures: two decades of progress. Trends Neurosci 2000; 23: 580-587.
26. A receptor subunits in the hippocampus of the rat after kainic acid-induced seizures. Epilepsy Res 1998; 32: 129-139.
27. Herndon RM, Coyle JT. Selective destruction of purkinje cells, basket-stellate cells, and golgi type II cells of the cerebellum by kainic acid: further evidence that glutamate is the granule cell transmitter. Trans Am Neurol Assoc 1977; 102: 93-96.
28. Garthwaite J, Wilkin GP. Kainic acid receptors and neurotoxicity in adult and immature rat cerebellar slices. Neuroscience 1982; 7: 2499-2514.
29. Drejer J, Schousboe A. Selection of a pure cerebellar granule cell culture by kainate treatment. Neurochem Res 1989; 14: 751-754.
30. Balazs R, Hack N, Jorgensen OS. Interactive effects involving different classes of excitatory amino acid receptors and the survival of cerebellar granule cells in culture. Int J Dev Neurosci 1990; 8: 347-359.
31. +- and kainate-mediated depolarization on survival and functional maturation of GABAergic and glutamatergic neurons in cultures of dissociated mouse cerebellum. Neurochem Res 1996; 21: 267-275.
32. Meier E, Drejer J, Schousboe A. GABA induces functionally active low-affinity GABA receptors on cultured cerebellar granule cells. J Neurochem 1984; 43: 1737-1744.
33. Messer A. The maintenance and identification of mouse cerebellar granule cells in monolayer culture. Brain Res 1977; 130: 1-12.
34. Holopainen I, Malminen O, Kontro P. Sodium-dependent high-affinity uptake of taurine in cultured cerebellar granule cells and astrocytes. J Neurosci Res 1987; 18: 479-483.
35. 3H]Ro 15-4513 binding in intact cultured cerebellar granule cells. Eur J Pharmacol 1989; 169: 53-60.
36. A receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci 1997; 17: 1350-1362.
37. A receptor subunit mRNAs by non-radioisotopic competitive RT-PCR utilizing plate-based EIA methodology. J Neurosci Methods 2000; 95: 65-73.
38. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
39. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
40. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986; 89: 271-277.
41. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
42. A receptor alpha 6 subunit gene. J Neurosci 1998; 18: 2822-2833.
43. Mogensen HS, Hack N, Balazs R, Jorgensen OS. The survival of cultured mouse cerebellar granule cells is not dependent on elevated potassium-ion concentration. Int J Dev Neurosci 1994; 12: 451-460.
44. Engblom AC, Johansen FF, Kristiansen U. Actions and interactions of extracellular potassium and kainate on expression of 13 gamma-aminobutyric acid type A receptor subunits in cultured mouse cerebellar granule neurons. J Biol Chem 2003; 278: 16543-16550.
45. A receptor expression in cultured mouse cerebellar granule cells. Neuropharmacology 2002; 43: 715-725.
46. A receptor subunit mRNAs in cultured mouse cerebellar granule neurons. Dev Brain Res 2000; 119: 1-10.
47. Kato K, Puttfarcken PS, Lyons WE, Coyle JT. Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures. J Pharmacol Exp Ther 1991; 256: 402-411.
48. Resink A, Hack N, Boer GJ, Balazs R. Growth conditions differentially modulate the vulnerability of developing cerebellar granule cells to excitatory amino acids. Brain Res 1994; 655: 222-232.
49. Belcher SM, Howe JR. Characterization of RNA editing of the glutamate-receptor subunits GluR5 and GluR6 in granule cells during cerebellar development. Mol Brain Res 1997; 52: 130-138.
50. Ripellino JA, Neve RL, Howe JR. Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. Neuroscience 1998; 82: 485-497.
51. 2+] in cultured mouse and rat cerebellar granule cells. Int J Dev Neurosci 2000; 18: 61-68.
52. 3H]aspartate release. J Neurochem 1992; 58: 406-415.
53. Savidge JR, Bleakman D, Bristow DR. Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells. J Neurochem 1997; 69: 1763-1766.
54. Giardina SF, Beart PM. Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors. Br J Pharmacol 2002; 135: 1733-1742.
55. Griffiths R, Malcolm C, Ritchie L, Frandsen A, Schousboe A, Scott M, et al. Association of c-fos mRNA expression and excitotoxicity in primary cultures of mouse neocortical and cerebellar neurons. J Neurosci Res 1997; 48: 533-542.
56. Chiang LW, Grenier JM, Ettwiller L, Jenkins LP, Ficenec D, Martin J, et al. An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis. Proc Natl Acad Sci USA 2001; 98: 2814-2819.
57. Cheung NS, Carroll FY, Larm JA, Beart PM, Giardina SF. Kainate-induced apoptosis correlates with c-Jun activation in cultured cerebellar granule cells. J Neurosci Res 1998; 52: 69-82.
58. Sassone-Corsi P, Ransone LJ, Lamph WW, Verma IM. Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain. Nature 1988; 336: 692-695.
59. Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997; 9: 240-246.
60. Johnston CA, Kennedy SM, Twitchin B. Action of the neurotoxin kainic acid on high affinity uptake of L-glutamic acid in rat brain slices. J Neurochem 1979; 32: 121-127.
61. Lodge D, Johnston GA, Curtis DR, Bornstein JC. Kainate neurotoxicity and glutamate inactivation. Neurosci Lett 1979; 14: 343-348.
62. Gegelashvili G, Schousboe A. High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol 1997; 52: 6-15.
63. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001; 65: 1-105.
64. Rogers KL, Philibert RA, Dutton GR. Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture. Eur J Pharmacol 1990; 177: 195-199.
65. Simonian NA, Getz RL, Leveque JC, Konradi C, Coyle JT. Kainic acid induces apoptosis in neurons. Neuroscience 1996; 75: 1047-1055.
66. Ha BK, Vicini S, Rogers RC, Bresnahan JC, Burry RW, Beattie MS. Kainate-induced excitotoxicity is dependent upon extracellular potassium concentrations that regulate the activity of AMPA/ KA type glutamate receptors. J Neurochem 2002; 83: 934-945.
67. Favaron M, Manev H, Alho H, Bertolino M, Ferret B, Guidotti A, et al. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci USA 1988; 85: 7351-7355.
68. 2+ influx elicited by glutamate: role in neuronal death. Mol Pharmacol 1989; 36: 106-112.
69. Balazs R, Hack N, Jorgensen OS. Selective stimulation of excitatory amino acid receptor subtypes and the survival of cerebellar granule cells in culture - effect of kainic acid. Neuroscience 1990; 37: 251-258.
70. Van der Valk JB, Resink A, Balazs R. Membrane depolarization and the expression of glutamate receptors in cerebellar granule cells. Eur J Pharmacol 1991; 201: 247-250.
71. Pizzi M, Fallacara C, Arrighi V, Memo M, Spano PF. Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells. J Neurochem 1993; 61: 683-689.
72. Facchinetti F, Hack NJ, Balazs R. Calcium influx via ionotropic glutamate receptors causes long lasting inhibition of metabotropic glutamate receptor-coupled phosphoinositide hydrolysis. Neurochem Int 1998; 33: 263-270.
73. Chen Q, Moulder K, Tenkova T, Hardy K, Olney JW, Romano C. Excitotoxic cell death dependent on inhibitory receptor activation. Exp Neurol 1999; 160: 215-225.
74. A receptor β2-α6-α1-γ2 subunit gene cluster. Mol Cell Neurosci 2000; 16: 34-41.
75. A receptor alpha 6 subunit gene (Gabra6) is tightly linked to the α1-γ2 subunit cluster on mouse chromosome 11. Mol Brain Res 1997; 45: 133-137.
76. Chapman AG. Glutamate receptors in epilepsy. Prog Brain Res 1998; 116: 371-383.
77. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999; 22: 391-397.
78. Dodd PR, Beckmann AM, Davidson MS, Wilce PA. Glutamate-mediated transmission, alcohol, and alcoholism. Neurochem Int 2000; 37: 509-533.