메뉴 건너뛰기




Volumn 68, Issue , 1997, Pages 153-174

Antitumor activities of IL-12 and mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12;

EID: 0030955210     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: 10.1159/000058690     Document Type: Review
Times cited : (59)

References (103)
  • 1
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G: Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-276.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 3
    • 0030024797 scopus 로고    scopus 로고
    • Interleukin-12, an integral cytokine in the immune response
    • Stern AS, Magram J, Presky DH: Interleukin-12, an integral cytokine in the immune response. Life Sci 1996;58:639-654.
    • (1996) Life Sci , vol.58 , pp. 639-654
    • Stern, A.S.1    Magram, J.2    Presky, D.H.3
  • 5
    • 0025774767 scopus 로고
    • Natural killer cell stimulatory factor augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines
    • Lieberman MD, Sigal RK, Williams NN, Daly JM: Natural killer cell stimulatory factor augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines. J Surg Res 1991;50:410-415.
    • (1991) J Surg Res , vol.50 , pp. 410-415
    • Lieberman, M.D.1    Sigal, R.K.2    Williams, N.N.3    Daly, J.M.4
  • 7
    • 0028084718 scopus 로고
    • Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12
    • Rossi AR, Pericle F, Rasleigh S, Janiec J, Djeu JY: Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12. Blood 1994;83:1323-1328.
    • (1994) Blood , vol.83 , pp. 1323-1328
    • Rossi, A.R.1    Pericle, F.2    Rasleigh, S.3    Janiec, J.4    Djeu, J.Y.5
  • 9
    • 0027441850 scopus 로고
    • Interleukin-12 augments cytolytic activity of peripheral blood lymphocytes from patients with hematologic and solid malignancies
    • Soiffer RJ, Robertson MJ, Murray C, Cochran K, Ritz J: Interleukin-12 augments cytolytic activity of peripheral blood lymphocytes from patients with hematologic and solid malignancies. Blood 1993;82:2790-2796.
    • (1993) Blood , vol.82 , pp. 2790-2796
    • Soiffer, R.J.1    Robertson, M.J.2    Murray, C.3    Cochran, K.4    Ritz, J.5
  • 11
    • 0027483008 scopus 로고
    • Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: Implications for the immunotherapy of cancer
    • Zeh HJ, Hurd S, Storkus WJ, Lotze MT: Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: Implications for the immunotherapy of cancer. J Immunother 1993;14:155-161.
    • (1993) J Immunother , vol.14 , pp. 155-161
    • Zeh, H.J.1    Hurd, S.2    Storkus, W.J.3    Lotze, M.T.4
  • 12
    • 0029039610 scopus 로고
    • Systemic administration of rIL-2 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-gamma production by antitumor T cells
    • Zou JP, Yamamoto N, Fujii T, Takenaka H, Kobayashi M, Herrmann SH, Wolf SF, Fujiwara H, Hamaoka T: Systemic administration of rIL-2 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-gamma production by antitumor T cells. Int Immunol 1995;7:1135-1145.
    • (1995) Int Immunol , vol.7 , pp. 1135-1145
    • Zou, J.P.1    Yamamoto, N.2    Fujii, T.3    Takenaka, H.4    Kobayashi, M.5    Herrmann, S.H.6    Wolf, S.F.7    Fujiwara, H.8    Hamaoka, T.9
  • 15
    • 0029968664 scopus 로고    scopus 로고
    • Natural killer cells and interleukin-12 in patients with advanced cervical cancer under neoadjuvant chemotherapy
    • Marana HR, Andrade JM, Silva JS: Natural killer cells and interleukin-12 in patients with advanced cervical cancer under neoadjuvant chemotherapy. Braz J Med Biol Res 1996;29:473-477.
    • (1996) Braz J Med Biol Res , vol.29 , pp. 473-477
    • Marana, H.R.1    Andrade, J.M.2    Silva, J.S.3
  • 18
    • 0029009835 scopus 로고
    • Costimulation with B7-1, IL-6 and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro
    • Gajewski TF, Renauld JC, Van Pel A, Boon T: Costimulation with B7-1, IL-6 and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro. J Immunol 1995;154: 5637-5648.
    • (1995) J Immunol , vol.154 , pp. 5637-5648
    • Gajewski, T.F.1    Renauld, J.C.2    Van Pel, A.3    Boon, T.4
  • 19
    • 0003140089 scopus 로고
    • Effect of in vivo IL-12 administration on murine tumour cell growth
    • O'Toole M, Wolf S, O'Brien C, Hubbard B, Hermann S: Effect of in vivo IL-12 administration on murine tumour cell growth. J Immunol 1993;150:294A.
    • (1993) J Immunol , vol.150
    • O'Toole, M.1    Wolf, S.2    O'Brien, C.3    Hubbard, B.4    Hermann, S.5
  • 21
    • 0030641489 scopus 로고    scopus 로고
    • Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice
    • Handel-Fernandez ME, Gheng X, Herbert LM, Lopez DM: Down-regulation of IL-12, not a shift from a T helper-1 to a T helper-2 phenotype, is responsible for impaired IFN-gamma production in mammary tumor-bearing mice. J Immunol 1997;158:280-286.
    • (1997) J Immunol , vol.158 , pp. 280-286
    • Handel-Fernandez, M.E.1    Gheng, X.2    Herbert, L.M.3    Lopez, D.M.4
  • 23
    • 0030451123 scopus 로고    scopus 로고
    • Apoptosis induced by interleukin-12 measured by DNA electrophoresis and in situ end labeling in leukemia
    • Stine KC, Warren BA, Becton DL: Apoptosis induced by interleukin-12 measured by DNA electrophoresis and in situ end labeling in leukemia. Ann NY Acad Sci 1996;795:420-421.
    • (1996) Ann NY Acad Sci , vol.795 , pp. 420-421
    • Stine, K.C.1    Warren, B.A.2    Becton, D.L.3
  • 25
    • 0029909109 scopus 로고    scopus 로고
    • Effect of interleukin 12 on tumor induction by 3-methylcholanthrene
    • Noguchi Y, Jungbluth A, Richards EC, Old L: Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc Natl Acad Sci USA 1996;93:11798-11801.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11798-11801
    • Noguchi, Y.1    Jungbluth, A.2    Richards, E.C.3    Old, L.4
  • 29
    • 0029090220 scopus 로고
    • Administration of recombinant interleukin-12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes
    • Mu J, Zou JP, Yamamoto N, Tsutsui T, Tai XG, Kobayashi M, Herrmann S, Fujiwara H, Hamaoka T: Administration of recombinant interleukin-12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes. Cancer Res 1995;55:4404-4408.
    • (1995) Cancer Res , vol.55 , pp. 4404-4408
    • Mu, J.1    Zou, J.P.2    Yamamoto, N.3    Tsutsui, T.4    Tai, X.G.5    Kobayashi, M.6    Herrmann, S.7    Fujiwara, H.8    Hamaoka, T.9
  • 30
  • 31
    • 0029912787 scopus 로고    scopus 로고
    • Interleukin-12 augments the liver-associated immunity and reduces liver metastases
    • Okuno K, Jinnai H, Lee YS, Kaneda K, Yasutomi M: Interleukin-12 augments the liver-associated immunity and reduces liver metastases. Hepatogastroenterology 1996;43:1196-1202.
    • (1996) Hepatogastroenterology , vol.43 , pp. 1196-1202
    • Okuno, K.1    Jinnai, H.2    Lee, Y.S.3    Kaneda, K.4    Yasutomi, M.5
  • 36
    • 0028944328 scopus 로고
    • Influence of IL-12 on p53 peptide vaccination against established Meth-A sarcoma
    • Noguchi Y, Richards EC, Chen Y, Old LJ: Influence of IL-12 on p53 peptide vaccination against established Meth-A sarcoma. Proc Natl Acad Sci USA 1995;92:2219-2223.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2219-2223
    • Noguchi, Y.1    Richards, E.C.2    Chen, Y.3    Old, L.J.4
  • 39
    • 0029885750 scopus 로고    scopus 로고
    • IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: Enhancement by simultaneous B7-1 expression
    • Rao JB, Chamberlain RS, Bronte V, Carroll MW, Irvine KR, Moss B, Rosenberg SA, Restifo NP: IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: Enhancement by simultaneous B7-1 expression. J Immunol 1996;156:3357-3365.
    • (1996) J Immunol , vol.156 , pp. 3357-3365
    • Rao, J.B.1    Chamberlain, R.S.2    Bronte, V.3    Carroll, M.W.4    Irvine, K.R.5    Moss, B.6    Rosenberg, S.A.7    Restifo, N.P.8
  • 44
    • 0030022796 scopus 로고    scopus 로고
    • Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases
    • Irvine KR, Rao JB, Rosenberg SA, Restifo NP: Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J Immunol 1996;156:238-245.
    • (1996) J Immunol , vol.156 , pp. 238-245
    • Irvine, K.R.1    Rao, J.B.2    Rosenberg, S.A.3    Restifo, N.P.4
  • 45
    • 0029153750 scopus 로고
    • Addition of interleukin-12 to low dose interleukin-2 treatment improves antitumor efficacy in vivo
    • Leder GH, Oppenheim M, Rosenstein M, Lotze MT, Beger HG: Addition of interleukin-12 to low dose interleukin-2 treatment improves antitumor efficacy in vivo. Z Gastroenterol 1995;33:499-505.
    • (1995) Z Gastroenterol , vol.33 , pp. 499-505
    • Leder, G.H.1    Oppenheim, M.2    Rosenstein, M.3    Lotze, M.T.4    Beger, H.G.5
  • 47
    • 0030028620 scopus 로고    scopus 로고
    • In vivo studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment
    • Teicher BA, Ara G, Menon K, Schaub RG: In vivo studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment. Int J Cancer 1996;65:80-84.
    • (1996) Int J Cancer , vol.65 , pp. 80-84
    • Teicher, B.A.1    Ara, G.2    Menon, K.3    Schaub, R.G.4
  • 51
    • 0029868353 scopus 로고    scopus 로고
    • IL-12: A key cytokine in immune regulation
    • Lamont AG, Adorini L: IL-12: A key cytokine in immune regulation. Immunol Today 1996;17: 214-217.
    • (1996) Immunol Today , vol.17 , pp. 214-217
    • Lamont, A.G.1    Adorini, L.2
  • 53
    • 0000824394 scopus 로고
    • Cancer trial of interleukin-12 halted
    • Marshall E: Cancer trial of interleukin-12 halted. Science 1995;268:1555.
    • (1995) Science , vol.268 , pp. 1555
    • Marshall, E.1
  • 54
    • 1842271190 scopus 로고    scopus 로고
    • Antitumor effects in patients with melanoma, head and neck carcinoma and breast cancer in Phase I/II clinical trials of interleukin-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts
    • in press
    • Tahara H, Zitvogel L, Storkus WJ, Elder EM, Kinzler D, Whiteside TL, Robbins PD, Lotze MT: Antitumor effects in patients with melanoma, head and neck carcinoma and breast cancer in Phase I/II clinical trials of interleukin-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts. Proc ASCO 1997, in press.
    • (1997) Proc ASCO
    • Tahara, H.1    Zitvogel, L.2    Storkus, W.J.3    Elder, E.M.4    Kinzler, D.5    Whiteside, T.L.6    Robbins, P.D.7    Lotze, M.T.8
  • 56
    • 0028837129 scopus 로고
    • Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy
    • Pappo I, Tahara H, Robbins PD, Gately MK, Wolf SF, Barnea A, Lotze MT: Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy. J Surg Res 1995;58:218-226.
    • (1995) J Surg Res , vol.58 , pp. 218-226
    • Pappo, I.1    Tahara, H.2    Robbins, P.D.3    Gately, M.K.4    Wolf, S.F.5    Barnea, A.6    Lotze, M.T.7
  • 57
    • 0030058647 scopus 로고    scopus 로고
    • Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation and T helper cell 1-associated cytokines
    • Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT: Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation and T helper cell 1-associated cytokines. J Exp Med 1996;183:87-97.
    • (1996) J Exp Med , vol.183 , pp. 87-97
    • Zitvogel, L.1    Mayordomo, J.I.2    Tjandrawan, T.3    DeLeo, A.B.4    Clarke, M.R.5    Lotze, M.T.6
  • 58
    • 0027953555 scopus 로고
    • Fibroblasts genetically engineered to secrete interleukin-12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
    • Tahara H, Zeh H Jr, Storkus WJ, Pappo J, Watkins SC, Gubler U, Wolf SF, Robbins PD, Lotze MT: Fibroblasts genetically engineered to secrete interleukin-12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res 1994;54:182-189.
    • (1994) Cancer Res , vol.54 , pp. 182-189
    • Tahara, H.1    Zeh Jr., H.2    Storkus, W.J.3    Pappo, J.4    Watkins, S.C.5    Gubler, U.6    Wolf, S.F.7    Robbins, P.D.8    Lotze, M.T.9
  • 60
    • 0030589377 scopus 로고    scopus 로고
    • Immunotherapy of experimental me;tastases by vaccination with interleukin gene-transduced tumor cell vaccines
    • Rodolfo M, Zilocchi C, Melani C, Cappetti B, Arioli I, Parmiani G, Colombo MP: Immunotherapy of experimental me;tastases by vaccination with interleukin gene-transduced tumor cell vaccines. J Immunol 1996;157:5536-5542.
    • (1996) J Immunol , vol.157 , pp. 5536-5542
    • Rodolfo, M.1    Zilocchi, C.2    Melani, C.3    Cappetti, B.4    Arioli, I.5    Parmiani, G.6    Colombo, M.P.7
  • 61
    • 0029823656 scopus 로고    scopus 로고
    • Cytokine production and anti-tumor effect of a nonreplicating, noncytopathic recombinant vaccinia virus expressing interleukin-12
    • Meko JB, Tsung K, Norton JA: Cytokine production and anti-tumor effect of a nonreplicating, noncytopathic recombinant vaccinia virus expressing interleukin-12. Surgery 1996;120:274-282.
    • (1996) Surgery , vol.120 , pp. 274-282
    • Meko, J.B.1    Tsung, K.2    Norton, J.A.3
  • 62
    • 0030474719 scopus 로고    scopus 로고
    • Tumor cells transfected with B7-1 and interleukin-12 cDNA induce protective immunity
    • 62a Chen PW, Geer DC, Podack ER, Ksander BR: Tumor cells transfected with B7-1 and interleukin-12 cDNA induce protective immunity. Ann NY Acad Sci 1996;795:325-327.
    • (1996) Ann NY Acad Sci , vol.795 , pp. 325-327
    • Chen, P.W.1    Geer, D.C.2    Podack, E.R.3    Ksander, B.R.4
  • 63
    • 0029947820 scopus 로고    scopus 로고
    • Gene gun-mediated skin transfection with interleukin-12 gene results in regression of established primary and metastatic murine tumors
    • 62b Rakhmilevich AL, Turner J, Ford MJ, McCabe D, Sun WH, Sondel PM, Grota K, Yang NS: Gene gun-mediated skin transfection with interleukin-12 gene results in regression of established primary and metastatic murine tumors. Proc Natl Acad Sci USA 1996;93:6291-6296.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6291-6296
    • Rakhmilevich, A.L.1    Turner, J.2    Ford, M.J.3    McCabe, D.4    Sun, W.H.5    Sondel, P.M.6    Grota, K.7    Yang, N.S.8
  • 64
    • 0030057511 scopus 로고    scopus 로고
    • Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12
    • Bramson J, Hitt M, Gallichan WS, Rosenthal KL, Gauldie J, Graham FL: Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12. Hum Gene Ther 1996;7:333-342.
    • (1996) Hum Gene Ther , vol.7 , pp. 333-342
    • Bramson, J.1    Hitt, M.2    Gallichan, W.S.3    Rosenthal, K.L.4    Gauldie, J.5    Graham, F.L.6
  • 67
    • 0027368542 scopus 로고
    • Impaired activation of tumoricidal function in macrophages from mammary tumor bearers: The role of IFN-γ
    • Sotomayor EM, Cheng XF, Fu YX, Hawkins A, Calderon-Higginson C, Lopez DM: Impaired activation of tumoricidal function in macrophages from mammary tumor bearers: The role of IFN-γ. Int J Oncol 1993;3:719-722.
    • (1993) Int J Oncol , vol.3 , pp. 719-722
    • Sotomayor, E.M.1    Cheng, X.F.2    Fu, Y.X.3    Hawkins, A.4    Calderon-Higginson, C.5    Lopez, D.M.6
  • 70
    • 0029029597 scopus 로고
    • AK-5 tumor-induced expression of interleukin-12: Role of IL-12 in NK-mediated AK-5 regression
    • Hegde SP, Bright JJ, Kausalya S, Khar A: AK-5 tumor-induced expression of interleukin-12: Role of IL-12 in NK-mediated AK-5 regression. Cell Immunol 1995;162:241-247.
    • (1995) Cell Immunol , vol.162 , pp. 241-247
    • Hegde, S.P.1    Bright, J.J.2    Kausalya, S.3    Khar, A.4
  • 72
    • 1842321128 scopus 로고
    • Interleukin-12 induces specific antitumor immunity in animals bearing established subcutaneous murine sarcoma
    • Nastala CL, McKinney TJ, Edington HD, Tahara H, Storkus WJ, Lotze MT: Interleukin-12 induces specific antitumor immunity in animals bearing established subcutaneous murine sarcoma. Surg Forum 1994;45:492-494.
    • (1994) Surg Forum , vol.45 , pp. 492-494
    • Nastala, C.L.1    McKinney, T.J.2    Edington, H.D.3    Tahara, H.4    Storkus, W.J.5    Lotze, M.T.6
  • 73
    • 0029188099 scopus 로고
    • Interleukin-12: Potential role in cancer therapy
    • DeVita VT, Hellman S, Rosenberg SA (eds): Philadelphia, Lippincott
    • Brunda MJ, Gately MK: Interleukin-12: Potential role in cancer therapy; in DeVita VT, Hellman S, Rosenberg SA (eds): Important Adv Oncol 1995. Philadelphia, Lippincott, 1995, pp 3-18.
    • (1995) Important Adv Oncol 1995 , pp. 3-18
    • Brunda, M.J.1    Gately, M.K.2
  • 75
    • 0029814589 scopus 로고    scopus 로고
    • Antitumor and antimetastatic effects of interleukin-12
    • Fujiwara H, Hamaoka T: Antitumor and antimetastatic effects of interleukin-12. Cancer Chemother Pharmacol 1996;38(suppl):22-26.
    • (1996) Cancer Chemother Pharmacol , vol.38 , Issue.SUPPL. , pp. 22-26
    • Fujiwara, H.1    Hamaoka, T.2
  • 76
    • 0030056840 scopus 로고    scopus 로고
    • Interleukin-12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: Implications for the antitumor activity of interleukin-12 and/or interleukin-2
    • Wigginton JM, Kuhns DB, Back TC, Brunda M, Wiltrout RH, Cox GW: Interleukin-12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: Implications for the antitumor activity of interleukin-12 and/or interleukin-2. Cancer Res 1996;56:1131-1136.
    • (1996) Cancer Res , vol.56 , pp. 1131-1136
    • Wigginton, J.M.1    Kuhns, D.B.2    Back, T.C.3    Brunda, M.4    Wiltrout, R.H.5    Cox, G.W.6
  • 77
    • 0027965621 scopus 로고
    • Tumor-associated macrophages in neoplastic progression: A paradigm for the in vivo function of chemokines
    • Mantovani A: Tumor-associated macrophages in neoplastic progression: A paradigm for the in vivo function of chemokines. Lab Invest 1994;71:5-16.
    • (1994) Lab Invest , vol.71 , pp. 5-16
    • Mantovani, A.1
  • 78
    • 0028302827 scopus 로고
    • Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms
    • Cui S, Reichner JS, Mateo RB, Albina JE: Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res 1994;54: 2462-2467.
    • (1994) Cancer Res , vol.54 , pp. 2462-2467
    • Cui, S.1    Reichner, J.S.2    Mateo, R.B.3    Albina, J.E.4
  • 80
    • 0028500836 scopus 로고
    • Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN-gamma receptors
    • Dighe AS, Richards E, Old LS, Schreiber RD: Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN-gamma receptors. Immunity 1994;1:447-456.
    • (1994) Immunity , vol.1 , pp. 447-456
    • Dighe, A.S.1    Richards, E.2    Old, L.S.3    Schreiber, R.D.4
  • 82
    • 0029930050 scopus 로고    scopus 로고
    • Apoptosis-independent retinoblastoma protein rescue of HLA class II messenger RNA IFN-gamma inducibility in non-small cell lung carcinoma cells. Lack of surface class II expression associated with a specific defect in HLA-DRA induction
    • Lu Y, Boss JM, Hu SX, Xu HJ, Blanck G: Apoptosis-independent retinoblastoma protein rescue of HLA class II messenger RNA IFN-gamma inducibility in non-small cell lung carcinoma cells. Lack of surface class II expression associated with a specific defect in HLA-DRA induction. J Immunol 1996;156:2495-2502.
    • (1996) J Immunol , vol.156 , pp. 2495-2502
    • Lu, Y.1    Boss, J.M.2    Hu, S.X.3    Xu, H.J.4    Blanck, G.5
  • 83
    • 0027285535 scopus 로고
    • Selectively down-regulated expression of major histocompatibility complex class I alleles in human solid tumor
    • Vegh Z, Wang P, Vanky F, Klein E: Selectively down-regulated expression of major histocompatibility complex class I alleles in human solid tumor. Cancer Res 1993;53(suppl):2416-420.
    • (1993) Cancer Res , vol.53 , Issue.SUPPL. , pp. 2416-2420
    • Vegh, Z.1    Wang, P.2    Vanky, F.3    Klein, E.4
  • 84
    • 0040858936 scopus 로고
    • Induction of indoleamme 2,3-dioxygenase: A mechanism of the antitumor activity of interferon-γ
    • Ozaki Y, Edelstein MP, Duch DS: Induction of indoleamme 2,3-dioxygenase: A mechanism of the antitumor activity of interferon-γ. Proc Natl Acad Sci USA 1988;85:1242.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1242
    • Ozaki, Y.1    Edelstein, M.P.2    Duch, D.S.3
  • 85
    • 0029884816 scopus 로고    scopus 로고
    • Cytokines in animal models of cancer
    • Burke F, Balkwill FR: Cytokines in animal models of cancer. Biotherapy 1996;8:229-241.
    • (1996) Biotherapy , vol.8 , pp. 229-241
    • Burke, F.1    Balkwill, F.R.2
  • 87
    • 0029930406 scopus 로고    scopus 로고
    • Interleukin-12 inhibits angiogenesis induced by human tumor cell lines in vivo
    • Majewski S, Marczak M, Szmurlo A, Jablonska S, Bollag W: Interleukin-12 inhibits angiogenesis induced by human tumor cell lines in vivo. J Invest Dermatol 1996;106:1114-1118.
    • (1996) J Invest Dermatol , vol.106 , pp. 1114-1118
    • Majewski, S.1    Marczak, M.2    Szmurlo, A.3    Jablonska, S.4    Bollag, W.5
  • 89
    • 0028043326 scopus 로고
    • Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri G: Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84:4008-4027.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 90
    • 0029954562 scopus 로고    scopus 로고
    • Dendritic cells presenting tumor antigen
    • Shurin MR: Dendritic cells presenting tumor antigen. Cancer Immunol Immunother 1996;43: 158-164.
    • (1996) Cancer Immunol Immunother , vol.43 , pp. 158-164
    • Shurin, M.R.1
  • 91
    • 0030586543 scopus 로고    scopus 로고
    • IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells
    • Bianchi R, Grohmann U, Belladonna ML, Silla S, Fallarino F, Ayroldi E, Fioretti MC, Puccetti P: IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J Immunol 1996;157:1589-1597.
    • (1996) J Immunol , vol.157 , pp. 1589-1597
    • Bianchi, R.1    Grohmann, U.2    Belladonna, M.L.3    Silla, S.4    Fallarino, F.5    Ayroldi, E.6    Fioretti, M.C.7    Puccetti, P.8
  • 92
    • 0029148905 scopus 로고
    • Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
    • Zitvogel L, Tahara H, Robbins PD, Storkus WJ, Clarke MR, Nalesnik MA, Lotze MT: Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J Immunol 1995;155:1393-1403.
    • (1995) J Immunol , vol.155 , pp. 1393-1403
    • Zitvogel, L.1    Tahara, H.2    Robbins, P.D.3    Storkus, W.J.4    Clarke, M.R.5    Nalesnik, M.A.6    Lotze, M.T.7
  • 94
    • 0030051657 scopus 로고    scopus 로고
    • Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo
    • Fallarino F, Uyttenhove C, Boon T, Gajewski T: Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J Immunol 1996;156:1095-1100.
    • (1996) J Immunol , vol.156 , pp. 1095-1100
    • Fallarino, F.1    Uyttenhove, C.2    Boon, T.3    Gajewski, T.4
  • 95
    • 0029046307 scopus 로고
    • Uptake of micropartide-absorbed protein antigen by hone-marrow derived dendritic cells results in up-regulation of interleukin-1α and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation
    • Scheicher C, Mehlig M, Dienes HP, Reske K: Uptake of micropartide-absorbed protein antigen by hone-marrow derived dendritic cells results in up-regulation of interleukin-1α and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur J Immunol 1995;25:1566-1572.
    • (1995) Eur J Immunol , vol.25 , pp. 1566-1572
    • Scheicher, C.1    Mehlig, M.2    Dienes, H.P.3    Reske, K.4
  • 98
    • 0028824039 scopus 로고
    • IL-12 deaths: Explanation and a puzzle
    • Cohen J: IL-12 deaths: Explanation and a puzzle. Science 1995;270:908.
    • (1995) Science , vol.270 , pp. 908
    • Cohen, J.1
  • 99
    • 0030473466 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying IL-12-induced tumor regression
    • Fujiwara H, Clark SC, Hamaoka T: Cellular and molecular mechanisms underlying IL-12-induced tumor regression. Ann NY Acad Sci 1996;795:294-309.
    • (1996) Ann NY Acad Sci , vol.795 , pp. 294-309
    • Fujiwara, H.1    Clark, S.C.2    Hamaoka, T.3
  • 103
    • 0030067276 scopus 로고    scopus 로고
    • Administration of interleukin-12 pulse interleukin-2 and the rapid and complete eradication of murine renal carcinoma
    • Wigginton JM, Komschlies KL, Back TC, Franco JL, Brunda MJ, Wiltrout RH: Administration of interleukin-12 pulse interleukin-2 and the rapid and complete eradication of murine renal carcinoma. J Natl Cancer lnst 1996;88:38-43.
    • (1996) J Natl Cancer Lnst , vol.88 , pp. 38-43
    • Wigginton, J.M.1    Komschlies, K.L.2    Back, T.C.3    Franco, J.L.4    Brunda, M.J.5    Wiltrout, R.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.