Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-β, and glomerular size in diabetes

Journal of the American Society of Nephrology

Volumn 8, Issue 9, 1997, Pages 1405-1414

  Craven, Patricia A ^a,c   Derubertis, Frederick R ^a,c   Kagan, Valerian E ^b   Melhem, Mona ^a,c   Studer, Rebecca K ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; TOCOPHEROL; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLOMERULOPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY SIZE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEINURIA; RAT; STREPTOZOCIN DIABETES;

EID: 0030784837     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v891405     Document Type: Article

References (88)

1. Hiramatsu K, Arimori S: Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes. Diabetes 37: 832-837, 1988
2. Schroder S, Palinski W, Schmid-Schonbein GW: Activated monocytes and granulocytes, capillary nonperfusion and neovascularization in diabetic retinopathy. Am J Pathol 139: 81-100, 1991
3. Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D: Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269: 9889-9897, 1984
4. Wolf SP, Dean RT: Glucose autoxidation and protein modification: The potential role of oxidative glycosylation in diabetes. Biochem J 245: 243-250, 1987
5. Hunt JV, Smith CCT, Wolff SP: Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39: 1420-1424, 1990
6. Hunt JV, Dean RT, Wolff SP: Hydroxyl radical production and autoxidative glycosylation: Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing. Biochem J 256: 205-212, 1988
7. Tesfamariam B, Jakubowski JA, Cohen RA: Contraction of diabetic rabbit aorta caused by endothelium derived PGH2: TXA2. Am J Physiol 257: H1327-H1333, 1989
8. Tesfamariam B, Brown D, Deykin D, Cohen RA: Elevated glucose promotes generation of endothelium derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest 85: 929-932, 1990
9. Kukreja RC, Kontos HA, Hess MZ, Ellis EF: PGH synthase and lipoxygenase generate superoxide in the presence of NADH and NADPH. Circ Res 59: 612-619, 1986
10. Kontos HA: Oxygen radicals from arachidonate metabolism in abnormal vascular responses. Am Rev Respir Dis 136: 474-477, 1987
11. Sing DJ, Greenwald J, Metz EN, Bianchine J, Sagone AL: Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. Am J Hematol 11: 233-237, 1981
12. Sinclair AJ, Girling AJ, Gray L, LeGuen C, Barnett AH: Disturbed handling of ascorbic acid in diabetic patients with and without microangiopathy during high dose ascorbate supplementation. Diabetologia 34: 171-175, 1991
13. Paolisso G, D'Amore A, Balbi V, Volpe C, Galzerano D, Giugliano D, Sgambato S, Varricchio M, D'Onofrio F: Plasma vitamin C affects glucose homeostasis in healthy subjects and in noninsulin dependent diabetics. Am J Physiol 266: E261-E268, 1994
14. Paolisso G, Balbi V, Volpe C, Varricchio G, Gambardella A, Saccomanno F, Ammendola S, Varricchio M, D'Onofrio F: Metabolic benefits deriving from chronic vitamin c supplementation in aged noninsulin dependent diabetics. J Am Coll Nutr 14: 387-392, 1995
15. Ndahimana J, Dorchy H, Vertongen F: Erythrocyte and plasma antioxidant activity in type I diabetes mellitus. Presse Med 25: 188-192, 1996
16. Sundaram RK, Bhaskar A, Vijayalingam S, Viswanathan M, Mohan R, Shanmugasundaram KR: Antioxidant status and lipid peroxidation in type II diabetes mellitus with and without complications. Clin Sci 90: 255-260, 1996
17. Yue DK, McLennan S, Fisher E, Heffernan S, Capogreco C, Ross GR, Turtle JR: Ascorbic acid metabolism and polyol pathway in diabetes. Diabetes 38: 257-261, 1989
18. DiMattio J: Alterations in ascorbic acid transport into the lens of streptozotocin induced diabetic rats and guinea pigs. Invest Ophthalmol Visual Sci 33: 2926-2935, 1992
19. Bode AM, Yavarow CR, Fry DA, Vargas T: Enzymatic basis for altered ascorbic acid and dehydroascorbic acid levels in diabetes. Biochem Biophys Res Commun 191: 1347-1353, 1993
20. Young IS, Tate S, Lightbody JH, McMaster D, Trimble ER: The effects of desferrioxamine and ascorbate on oxidative stress in the streptozotocin diabetic rat. Free Radical Biol Med 18: 833-840, 1995
21. Meister A: Glutathione ascorbic acid antioxidant system in animals. J Biol Chem 269: 9397-9400, 1994
22. Altan N, Ongun CO, Elmali E, Kilic N, Yavuz O, Cayci B: Effect of the sulfonylurea glyburide on glutathione and glutathione peroxidase activity in alloxan induced diabetic rat hepatocytes. Gen Pharmacol 25: 875-878, 1994
23. Mukherjee B, Mukherjee JR, Chatterjee M: Lipid peroxidation, glutathione levels and changes in glutathione related enzyme activities in streptozotocin induced diabetic rats. Immunol Cell Biol 72: 109-114, 1994
24. Ewis SA, Abdelrahman MS: Effect of metformin on glutathione and magnesium in normal and streptozotocin induced diabetic rats. J Appl Toxicol 15: 387-390, 1995
25. Paolisso G, DiMaro G, Pizza G, D'Amore A, Sgambato S, Tesauro P, Varricchio M, D'Onofrio F: Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non insulin dependent diabetics. Am J Physiol 263: E435-E440, 1992
26. Jain SK, McVie R: Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients. Metab Clin Exp 43: 306-309, 1994
27. Yoshida K, Hirokawa J, Tagami S, Kawakami Y, Urata Y, Kondo T: Weakened cellular scavenging activity against oxidative stress in diabetes mellitus regulation of glutathione synthesis and efflux. Diabetologia 38: 201-210, 1995
28. Thomas SR, Neuzil J, Mohr D, Stocker R: Coantioxidants make α tocopherol an efficient antioxidant for low density lipoprotein. Am J Clin Nutr 62: 1357S-1364S, 1995
29. Frei B, England L, Ames BN: Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381, 1989
30. Paolisso G, D'Amore A, Giugliano D, Ceriello A, Varricchio M, D'Onofrio F: Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57: 650-656, 1993
31. Ceriello A, Giugliano D, Quatraro A, Donzella C, DiPalo G, Lefebure PJ: Vitamin E reduction of protein glycosylation in diabetes. Diabetes Care 14: 68-72, 1991
32. Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H, Low PA: Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18: 1160-1167, 1995
33. Giardino E, Edelstein D, Horiuchi A, Araki N, Brownlee M: Vitamin E prevents diabetes-induced formation of arterial wall intracellular advanced glycation end products [Abstract]. Diabetes 94: 73A, 1995
34. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA: Vitamin C improves endothelium dependent vasodilation in patients with noninsulin dependent diabetes mellitus. J Clin Invest 97: 22-28, 1996
35. Giugliano D, Marfella R, Verrazzo G, Acampora R, Donzella C, Quatraro A, Coppola L, D'Onofrio F: Abnormal rheologic effects of glyceryl trinitrate in patients with noninsulin dependent diabetes mellitus and reversal by antioxidants. Ann Intern Med 123: 338-343, 1995
36. Kahler W, Kuklinski B, Ruhlmann C, Plotz C: Diabetes mellitus: A free-radical associated disease. Results of an adjuvant antioxidant supplementation. Innere Medizin 48: 223-232, 1993
37. Ho H, Kim KH: Role of oxidative stress in the development of diabetic nephropathy. Kidney Int 48: S18-S21, 1995
38. Beyer-Mears A, Cruz E, Kowluru R, Engerman R, Kern J: Short-term effects of vitamin C plus E on diabetic albuminuria and proteinuria [Abstract]. Diabetes 45: 206A, 1996
39. Trachtman H, Futterweit S, Maesaka J, Ma C, Valderrama E, Fuchs A, Tarectecan AA, Rao PS, Sturman JA, Boles TH, Fu MX, Baynes J: Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats. Am J Physiol 269: F429-F438, 1995
40. Steffes MW, Osterby R, Chavers B, Mauer SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 38: 1077-1081, 1989
41. Sharma K, Ziyadeh FN: The emerging role of transforming growth factor β in kidney disease. Am J Physiol 266: F829-F842, 1994
42. Craven PA, Melhem MF, DeRubertis FR: Thromboxane in the pathogenesis of glomerular injury in diabetes. Kidney Int 42: 937-946, 1992
43. Wang J, Robbins ME: Radiation-induced alteration of rat mesangial cell transforming growth factor beta and expression of the genes associated with the extracellular matrix. Radiat Res 146: 561-568, 1996
44. Grandis JR, Melhem MF, Barnes EL, Tweardy DJ: Quantitative immunohistochemical analysis of transforming growth factor alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer (Phila) 78: 1284-1292, 1996
45. Studer RK, Craven PA, DeRubertis FR: Low density lipoprotein stimulation of mesangial cell fibronectin synthesis: Role of protein kinase C and transforming growth factor β. J Lab Clin Med 125: 86-95, 1995
46. Studer RK, Negrete H, Craven PA, DeRubertis FR: Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGFβ bioactivity in mesangial cells. Kidney Int 48: 422-430, 1995
47. Elsayed NM, Tyurina YY, Tyurin VA, Menshikova EV, Kisin ER, Kagan VE: Antioxidant depletion, lipid peroxidation and impairment of calcium transport induced by air blast overpressure in rat lungs. Exp Lung Res 22: 179-200, 1996
48. Zannoni V, Lynch M, Goldstein S, Sato PA: Rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem Med 11: 42-48, 1974
49. Yamamoto T, Noble NA, Cohen AH, Nast CC, Hishida A, Gold LI, Border WA: Expression of transforming growth factor β isoforms in human glomerular diseases. Kidney Int 49: 461-469, 1996
50. Shankland SJ, Scholey JW: Expression of transforming growth factor β1 during diabetic renal hypertrophy. Kidney Int 46: 430-442, 1994
51. Ohno M, Cooke JP, Dzau VJ, Gibbons GH: Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. J Clin Invest 95: 1363-1369, 1995
52. Ziyadeh FN, Sharma K, Erickson M, Wolf G: Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor β1. J Clin Invest 93: 536-542, 1994
53. Young BA, Johnson RJ, Apers CE, Eng E, Gordon K, Floege J, Couser WG: Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 47: 935-944, 1995
54. MacKay K, Striker LJ, Stauffer JW, Doi T, Agodos LY, Striker GE: Transforming growth factor β: Murine glomerular receptors and responses of isolated glomerular cells. Kidney Int 38: 1095-1100, 1990
55. Kasinath BS: Glomerular endothelial cell proteoglycans: Regulation by TGFβ1. Arch Biochem Biophys 305: 370-377, 1993
56. Nakamura T, Miller D, Ruoslahti E, Border WA: Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor beta 1. Kidney Int 41: 1213-1221, 1992
57. Sharma K, Ziyadeh FN: Renal hypertrophy is associated with upregulation of TGFβ1 gene expression in diabetic BB rat and NOD mouse. Am J Physiol 267: F1094-F1101, 1994
58. Wolf G, Mueller E, Stahl AK, Ziyadeh FN: Angiotensin II induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous TGFβ. J Clin Invest 92: 1366-1373, 1993
59. Trachtman H, Chan JC, Chan W, Valderrama E, Brandt R, Wakely P, Futterweit S, Maesaka J, Ma C: Vitamin E ameliorates renal injury in an experimental model of immunoglobulin A nephropathy. Pediatr Res 40: 620-626, 1996
60. Craven PA, DeRubertis FR: Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: Possible mediation by glucose. J Clin Invest 83: 1667-1675, 1989
61. Craven PA, Davidson CM, DeRubertis FR: Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 39: 667-674, 1990
62. Studer RK, Craven PA, DeRubertis FR: Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high glucose medium. Diabetes 42: 188-226, 1993
63. Ayo SH, Radnik R, Garoni JA, Troyer DA, Kreisberg JI: High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures. Am J Physiol 261: F571-F577, 1991
64. Kagami S, Border WA, Mille DE, Noble NA: Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor β expression in rat glomerular mesangial cells. J Clin Invest 64: 2431-2437, 1994
65. Fumo P, Kuncio GS, Ziyadeh FN: PKC and high glucose stimulate collagen α1 IV transcriptional activity in a reporter mesangial cell line. Am J Physiol 267: F632-F638, 1994
66. Kunisake M, Bursell S-E, Umeda R, Nawata H, King GL: Normalization of diacylglycerol protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 43: 1372-1377, 1994
67. Kunisake M, Bursell S-E, Clermone AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL: Vitamin E prevents diabetes induced abnormal retinal blood flow via the diacylglycerol protein kinase C pathway. Am J Physiol 269: E239-E246, 1995
68. Koya D, Ishii H, King GL: Prevention of glomerular hyperfiltration in diabetic rats through the inhibition of DAG-PKC signaling by vitamin E [Abstract]. J Am Soc Nephrol 6: 1042, 1995
69. Gschwendt M, Kittstein W, Marks F: Protein kinase C activation by phorbol esters: Do cysteine rich regions and pseudosubstrate motifs play a role? Trends Biochem Sci 16: 167-169, 1991
70. Larsson R, Cerutti P: Translocation and enhancement of phosphotransferase activity of: protein kinase C following exposure in mouse epidermal cells to oxidants. Cancer Res 49: 5627-5632, 1989
71. Gopalkrishna R, Anderson WB: Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys 285: 382-387, 1991
72. Palumbo EJ, Sweatt JD, Chen S-J, Klann E: Oxidation induced persistent activation of protein kinase C in hippocampal homogenates. Biochem Biophys Res Commun 187: 1439-1445, 1992
73. Studer RK, Craven PA, DeRubertis FR: Inhibition by α tocopherol of increases in transforming growth factor β induced by high glucose and thromboxane in mesangial cells [Abstract]. J Am Soc Nephrol 6: 1048, 1995
74. Trachtman H: Vitamin E prevents glucose induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Microvasc Res 47: 232-239, 1994
75. Trachtman H, Futterweit S, Prenner J, Hanon S: Antioxidants reverse the antiproliferative effect of high glucose and advanced glycosylation end products in cultured rat mesangial cells. Biochem Biophys Res Commun 199: 346-352, 1994
76. Buettner GR, Jurkiewicz BA: Chemistry and biochemistry of ascorbic acid. In: Handbook of Antioxidants, edited by Cadenas E, Packer L, Marcel Dekker, Inc., 1996, pp 91-115
77. Brown LAS, Jones DP: The biology of ascorbic acid. In: Handbook of Antioxidants, edited by Cadenas E, Packer L, Marcel Dekker, Inc., 1996, pp 117-154
78. Stoyanovsky DA, Goldman R, Darrow RM, Organisciak DT, Kagan VE: Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid. Curr Eye Res 14: 181-189, 1995
79. Pratico D, Lawson JA, FitzGerald GA: Cyclooxygenase dependent formation of the isoprostane, 8-epi prostaglandin F2a. J Biol Chem 270: 9800-9808, 1995
80. Cunningham JJ, Mearkle PL, Brown RG: Vitamin C: An aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr 13: 344-350, 1994
81. Hunt JV, Bottoms MA, Mitchinson MJ: Ascorbic acid oxidation: A potential cause of the elevated severity of atherosclerosis in diabetes mellitus? FEBS Lett 311: 161-164, 1992
82. 2 production) by ascorbic acid and glucose in the presence of aminotriazole: Role of transition metals and relevance to diabetes. Biochem J 303: 935-940, 1994
83. Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA: Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts: A role for lipid peroxidation. 264: 16957-16962, 1989
84. Phillips CL, Tajima S, Pinnell SR: Ascorbic acid and transforming growth factor β1 increase collagen biosynthesis via different mechanisms: Coordinate regulation of Pro α1(I) and Pro α1(III) collagens. Arch Biochem Biophys 295: 397-403, 1992
85. Pinnell SR, Murad S, Darr DP: Induction of collagen synthesis by ascorbic acid. Arch Dermatol 123: 1225-1230, 1987
86. Gessin JC, Brown LJ, Gordon JS, Berg RA: Regulation of collagen synthesis in human dermal fibroblasts in contracted collagen gels by ascorbic acid, growth factors, and inhibitors of lipid peroxidation. Exp Cell Res 206: 283-290, 1993
87. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR: Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93: 3704-3709, 1996
88. Packer L, Witt EH, Tritschler HJ: Alpha-lipoic acid as a biological antioxidant. Free Radical Biol Med 19: 227-250, 1995