Reelin binds α3β1 integrin and inhibits neuronal migration

Neuron

Volumn 27, Issue 1, 2000, Pages 33-44

  Dulabon, Lori ^a   Olson, Eric C ^b   Taglienti, Mary G ^c   Eisenhuth, Scott ^a   McGrath, Barbara ^a   Walsh, Christopher A ^b   Kreidberg, Jordan A ^c   Anton, E S ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E RECEPTOR; INTEGRIN; MUTANT PROTEIN; PROTEIN DAB1; PROTEIN REELIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR; CELL SURFACE RECEPTOR; DAB1 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; REELIN PROTEIN; SCLEROPROTEIN; SERINE PROTEINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ADHESION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; GLIA CELL; NERVE CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; CYTOLOGY; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; SERODIAGNOSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODIES, MONOCLONAL; CELL ADHESION MOLECULES, NEURONAL; CELL MOVEMENT; CELLS, CULTURED; CEREBRAL CORTEX; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA3BETA1; INTEGRINS; MICE; MICE, NEUROLOGIC MUTANTS; NERVE TISSUE PROTEINS; NEURONS; PRECIPITIN TESTS; RECEPTORS, CELL SURFACE; SERINE ENDOPEPTIDASES;

EID: 0033624279     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)00007-6     Document Type: Article

References (52)

1. β1 Integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons
2. Distinct functions of α3 and αV integrin receptors in neuronal migration and laminar organization of the cerebral cortex
3. Characterization of the integrin αVβ6 as a fibronectin-binding protein
4. Time of origin or corresponding cell classes in the cerebral cortex of normal and reeler mutant mice: An autoradiographic analysis
5. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
6. Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth
7. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
8. Detection of the Reelin breakpoint in reeler mice
9. Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody
10. Reelin is a ligand for lipoprotein receptors
11. Identification and characterization of a novel high-molecular-weight form of the integrin α3 subunit
12. Identification of integrin α3β1 as a neuronal thrombospondin receptor mediating neurite outgrowth
13. α3β1 Integrin is required for normal development of the epidermal basement membrane
14. Multiple receptor systems promote CNS neural migration
15. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia
16. Retrovirally introduced antisense integrin RNA inhibits neuroblast migration in vivo
17. Essential role of α6 integrins in cortical and retinal lamination
18. Birthdate and cell marker analysis of scrambler: A novel mutation affecting cortical development with a reeler-like phenotype
19. Nerve growth factor stimulates the accumulation of β1 integrin at the tips of filopodia in the growth cones of sympathetic neurons
20. Central nervous system neuronal migration
21. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
22. Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse
23. The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons
24. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1
25. Mouse disabled (mDab1): A Src binding protein implicated in neuronal development
26. Neuronal position in the developing brain is regulated by mouse disabled-1
27. Reelin-induced tyrosine phosphorylation of disabled 1 during neuronal positioning
28. The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids
29. Surface and cytoskeletal markers of rostrocaudal position in the mammalian nervous system
30. 2- fluctuations
31. Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase
32. Integrin cytoplasmic tyrosine motif is required for outside-in alphallbeta3 signaling and platelet function
33. Extracellular matrix and neuronal movement
34. Involvement of receptor-like protein tyrosine phosphatase zeta/RPTP beta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration
35. Regulation of Purkinje cell alignment by Reelin as revealed with CR-50 antibody
36. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
37. The reeler gene associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons
38. Synthesis and properties of the very-low-density-lipoprotein receptor and a comparison with the low-density-lipoprotein receptor
39. Obstructed neuronal migration along radial glial fibers in the neocortex of the reeler mouse: A Golgi-EM analysis
40. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries
41. Identification and distribution of proteins in isolated endosomal fractions of rat liver: Involvement in endocytosis, recycling and transcytosis
42. Kinetic and morphological evidence for endocytosis of mammalian cell integrin receptors by using an anti-fibronectin receptor beta subunit monoclonal antibody
43. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
44. Proteins of the CNR family are multiple receptors for Reelin
45. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
46. Post-translational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia
47. Interaction of cytosolic adaptor proteins with neuronal apolipoproteinE receptors and the amyloid precursor protein
48. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
49. Genetic malformations of the human cerebral cortex
50. Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse
51. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
52. Retroviral transfer of antisense integrin α6 and α8 sequences results in laminar redistribution or clonal cell death in developing brain