Potent novel nonsteroidal androgen antagonists with a phthalimide skeleton

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 11, 1997, Pages 1483-1488

  Miyachi, Hiroyuki ^a   Azuma, Akihiko ^a   Kitamoto, Takuya ^a   Hayashi, Kozue ^a   Kato, Shigeaki ^a   Koga, Masafumi ^b   Sato, Bunzo ^c   Hashimoto, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Kinki Central Hospital of Mutual Association of Public School Teachers   (Japan)

^c Nissei Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTIANDROGEN; CHLORAMPHENICOL ACETYLTRANSFERASE; FLUTAMIDE; OKADAIC ACID; PHTHALIMIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0030924642     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00249-7     Document Type: Article

References (24)

1. Tucker, H.; Crook, J. W.; Chesterson, G. J. J. Med. Chem. 1988, 31, 854.
2. Teutsch, G.; Goubet, F.; Battmann, T.; Bonfils, A.; Bouchoux, F.; Cerede, E.; Gofflo, D.; Gaillard-Kelly, M., Philibert, D. J. Steroid Biochem. Molec. Biol. 1994, 48, 111.
3. Neumann, F. Horm. Metab. Res. 1977, 9, 1.
4. Moguilewsky, M.; Bouton, M. M. J. Steroid Biochem. 1988, 31, 699.
5. Neri, R.; Peets, E.; Watnick, A. Biochem. Soc. Trans. 1979, 7, 565.
6. Raynaud, J. P.; Bonne, C.; Moguilewsky, M.; Lefebvre, F. A.; Bélanger, A.; Labrie, F. The Prostate, 1984, 5, 299.
7. Harris, M. G.; Coleman, S. G.; Faulds, D.; Chrisp, P. Drugs Aging, 1993, 3, 9.
8. Sasaki, S.; Shibata, Y.; Hashimoto, Y.; Iwasaki, S. Biol. Pharm. Bull. 1996, 18, 1228.
9. Shibata, Y.; Sasaki, K.; Hashimoto, Y.; Iwasaki, S. Chem. Pharm. Bull. 1996, 44, 156.
10. Miyachi, H.; Azuma, A.; Hioki, E.; Iwasaki, S.; Y.; Hashimoto, Y. BioMed. Chem. Lett. 1996, 6, 2293.
11. Miyachi, H.; Azuma, A.; Hashimoto, Y. Yakugaku Zasshi, 1997, 117, 91.
12. Pfizenmaier, K.; Wajant, H.; Grell, M. Cytokine & Growth Factor Rev. 1996, 7, 271.
13. Komori, A.; Yatsunami, J.; Suganuma, M.; Okabe, M.; Abe, A.; Sakai, A.; Sasaki, K.; Fujiki, H. Cancer Res. 1993, 53, 1982.
14. D'Amato, R. J.; Loughnan, M. S.; Flynn, E.; Folkman, J. Proc. Natl. Acad. Sci. USA. 1994, 91, 4082.
15. Komori, A.; Suganuma, M.; Okabe, S.; Zou, X.; Tius, M. A.; Fujiki, H. Cancer Res. 1993, 53, 3462.
16. Ebibara, K.; Masuhiro, Y.; Kitamoto, T.; Suzawa, M.; Uematsu, Y.; Yoshizawa, T.; Ono, T.; Harada, H.; Matsuda, K.; Hasegawa, T.; Masushige, S.; Kato, K. Mol. Cell. Biol. 1996, 16, 3393.
17. Kasayama, S.; Saito, H.; Kouhara, H.; Sumitani, S.; Sato, B. J. Cell. Physiol. 1993, 154, . 254.
18. Mineshita, T.; Yamaguchi, K. Cancer Res. 1966, 25: 1168.
19. Hiraoka, D.; Nakamura, N.; Nishizawa, Y.; Uchida, N.; Noguchi, S.; Matsumoto, K.; Sato, B. Cancer Res. 1987, 47: 6560.
20. Noguchi, S.; Nishizawa, Y.; Nakamura, N.; Uchida, N.; Yamaguchi, K.; Sato, B.; Kitamura, Y.; Matsumoto, K. Cancer Res., 1987, 47, 263.
21. Kato, S.; Sasaki, M.; Suzawa, S.; Masushige, S., Tora, L;, Chambon, P.; Gronemeyer, H. Mol. Cell. Biol. 1996, 15: 5858.
22. Kato, S.; Tora, L.; Yamauchi, J.; Masushige, S.; Bellard, M.; Chambon, P. Cell, 1992, 68, 731.
23. Sasaki, H.; Harada, Y.; Handa, H.; Morino, M., Suzawa, E.; Shimpo, T.; Katsumata, Y.; Masuhiro, K., Matsuda, K.; Ebihara, T.; Ono, S.; Masushige, S.; Kato, S. Biochemistry, 1996, 34, 370.
24. Miyachi, H.; Azuma, A.; Hioki, E.; Iwasaki, S.; Kobayashi, Y.; Hashimoto, Y. Biochem. Biophys. Res. Comm. 1996, 224, 430.