Carbamazepine increases extracellular serotonin concentration: Lack of antagonism by tetrodotoxin or zero Ca2+

European Journal of Pharmacology

Volumn 328, Issue 2-3, 1997, Pages 153-162

  Dailey, John W ^a   Reith, Maarten E A ^a   Yan, Qing Shan ^a   Li, Ming Ya ^a   Jobe, Phillip C ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); Ca2+; Carbamazepine; Electroshock seizure; Hippocampus; Microdialysis; Rat; Tetrodotoxin

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CALCIUM ION; CARBAMAZEPINE; METHYLCELLULOSE; MOLECUSOL; PR 320; SEROTONIN; SOLVENT; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIALYSATE; ELECTRIC SHOCK; EXOCYTOSIS; FEMALE; HIPPOCAMPUS; HISTOLOGY; INTRACEREBRAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MICRODIALYSIS; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL;

EID: 0030901848     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)83041-5     Document Type: Article

References (42)

1. Bourgeois B.F., Wad N. Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in mice. J. Pharmacol. Exp. Ther. 231:1984;411-415.
2. Browning, R.A., 1987. The role of neurotransmitters in electroshock seizure models. In: Jobe, P.C., Laird, H.E. (Eds.), Neurotransmitters and Epilepsy. Humana Press, Clifton, NJ, pp. 277-320.
3. Browning R.A., Hoffmann W.E., Simonton R.L. Changes in seizure susceptibility after intracerebral treatment with 5,7-dihydroxytryptamine: role of serotonergic neurons. Ann. NY Acad. Sci. 305:1978;437-456.
4. Buterbaugh G.G. A role for central serotonergic systems in the pattern and intensity of the convulsive response of rats to electroshock. Neuropharmacology. 16:1977;707-709.
5. Chen N.H., Reith M.E.A. Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships. J. Neurochem. 63:1994;1701-1713.
6. Dailey J.W., Reigel C.E., Mishra P.K., Jobe P.C. Neurobiology of seizure predisposition in the genetically epilepsy-prone rat. Epilepsy Res. 3:1989;3-17.
7. Dailey J.W., Mishra P.K., Ko K.H., Penny J.E., Jobe P.C. Noradrenergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Epilepsia. 32:1991;168-173.
8. Dailey J.W., Mishra P.K., Ko K.H., Penny J.E., Jobe P.C. Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Life Sci. 50:1992;319-326.
9. Dailey J.W., Yan Q.S., Mishra P.K., Burger R.L., Jobe P.C. Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 260:1992;533-540.
10. Dailey J.W., Steidley K.R., Milbrandt J., Reith M.E.A., Jobe P.C. Carbamazepine induced serotonin (5-HT) release from hippocampal slices: mechanistics studies. Pharmacologist. 39:1997;346. Abstract.
11. Faigle, J.W., Feldman, K.F., 1989. Carbamazepine biotransformation. In: Levy, R. et al. (Eds.), Antiepileptic Drugs. Raven Press, New York, NY, Vol. 3, pp. 491-504.
12. Frazer, A., Hensler, J.G., 1994. Serotonin. In: Siegel, G.J. et al. (Eds.), Basic Neurochemistry. Raven Press, New York, NY, Vol. 5, pp. 283-308.
13. Hiramatsu M., Ogawa K., Kabuto H., Mori A. Reduced uptake and release of 5-hydroxytryptamine and taurine in the cerebral cortex of epileptic El mice. Epilepsy Res. 1:1987;40-45.
14. Jobe P.C., Picchioni A.L., Chin L. Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184:1973;1-10.
15. Jobe P.C., Picchioni A.L., Chin L. Role of brain 5-hydroxytryptamine in audiogenic seizure in the rat. Life Sci. 13:1973;1-13.
16. Jobe P.C., Laird H.E., Ko K.H., Ray T., Dailey J.W. Abnormalities in monoamine levels in the central nervous system of the genetically epilepsy-prone rat. Epilepsia. 23:1982;359-366.
17. Jobe P.C., Dailey J.W., Reigel C.E. Noradrenergic and serotonergic determinants of seizure susceptibility and severity in genetically epilepsy-prone rats. Life Sci. 39:1986;775-782.
18. Jobe P.C., Lasley S.M., Burger R.L., Bettendorf A.F., Mishra P.K., Dailey J.W. Absence of an effect of aspartame on seizures induced by electroshock in epileptic and non-epileptic rats. Amino Acids. 3:1992;155-172.
19. Laird H.E., Dailey J.W., Jobe P.C. Neurotransmitter abnormalities in genetically epileptic rodents. Fed. Proc. 43:1984;2505-2509.
20. Le Quellec A., Dupin S., Genissel P., Saivin S., Marchand B., Houin G. Microdialysis probes calibration - gradient and tissue dependent changes in no net flux and reverse dialysis methods. J. Pharmacol. Toxicol. Methods. 33:1995;11-16.
21. Lindefors N., Amberg G., Ungerstedt U. Intracerebral microdialysis. I. Experimental studies of diffusion kinetics J. Pharmacol. Methods. 22:1989;141-156.
22. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
23. Pasini A., Tortorella A., Gale K. Anticonvulsant effect of intranigral fluoxetine. Brain Res. 593:1992;287-290.
24. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press Australia, Sydney, p. vii.
25. Prendiville S., Gale K. Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats. Epilepsia. 34:1993;381-384.
26. Raiteri, M., Marchi, M., Maura, G., 1984. Release of catecholamines, serotonin, and acetylcholine from isolated brain tissue. In: Lajtha, A. (Ed.), Handbook of Neurochemistry. Plenum, New York, NY, pp. 431-462.
27. Rall, T.W., Schleifer, L.S., 1990. Drugs effective in the therapy of the epilepsies. In: Gilman, A.G. et al. (Eds.), The Pharmacological Basis of Therapeutics, Pergamon Press, New York, NY, pp. 436-462.
28. Reigel C.E., Dailey J.W., Jobe P.C. The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39:1986;763-774.
29. Rogawski M.A., Porter R.J. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 42:1990;223-286.
30. Rudnick G., Wall S.C. Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters. Mol. Pharmacol. 43:1993;271-276.
31. Scheyer R.D., During M.J., Cramer J.A., Toftness B.R., Hochholzer J.M., Mattson R.H. Simultaneous hplc analysis of carbamazepine and carbamazepine epoxide in human brain microdialysate. J. Liq. Chromatogr. 17:1994;1567-1576.
32. Schuldiner S., Steiner-Mordoch S., Yelin R., Wall S.C., Rudnick G. Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Mol. Pharmacol. 44:1993;1227-1231.
33. Sharp T., Bramwell S.R., Clark D., Grahame Smith D.G. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J. Neurochem. 53:1989;234-240.
34. Sharp T., Bramwell S.R., Grahame Smith D.G. Release of endogenous 5-hydroxytryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonists. Neuroscience. 39:1990;629-637.
35. Smith J.E., Lane J.D., Shea P.A., McBride W.J. Neurochemical changes following the administration of precursors of biogenic amines. Life Sci. 21:1977;301-306.
36. Sparks D.L., Buckholtz N.S. Combined inhibition of serotonin uptake and oxidative deamination attenuates audiogenic seizures in DBA/2J mice. Pharmacol. Biochem. Behav. 23:1985;753-757.
37. Statnick M.A., Dailey J.W., Jobe P.C., Browning R.A. Abnormalities in brain serotonin uptake and steady state concentration in the genetically epilepsy-prone rat (GEPR). Soc. Neurosci. Abstr. 17:1991;171. Abstract.
38. Swinyard, E.A., 1972. Electrically induced convulsions. In: Purpura, D.P. et al. (Eds.), Experimental Models of Epilepsy - A Manual for Laboratory Worker. Raven Press, New York, NY, pp. 433-458.
39. Wada Y., Hasegawa H., Nakamura M., Yamaguchi N. Serotonergic inhibition of limbic and thalamic seizures in cats. Neuropsychobiology. 25:1992;87-90.
40. Wada Y., Nakamura M., Hasegawa H., Yamaguchi N. Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. Neurosci. Lett. 141:1992;21-24.
41. Yan Q.S., Mishra P.K., Burger R.L., Bettendorf A.F., Jobe P.C., Dailey J.W. Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 261:1992;652-659.
42. Yan Q.S., Jobe P.C., Dailey J.W. Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. Eur. J. Pharmacol. 252:1994;105-112.