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Volumn 4, Issue 3, 2005, Pages 495-501

Imatinib and gastrointestinal stromal tumors: Where do we go from here?

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DNA; ERYTHROPOIETIN; EVEROLIMUS; FLT3 LIGAND; FLUORODEOXYGLUCOSE F 18; FLUOXETINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; HYPERICUM PERFORATUM EXTRACT; IMATINIB; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; OBLIMERSEN; OROSOMUCOID; PLACEBO; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN KINASE C THETA; PROTEIN TYROSINE KINASE; RADIOISOTOPE; RIFAMPICIN; SIMVASTATIN; SUNITINIB; UNINDEXED DRUG; WARFARIN;

EID: 15944379625     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey
Times cited : (46)

References (70)
  • 1
    • 0036305274 scopus 로고    scopus 로고
    • Clinical management of gastrointestinal stromal tumors: Before and after STI-571
    • De Matteo RP, Heinrich MC, El-Rifai WM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol 2002;33:466-77.
    • (2002) Hum. Pathol. , vol.33 , pp. 466-477
    • De Matteo, R.P.1    Heinrich, M.C.2    El-Rifai, W.M.3    Demetri, G.4
  • 2
    • 0035142836 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: Definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001;438:1-12.
    • (2001) Virchows Arch. , vol.438 , pp. 1-12
    • Miettinen, M.1    Lasota, J.2
  • 3
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CDM, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002;33: 459-65.
    • (2002) Hum. Pathol. , vol.33 , pp. 459-465
    • Fletcher, C.D.M.1    Berman, J.J.2    Corless, C.3
  • 4
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence pattern and prognostic factors for survival
    • De Matteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence pattern and prognostic factors for survival. Ann Surg 2000;231:51-8.
    • (2000) Ann. Surg. , vol.231 , pp. 51-58
    • De Matteo, R.P.1    Lewis, J.J.2    Leung, D.3    Mudan, S.S.4    Woodruff, J.M.5    Brennan, M.F.6
  • 6
    • 0031947592 scopus 로고    scopus 로고
    • Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
    • Kindblom L-G, Remotti HE, Aldenborg F, Meis-Kindblom JM. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 1998;152:1259-69.
    • (1998) Am. J. Pathol. , vol.152 , pp. 1259-1269
    • Kindblom, L.-G.1    Remotti, H.E.2    Aldenborg, F.3    Meis-Kindblom, J.M.4
  • 7
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C, et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001;61:8118-21.
    • (2001) Cancer Res. , vol.61 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3
  • 8
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-KIT in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-KIT in human gastrointestinal stromal tumors. Science 1998;279:577-80.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 9
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003;299:708-10.
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 10
    • 0041971080 scopus 로고    scopus 로고
    • Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
    • Hirota S, Ohashi A, Nishida T, et al. Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors. Gastroenterology 2003;125:660-7.
    • (2003) Gastroenterology , vol.125 , pp. 660-667
    • Hirota, S.1    Ohashi, A.2    Nishida, T.3
  • 11
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996;2:561-6.
    • (1996) Nat. Med. , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 12
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000;96:925-32.
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3    Wait, C.L.4    Ott, K.A.5    Zigler, A.J.6
  • 13
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • Tuveson DA, Willis NA, Jacks T, et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene 2001;20:5054-8.
    • (2001) Oncogene , vol.20 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3
  • 14
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor ST1571 in a patient with metastatic gastrointestinal stromal tumour
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor ST1571 in a patient with metastatic gastrointestinal stromal tumour. N Engl J Med 2001;344:1052-6.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 15
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
    • van Oosterom AT, Judson I, Verweiji J, et al. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 2001;358:1421-3.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • van Oosterom, A.T.1    Judson, I.2    Verweiji, J.3
  • 16
    • 0036769721 scopus 로고    scopus 로고
    • Update of a phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: A report of the EORTC Soft Tissue and Bone Sarcoma Group
    • van Oosterom AT, Judson IR, Verweij J, et al. Update of a phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2002;38 Suppl 5:S83-7.
    • (2002) Eur. J. Cancer , vol.38 , Issue.SUPPL. 5
    • van Oosterom, A.T.1    Judson, I.R.2    Verweij, J.3
  • 17
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-80.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 18
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
    • Verweij J, van Oosterom A, Blay J-Y, et al. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 2003; 39:2006-11.
    • (2003) Eur. J. Cancer , vol.39 , pp. 2006-2011
    • Verweij, J.1    van Oosterom, A.2    Blay, J.-Y.3
  • 19
    • 4544227216 scopus 로고    scopus 로고
    • Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results
    • (abstr 9005)
    • Rankin C, Von Mehren M, Blanke C, et al. Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results. Proc Am Soc Clin Oncol 2004;23:815. (abstr 9005).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 815
    • Rankin, C.1    Von Mehren, M.2    Blanke, C.3
  • 20
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004;364:1127-34.
    • (2004) Lancet , vol.364 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 21
    • 0036795899 scopus 로고    scopus 로고
    • Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
    • Dagher R, Cohen M, Williams G, et al. Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res 2002;8:3034-8.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3034-3038
    • Dagher, R.1    Cohen, M.2    Williams, G.3
  • 22
    • 4544351070 scopus 로고    scopus 로고
    • Continuous vs intermittent imatinib treatment in advanced GIST after one year: A prospective randomized phase III trial of the French Sarcoma Group
    • (abstr 9006)
    • Blay J-Y, Berthaud P, Perol D, et al. Continuous vs intermittent imatinib treatment in advanced GIST after one year: a prospective randomized phase III trial of the French Sarcoma Group. Proc Am Soc Clin Oncol 2004;23:815. (abstr 9006).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 815
    • Blay, J.-Y.1    Berthaud, P.2    Perol, D.3
  • 23
    • 10744224969 scopus 로고    scopus 로고
    • + gastrointestinal stromal tumors treated with imatinib mesylate?
    • + gastrointestinal stromal tumors treated with imatinib mesylate? Am J Surg 2003;186:665-9.
    • (2003) Am. J. Surg. , vol.186 , pp. 665-669
    • Scaife, C.L.1    Hunt, K.K.2    Patel, S.R.3
  • 24
    • 18144391627 scopus 로고    scopus 로고
    • Safety and efficacy of percutaneous radio-frequency ablation in patients with metastatic gastrointestinal stromal tumor with clonal evolution of lesions refractory to imatinib mesylate
    • Dileo P, Randhawa R, Vansonnenberg E, et al. Safety and efficacy of percutaneous radio-frequency ablation in patients with metastatic gastrointestinal stromal tumor with clonal evolution of lesions refractory to imatinib mesylate. Proc Am Soc Clin Oncol 2004;23:9024.
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 9024
    • Dileo, P.1    Randhawa, R.2    Vansonnenberg, E.3
  • 25
    • 51349102200 scopus 로고    scopus 로고
    • Erythropoietin for anemia treatment of patients with GIST receiving imatinib
    • (abstr 9046)
    • Duffaud F, Lecesne A, Ray-Coquard I, et al. Erythropoietin for anemia treatment of patients with GIST receiving imatinib. Proc Am Soc Clin Oncol 2004;23:825. (abstr 9046).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 825
    • Duffaud, F.1    Lecesne, A.2    Ray-Coquard, I.3
  • 26
    • 0242668791 scopus 로고    scopus 로고
    • G-CSF for imatinib-induced neutropenia
    • Heim D, Ebnöther M, Meyer-Monard S, et al. G-CSF for imatinib-induced neutropenia. Leukemia 2003;17:805-7.
    • (2003) Leukemia , vol.17 , pp. 805-807
    • Heim, D.1    Ebnöther, M.2    Meyer-Monard, S.3
  • 27
    • 15944376032 scopus 로고    scopus 로고
    • Gleevec (imatinib mesylate) prescribing information
    • Novartis Pharmaceutical Corporation Novartis Pharmaceuticals Corporation, NJ, USA, 2004. Available from: Accessed February
    • Novartis Pharmaceutical Corporation. Gleevec (imatinib mesylate) prescribing information. Novartis Pharmaceuticals Corporation, NJ, USA, 2004. Available from: http://www.pharma.us.novartis.com/product/pi/pdf/gleevec_tabs.pdf. Accessed February 2005.
    • (2005)
  • 28
    • 0346104877 scopus 로고    scopus 로고
    • Role of imatinib mesylate (Gleevec/Glivec) in gastrointestinal stromal tumors
    • de Jong FA, Verweij J. Role of imatinib mesylate (Gleevec/Glivec) in gastrointestinal stromal tumors. Expert Rev Anticancer Ther 2003;3: 757-66.
    • (2003) Expert Rev. Anticancer Ther. , vol.3 , pp. 757-766
    • de Jong, F.A.1    Verweij, J.2
  • 29
    • 4644287353 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects
    • Dutreix C, Peng B, Mehring G, et al. Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects. Cancer Chemother Pharmacol 2004;54:290-4.
    • (2004) Cancer Chemother. Pharmacol. , vol.54 , pp. 290-294
    • Dutreix, C.1    Peng, B.2    Mehring, G.3
  • 31
    • 0442313672 scopus 로고    scopus 로고
    • Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects
    • Bolton AE, Peng B, Hubert M, et al. Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects. Cancer Chemother Pharmacol 2004;53:102-6.
    • (2004) Cancer Chemother. Pharmacol. , vol.53 , pp. 102-106
    • Bolton, A.E.1    Peng, B.2    Hubert, M.3
  • 33
    • 10744231436 scopus 로고    scopus 로고
    • Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia
    • O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 2003;89:1855-9.
    • (2003) Br. J. Cancer , vol.89 , pp. 1855-1859
    • O'Brien, S.G.1    Meinhardt, P.2    Bond, E.3
  • 34
    • 0348101421 scopus 로고    scopus 로고
    • P-5331: A phase I pharmacokinetic study of STI571 in patients with advanced malignancies and varying degrees of liver dysfunction
    • (abstr 502)
    • Ramanathan RK, Remick SC, Mulkerin D, et al. P-5331: a phase I pharmacokinetic study of STI571 in patients with advanced malignancies and varying degrees of liver dysfunction. Proc Am Soc Clin Oncol 2003;22:126. (abstr 502).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 126
    • Ramanathan, R.K.1    Remick, S.C.2    Mulkerin, D.3
  • 35
    • 0348101421 scopus 로고    scopus 로고
    • P-5340: A phase I pharmacokinetic study of STI571 in patients with advanced malignancies and varying degrees of renal dysfunction
    • (abstr 503)
    • Remick SC, Ramanathan RK, Mulkerin D, et al. P-5340: a phase I pharmacokinetic study of STI571 in patients with advanced malignancies and varying degrees of renal dysfunction. Proc Am Soc Clin Oncol 2003;22:126. (abstr 503).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 126
    • Remick, S.C.1    Ramanathan, R.K.2    Mulkerin, D.3
  • 36
    • 15944373352 scopus 로고    scopus 로고
    • Population pharmacokinetics (PK) analysis and PK-pharmacodynamic (PD) correlations in phase I/II trial of imatinib in gastrointestinal stromal tumours (GIST) conducted by the European Organisation for Research and Treatment Soft Tissue and Bone Sarcoma Group
    • Epub Dec 9
    • Judson IR, Donato Di Paola E, Verweij J, et al. Population pharmacokinetics (PK) analysis and PK-pharmacodynamic (PD) correlations in phase I/II trial of imatinib in gastrointestinal stromal tumours (GIST) conducted by the European Organisation for Research and Treatment Soft Tissue and Bone Sarcoma Group. Cancer Chemother Pharmacol Epub 2004 Dec 9.
    • (2004) Cancer Chemother. Pharmacol.
    • Judson, I.R.1    Donato Di Paola, E.2    Verweij, J.3
  • 37
    • 15944417295 scopus 로고    scopus 로고
    • Inflammatory response affects the pharmacokinetics and pharmacodynamics of imatinib and CGP 74588 in patients with advanced gastro-intestinal-sarcoma (GIST)
    • (abstr 2070)
    • Delbaldo C, Chatelut E, Rè M, et al. Inflammatory response affects the pharmacokinetics and pharmacodynamics of imatinib and CGP 74588 in patients with advanced gastro-intestinal-sarcoma (GIST). Proc Am Soc Clin Oncol 2004;23:144. (abstr 2070).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 144
    • Delbaldo, C.1    Chatelut, E.2    Rè, M.3
  • 38
    • 0242684607 scopus 로고    scopus 로고
    • Inflammatory response: An unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy
    • Slaviero KA, Clarke SJ, Rivory LP. Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy. Lancet Oncol 2003;4: 224-32.
    • (2003) Lancet Oncol. , vol.4 , pp. 224-232
    • Slaviero, K.A.1    Clarke, S.J.2    Rivory, L.P.3
  • 39
    • 2542520755 scopus 로고    scopus 로고
    • Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    • Duensing A, Medeiros F, McConarty B, et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 2004;23:3999-4006.
    • (2004) Oncogene , vol.23 , pp. 3999-4006
    • Duensing, A.1    Medeiros, F.2    McConarty, B.3
  • 40
    • 0036092268 scopus 로고    scopus 로고
    • KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size
    • Corless CL, McGreevey L, Haley A, Town A, Heinrich MC. KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size. Am J Pathol 2002;160:1567-72.
    • (2002) Am. J. Pathol. , vol.160 , pp. 1567-1572
    • Corless, C.L.1    McGreevey, L.2    Haley, A.3    Town, A.4    Heinrich, M.C.5
  • 41
    • 0031848146 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
    • Nishida T, Hirota S, Taniguchi M, et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet 1998;19:323-4.
    • (1998) Nat. Genet. , vol.19 , pp. 323-324
    • Nishida, T.1    Hirota, S.2    Taniguchi, M.3
  • 42
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002;33:484-95.
    • (2002) Hum. Pathol. , vol.33 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3    Fletcher, J.A.4
  • 43
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003;21:4342-9.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 45
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter M, Dumez H, Judson I, et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2004;40:689-95.
    • (2004) Eur. J. Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 46
    • 2542462086 scopus 로고    scopus 로고
    • Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site
    • Antonescu CR, Viale A, Sarran L, et al. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site. Clin Cancer Res 2004;15:3282-90.
    • (2004) Clin. Cancer Res. , vol.15 , pp. 3282-3290
    • Antonescu, C.R.1    Viale, A.2    Sarran, L.3
  • 47
    • 0347256705 scopus 로고    scopus 로고
    • Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors
    • Frolov A, Chahwan S, Ochs M, et al. Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors. Mol Cancer Ther 2003;2:699-709.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 699-709
    • Frolov, A.1    Chahwan, S.2    Ochs, M.3
  • 48
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol 2004;28:889-94.
    • (2004) Am. J. Surg. Pathol. , vol.28 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 49
    • 0344837699 scopus 로고    scopus 로고
    • Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT
    • Bauer S, Corless CL, Heinrich MC, et al. Response to imatinib mesylate of a gastrointestinal stromal tumor with very low expression of KIT. Cancer Chemother Pharmacol 2003;51:261-5.
    • (2003) Cancer Chemother. Pharmacol. , vol.51 , pp. 261-265
    • Bauer, S.1    Corless, C.L.2    Heinrich, M.C.3
  • 50
    • 0242691165 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in advanced gastrointestinal tumor
    • (abstr 3275)
    • Fletcher JA, Corless CL, Dimitrijevic S, et al. Mechanisms of resistance to imatinib mesylate in advanced gastrointestinal tumor. Proc Am Soc Clin Oncol 2003;22:815. (abstr 3275).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 815
    • Fletcher, J.A.1    Corless, C.L.2    Dimitrijevic, S.3
  • 51
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, Pirmohamed M. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004;104:3739-45.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3    Pirmohamed, M.4
  • 52
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • Burger H, Van Tol H, Boersma AW, et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 2004;104:2940-2.
    • (2004) Blood , vol.104 , pp. 2940-4942
    • Burger, H.1    Van Tol, H.2    Boersma, A.W.3
  • 54
    • 9144233483 scopus 로고    scopus 로고
    • Inhibitory effect of imatinib on normal progenitor cells in vitro
    • Bartolovic K, Balabanov S, Hartmann U, et al. Inhibitory effect of imatinib on normal progenitor cells in vitro. Blood 2004;103:523-9.
    • (2004) Blood , vol.103 , pp. 523-529
    • Bartolovic, K.1    Balabanov, S.2    Hartmann, U.3
  • 55
    • 0037295225 scopus 로고    scopus 로고
    • Malignant gastrointestinal stromal tumor: Distribution, imaging features, and pattern of metastatic spread
    • Burkill GJ, Badran M, Al-Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology 2003;226:527-32.
    • (2003) Radiology , vol.226 , pp. 527-532
    • Burkill, G.J.1    Badran, M.2    Al-Muderis, O.3
  • 56
  • 57
    • 15944391505 scopus 로고    scopus 로고
    • Clonal evolution of resistance to imatinib in patients with gastrointestinal stromal tumor (GIST): Molecular and radiological evaluation of new lesions
    • (abstr 3010)
    • Desai J, Shankar S, Heinrich MC, et al. Clonal evolution of resistance to imatinib in patients with gastrointestinal stromal tumor (GIST): molecular and radiological evaluation of new lesions. Proc Am Soc Clin Oncol 2004;23:197. (abstr 3010).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 197
    • Desai, J.1    Shankar, S.2    Heinrich, M.C.3
  • 58
    • 1542682511 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring
    • Knopp MV, von Tengg-Kobligk H, Choyke PL. Functional magnetic resonance imaging in oncology for diagnosis and therapy monitoring. Mol Cancer Ther 2003;2:419-26.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 419-426
    • Knopp, M.V.1    von Tengg-Kobligk, H.2    Choyke, P.L.3
  • 59
    • 0344438131 scopus 로고    scopus 로고
    • Molecular imaging and cancer
    • Blasberg RG. Molecular imaging and cancer. Mol Cancer Ther 2003;2:335-43.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 335-343
    • Blasberg, R.G.1
  • 60
    • 15944403348 scopus 로고    scopus 로고
    • Doppler-ultrasonography with perfusion software and contrast medium injection as an early evaluation tool of gastro intestinal stromal tumor (GIST) treated by imatinib: Results of a prospective study
    • (abstr 9048)
    • Lassau N, Lamuraglia M, Leclère J, et al. Doppler-ultrasonography with perfusion software and contrast medium injection as an early evaluation tool of gastro intestinal stromal tumor (GIST) treated by imatinib: results of a prospective study. Proc Am Soc Clin Oncol 2004;23:826. (abstr 9048).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 826
    • Lassau, N.1    Lamuraglia, M.2    Leclère, J.3
  • 61
    • 15944393684 scopus 로고    scopus 로고
    • Effect of angio-sonography with a second generation contrast agent to assess tumor response to imatinib treatment in patients with advanced gastrointestinal stromal tumor (GIST)
    • (abstr 4216)
    • De Giorgi U, Aliberti C, Benea G, Conti M, Marangolo M. Effect of angio-sonography with a second generation contrast agent to assess tumor response to imatinib treatment in patients with advanced gastrointestinal stromal tumor (GIST). Proc Am Soc Clin Oncol 2004;23:366. (abstr 4216).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 366
    • De Giorgi, U.1    Aliberti, C.2    Benea, G.3    Conti, M.4    Marangolo, M.5
  • 62
    • 7644242712 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles
    • Subramanian S, West RB, Corless CL, et al. Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene 2004;23:7780-90.
    • (2004) Oncogene , vol.23 , pp. 7780-7790
    • Subramanian, S.1    West, R.B.2    Corless, C.L.3
  • 63
    • 3042594995 scopus 로고    scopus 로고
    • The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status
    • West RB, Corless CL, Chen X, et al. The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol 2004;165:107-13.
    • (2004) Am. J. Pathol. , vol.165 , pp. 107-113
    • West, R.B.1    Corless, C.L.2    Chen, X.3
  • 64
    • 3042538269 scopus 로고    scopus 로고
    • Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias
    • Blay P, Astudillo A, Buesa JM, et al. Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. Clin Cancer Res 2004;10:4089-95.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4089-4095
    • Blay, P.1    Astudillo, A.2    Buesa, J.M.3
  • 65
    • 4043134677 scopus 로고    scopus 로고
    • Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
    • Borg C, Terme M, Taieb J, et al. Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest 2004;114:379-88.
    • (2004) J. Clin. Invest. , vol.114 , pp. 379-388
    • Borg, C.1    Terme, M.2    Taieb, J.3
  • 66
    • 1642494654 scopus 로고    scopus 로고
    • Absolute bioavailability of imatinib orally versus intravenous infusion
    • Peng B, Dutreix C, Mehring G, et al. Absolute bioavailability of imatinib orally versus intravenous infusion. J Clin Pharmacol 2004;44: 158-62.
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 158-162
    • Peng, B.1    Dutreix, C.2    Mehring, G.3
  • 68
    • 4644222221 scopus 로고    scopus 로고
    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST)
    • (abstr 3001)
    • Demetri GO, Desai J, Fletcher JA, et al. SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST). Proc Am Soc Clin Oncol 2004;23:195. (abstr 3001).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 195
    • Demetri, G.O.1    Desai, J.2    Fletcher, J.A.3
  • 69
    • 8344253460 scopus 로고    scopus 로고
    • Combination signal transduction inhibition: A phase I/II trial of the oral mTOR-inhibitor everolimus (RAD001) and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM
    • (abstr 3002)
    • Van Oosterom AT, Dumez H, Desai J, et al. Combination signal transduction inhibition: A phase I/II trial of the oral mTOR-inhibitor everolimus (RAD001) and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM. Proc Am Soc Clin Oncol 2004;23:195. (abstr 3002).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 195
    • Van Oosterom, A.T.1    Dumez, H.2    Desai, J.3
  • 70
    • 84889960997 scopus 로고    scopus 로고
    • National Cancer Institute Clinical Trials
    • [cited 2005 Feb]. Available from:
    • National Cancer Institute Clinical Trials. [cited 2005 Feb]. Available from: http://cancer.gov/search/ ResultsClinicalTrials.aspx?protocol-searchid=1428474


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