-
1
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell. 2002;108:153-164.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
2
-
-
0033179760
-
bcl-2 family members and the mitochondria in apoptosis
-
Gross A, McDonnell JM, Korsmeyer SJ. bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 1999;13:1899-1911.
-
(1999)
Genes Dev
, vol.13
, pp. 1899-1911
-
-
Gross, A.1
McDonnell, J.M.2
Korsmeyer, S.J.3
-
3
-
-
0032575688
-
The bcl-2 protein family: Arbiters of cell survival
-
Adams JM, Cory S. The bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-1326.
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
4
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995;80:293-299.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
5
-
-
0842278331
-
Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004;303:1010-1014.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
-
6
-
-
0027166048
-
bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
-
Oltvai ZN, Milliman CL, Korsmeyer SJ. bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 1993;74:609-619.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
7
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, et al. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. 2002;2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
-
8
-
-
0036175062
-
Emerging pathways in colorectal-cancer development
-
Haydon AM, Jass JR. Emerging pathways in colorectal-cancer development. Lancet Oncol. 2002;3:83-88.
-
(2002)
Lancet Oncol
, vol.3
, pp. 83-88
-
-
Haydon, A.M.1
Jass, J.R.2
-
9
-
-
0036569940
-
Mutations at coding repeat sequences in mismatch repair-deficient human cancers: Toward a new concept of target genes for instability
-
Duval A, Hamelin R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res. 2002;62:2447-2454.
-
(2002)
Cancer Res
, vol.62
, pp. 2447-2454
-
-
Duval, A.1
Hamelin, R.2
-
10
-
-
0031018674
-
Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype
-
Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype. Science. 1997;275:967-969.
-
(1997)
Science
, vol.275
, pp. 967-969
-
-
Rampino, N.1
Yamamoto, H.2
Ionov, Y.3
-
11
-
-
0031038137
-
bax suppresses tumorigenesis and stimulates apoptosis in vivo
-
Yin C, Knudson CM, Korsmeyer SJ, et al. bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature. 1997;385:637-640.
-
(1997)
Nature
, vol.385
, pp. 637-640
-
-
Yin, C.1
Knudson, C.M.2
Korsmeyer, S.J.3
-
12
-
-
0037096737
-
Critical requirement of bax for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells
-
Theodorakis P, Lomonosova E, Chinnadurai G. Critical requirement of bax for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells. Cancer Res. 2002;62:3373-3376.
-
(2002)
Cancer Res
, vol.62
, pp. 3373-3376
-
-
Theodorakis, P.1
Lomonosova, E.2
Chinnadurai, G.3
-
13
-
-
0036467867
-
bax expression decreases significantly from primary tumor to metastasis in colorectal cancer
-
Jansson A, Sun XF. bax expression decreases significantly from primary tumor to metastasis in colorectal cancer. J Clin Oncol. 2002;20:811-816.
-
(2002)
J Clin Oncol
, vol.20
, pp. 811-816
-
-
Jansson, A.1
Sun, X.F.2
-
14
-
-
0031784625
-
Apoptosis and expression of bax, bcl-x, and bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
-
De Angelis PM, Stokke T, Thorstensen L, et al. Apoptosis and expression of bax, bcl-x, and bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype. Mol Pathol. 1998;51:254-261.
-
(1998)
Mol Pathol
, vol.51
, pp. 254-261
-
-
De Angelis, P.M.1
Stokke, T.2
Thorstensen, L.3
-
15
-
-
0032534069
-
A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
-
Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248-5257.
-
(1998)
Cancer Res
, vol.58
, pp. 5248-5257
-
-
Boland, C.R.1
Thibodeau, S.N.2
Hamilton, S.R.3
-
16
-
-
0025848680
-
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
-
Vasen HF, Mecklin JP, Khan PM, et al. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum. 1991;34:424-425.
-
(1991)
Dis Colon Rectum
, vol.34
, pp. 424-425
-
-
Vasen, H.F.1
Mecklin, J.P.2
Khan, P.M.3
-
17
-
-
0141731323
-
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
-
Fallik D, Borrini F, Boige V, et al. Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res. 2003;63:5738-5744.
-
(2003)
Cancer Res
, vol.63
, pp. 5738-5744
-
-
Fallik, D.1
Borrini, F.2
Boige, V.3
-
18
-
-
0029045784
-
Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
-
Krajewski S, Blomqvist C, Franssila K, et al. Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res. 1995;55:4471-4478.
-
(1995)
Cancer Res
, vol.55
, pp. 4471-4478
-
-
Krajewski, S.1
Blomqvist, C.2
Franssila, K.3
-
19
-
-
0344348993
-
Analysis of the p53/bax pathway in colorectal cancer: Low bax is a negative prognostic factor in patients with resected liver metastases
-
Sturm I, Kohne CH, Wolff G, et al. Analysis of the p53/bax pathway in colorectal cancer: low bax is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol. 1999;17:1364-1374.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1364-1374
-
-
Sturm, I.1
Kohne, C.H.2
Wolff, G.3
-
20
-
-
0029945789
-
Elevated expression of bcl-X and reduced bak in primary colorectal adenocarcinomas
-
Krajewska M, Moss SF, Krajewski S, et al. Elevated expression of bcl-X and reduced bak in primary colorectal adenocarcinomas. Cancer Res. 1996;56:2422-2427.
-
(1996)
Cancer Res
, vol.56
, pp. 2422-2427
-
-
Krajewska, M.1
Moss, S.F.2
Krajewski, S.3
-
21
-
-
0036183810
-
Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer
-
Gervaz P, Cerottini JP, Bouzourene H, et al. Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. Surgery. 2002;131:190-197.
-
(2002)
Surgery
, vol.131
, pp. 190-197
-
-
Gervaz, P.1
Cerottini, J.P.2
Bouzourene, H.3
-
22
-
-
0035070638
-
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer
-
Samowitz WS, Holden JA, Curtin K, et al. Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer. Am J Pathol. 2001;158:1517-1524.
-
(2001)
Am J Pathol
, vol.158
, pp. 1517-1524
-
-
Samowitz, W.S.1
Holden, J.A.2
Curtin, K.3
-
23
-
-
0034892805
-
Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer
-
Michael-Robinson JM, Reid LE, Purdie DM, et al. Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. Clin Cancer Res. 2001;7:2347-2356.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2347-2356
-
-
Michael-Robinson, J.M.1
Reid, L.E.2
Purdie, D.M.3
-
24
-
-
0032032682
-
Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer
-
Yamamoto H, Sawai H, Weber TK, et al. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Cancer Res. 1998;58:997-1003.
-
(1998)
Cancer Res
, vol.58
, pp. 997-1003
-
-
Yamamoto, H.1
Sawai, H.2
Weber, T.K.3
-
25
-
-
0031727071
-
Microsatellite instability and frameshift mutations in the bax gene in hereditary nonpolyposis colorectal carcinoma
-
Sakao Y, Noro M, Sekine S, et al. Microsatellite instability and frameshift mutations in the bax gene in hereditary nonpolyposis colorectal carcinoma. Jpn J Cancer Res. 1998;89:1020-1027.
-
(1998)
Jpn J Cancer Res
, vol.89
, pp. 1020-1027
-
-
Sakao, Y.1
Noro, M.2
Sekine, S.3
-
26
-
-
0031940209
-
Proapoptotic gene bax is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas
-
Yagi OK, Akiyama Y, Nomizu T, et al. Proapoptotic gene bax is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology. 1998;114:268-274.
-
(1998)
Gastroenterology
, vol.114
, pp. 268-274
-
-
Yagi, O.K.1
Akiyama, Y.2
Nomizu, T.3
-
27
-
-
0031895510
-
The bax gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium
-
Ouyang H, Furukawa T, Abe T, et al. The bax gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium. Clin Cancer Res. 1998;4:1071-1074.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1071-1074
-
-
Ouyang, H.1
Furukawa, T.2
Abe, T.3
-
28
-
-
0033946516
-
Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGFbetaRII, bax, hMSH3, hMSH6, IGFIIR and blm genes
-
Calin GA, Gafa R, Tibiletti MG, et al. Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: a study of the TGFbetaRII, bax, hMSH3, hMSH6, IGFIIR and blm genes. Int J Cancer. 2000;89:230-235.
-
(2000)
Int J Cancer
, vol.89
, pp. 230-235
-
-
Calin, G.A.1
Gafa, R.2
Tibiletti, M.G.3
-
29
-
-
0032422475
-
Apoptosis inhibiting factor bcl-xL might be the crucial member of the bcl-2 gene family in colorectal cancer
-
Maurer CA, Friess H, Buhler SS, et al. Apoptosis inhibiting factor bcl-xL might be the crucial member of the bcl-2 gene family in colorectal cancer. Dig Dis Sci. 1998;43:2641-2648.
-
(1998)
Dig Dis Sci
, vol.43
, pp. 2641-2648
-
-
Maurer, C.A.1
Friess, H.2
Buhler, S.S.3
-
30
-
-
0035793799
-
Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer
-
Paradiso A, Simone G, Lena MD, et al. Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer. Br J Cancer. 2001;84:651-658.
-
(2001)
Br J Cancer
, vol.84
, pp. 651-658
-
-
Paradiso, A.1
Simone, G.2
Lena, M.D.3
-
31
-
-
0034718591
-
Mutational inactivation of the proapoptotic gene bax confers selective advantage during tumor clonal evolution
-
Ionov Y, Yamamoto H, Krajewski S, et al. Mutational inactivation of the proapoptotic gene bax confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci U S A. 2000;97:10872-10877.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10872-10877
-
-
Ionov, Y.1
Yamamoto, H.2
Krajewski, S.3
-
32
-
-
0033602406
-
Role of bax mutations in mismatch repair-deficient colorectal carcinogenesis
-
Abdel-Rahman WM, Georgiades IB, Curtis LJ, et al. Role of bax mutations in mismatch repair-deficient colorectal carcinogenesis. Oncogene. 1999;18:2139-2142.
-
(1999)
Oncogene
, vol.18
, pp. 2139-2142
-
-
Abdel-Rahman, W.M.1
Georgiades, I.B.2
Curtis, L.J.3
-
33
-
-
0033848832
-
Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity
-
Barnetson R, Jass J, Tse R, et al. Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. Genes Chromosomes Cancer. 2000;29:130-136.
-
(2000)
Genes Chromosomes Cancer
, vol.29
, pp. 130-136
-
-
Barnetson, R.1
Jass, J.2
Tse, R.3
-
34
-
-
0032532553
-
Reciprocal relationship between the tumor suppressors p53 and bax in primary colorectal cancers
-
Simms LA, Radford-Smith G, Biden KG, et al. Reciprocal relationship between the tumor suppressors p53 and bax in primary colorectal cancers. Oncogene. 1998;17:2003-2008.
-
(1998)
Oncogene
, vol.17
, pp. 2003-2008
-
-
Simms, L.A.1
Radford-Smith, G.2
Biden, K.G.3
|