Promiscuous liberation of MHC-class I-binding peptides from the C termini of membrane and soluble proteins in the secretory pathway

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1337-1344

  Snyder, Heidi Link ^a   Bačík, Igor ^a   Yewdell, Jonathan W ^a   Bohrens, Timothy W ^b   Bennink, Jack R ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Antigen processing; Endoplasmic reticulum; MHC class I; Peptide; Protease

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENDOPLASMIC RETICULUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; T LYMPHOCYTE; VACCINIA VIRUS; VIRUS RECOMBINANT;

EID: 15644375065     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Heemels, M.-T. and Ploegh, H., Generation, translocation, and presentation of MHC class-I restricted peptides. Annu. Rev. Biochem. 1995. 64: 463-491.
2. York, I. and Rock, K. L., Antigen processing and presentation by the class I major histocompatibility complex. Annu. Rev. Immunol. 1996. 14: 369-396.
3. Lehner, P. J. and Cresswell, P., Processing and delivery of peptides presented by MHC class I molecules. Curr. Opin. Immunol. 1996. 8: 59-67.
4. Rammensee, H.-G., Friede, T. and Stevanovic, S., MHC ligands and peptide motifs: first listing, Immunogenetics 1995. 41: 178-228.
5. Engelhard, V. H., Structures of peptides associated with class I and class II MHC molecules. Annu. Rev. Immunol. 1994. 12: 181-207.
6. Engelhard, V. H., Structure of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 1994. 6: 13-23.
7. Ossendorp, F., Eggers, M., Neisig, A., Ruppert, T., Groettrup, M., Sijts, A., Mengede, E., Kloetzel, P.-M., Neefjes, J., Koszinowski, U. and Melief, C., A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. Immunity 1996. 5: 115-124.
8. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D. and Goldberg, A. L., Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994. 78: 761-771.
9. Ostrowska, H., Wojcik, C., Omura, S. and Woroowski, K., Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem. Biophys. Res. Commun. 1997. 234: 729-732.
10. Vinitsky, A., Antón, L. C., Snyder, H. L., Orlowski, M., Bennink, J. R. and Yewdell, J. W., The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: Involvement of nonproteasomal cytosolic proteases in antigen processing? J. Immunol. 1997. 159: 554-564.
11. Yellen-Shaw, A. J. and Eisenlohr, L. C., Regulation of class-I restricted epitope processing by local or distal flanking sequence. J. Immunol. 1997. 158: 1727-1733.
12. Cerundolo, V., Benham, V., Braud, V., Mukherjee, S., Gould, K., Macino, B., Neefjes, J. and Townsend, A., The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells. Eur. J. Immunol. 1997. 27: 336-341.
13. Anderson, K., Cresswell, P., Gammon, M., Hermes, J., Williamson, A. and Zweerink, H., Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis. J. Exp. Med. 1991. 174: 489-492.
14. Bačík, I., Cox, J. H., Anderson, R., Yewdell, J. W. and Bennink, J. R., TAP-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino but not carboxy terminus of the peptide. J. Immunol. 1994. 152: 381-387.
15. Deng, Y., Yewdell, J. W., Eisenlohr, L. C. and Bennink, J. R., MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J. Immunol. 1997. 158: 1507-1515.
16. Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R. and Germain, R. N., Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 1997. 6: 715-726.
17. Siliciano, R. F. and Soloski, M. J., MHC class I-restricted processing of transmenbrane proteins Mechanism and biological significance. J. Immunol. 1995. 155: 1-5.
18. Townsend, A. R. M., Bastin, J., Gould, K. and Brownlee, G. G., Cytotoxic T lymphocytes recognize influenza hemagglutinin that lacks a signal sequence. Nature 1986. 324: 575-577.
19. Skipper, J. C. A., Hendrickson, R. C., Gulden, P. H., Brichard, V., Van Pel, A., Chen, Y., Shabanowitz, J., Wolfel, T., Slingluff, C. L., Boon, T., Hunt, D. F. and Engelhard, V. H., An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. J. Exp. Med. 1996. 183: 527-534.
20. Bačík, I., Link-Snyder, H., Antón, L. C., Russ, G., Chen, W., Bennink, J. R., Urge, L., Otvos, L., Dudkowska, B., Eisenlohr, L. and Yewdell, J. W., Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway-transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to the cytosol. J. Exp. Med. 1997. 186: 479-487.
21. Elliott, T, Willis, A., Cerundolo, V. and Townsend, A., Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J. Exp. Med. 1995. 181: 1481-1491.
22. Snyder, H. L., Yewdell, J. W. and Bennink, J. R., Trimming of antigenic peptides in an early secretory compartment. J. Exp. Med. 1994. 180: 2389-2394.
23. Snyder, H. L., Bačík, I., Bennink, J. R., Kearns, G., Behrens, T. W., Bachi, T., Orlowski, M. and Yewdell, J. W., Two novel routes of transporter associated with antigen processing (TAP)-independent major histocompatibility complex class I antigen processing. J. Exp. Med. 1997. 186: 1087-1098.
24. Cerundolo, V., Kelly, A., Elliot, T., Trowsdale, J. and Townsend, A., Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. Eur. J. Immunol. 1995. 25: 554-562.
25. Ludin, C., Hofstetter, H., Sarfati, M., Levy, C. A., Suter, U., Alaimo, D., Kilchherr, E., Frost, H. and Delespesse, G., Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J. 1987. 6: 109-114.
26. Eisenlohr, L. C., Yewdell, J. W. and Bennink, J. R., Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes. J. Exp. Med. 1992. 175: 481-487.
27. Eisenlohr, L. C., Bacik, I., Bennink, J. R., Bernstein, K. and Yewdell, J. W., Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes. Cell 1992. 71: 963-972.
28. Falk, K., Rötzschke, O. and Rammensee, H.-G., Cellular peptide composition governed by major histocompatibility complex class I molecules. Nature 1990. 348: 248-251.
29. Sijts, A. J. A. M. and Pamer, E. G., Enchanced intracellular dissociation of major histocompatibility complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. J. Exp. Med. 1997. 185: 1403-1411.
30. + T cells. Nature 1993. 364: 158-161.
31. + CTL. J. Immunol. 1995. 154: 6140-6156.
32. Powis, S. J., Young, L. L., Joly, E., Barker, P. J., Richardson, L., Brandt, R. P., Melief, C. J., Howard, J. C. and Butcher, G. W., The rat cim effect: TAP alleledependent changes in a class I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER. Immunity 1996. 4: 159-165.
33. Salter, R. D. and Cresswell, P., Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J. 1986. 5: 943-949.
34. Yewdell, J. W., Bennink, J. R., Smith, G. L. and Moss, B., Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 1985. 82: 1785-1789.
35. Yewdell, J. W., Esquivel, F., Arnold, D., Spies, T., Eisenlohr, L. C. and Bennink, J. R., Presentation of numerous viral peptides to mouse MHC class I restricted T lymphocytes is mediated by the human MHC encoded transporter or by a hubrid mouse-human transporter. J. Exp. Med. 1993. 177: 1785-1790.
36. Russ, G., Esquivel, F., Cresswell, P., Spies, T., Yewdell, J. W. and Bennink, J. R., Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters Tap1 and Tap2 expressed by recombinant vaccinia viruses. J. Biol. Chem. 1995. 270: 21312-21318.
37. Chakrabarti, S., Brechung, K. and Moss, B., Vaccinia virus expression vector: coexpression of β-galactosidase provides visual screening of recombinant virus plaques. Mol. Cell. Biol. 1985. 5: 3403-3409.