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Volumn 7, Issue 1, 2005, Pages 34-39

Pleiotropic effects of statins: Moving beyond cholesterol control

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; COMPACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; MEVINOLIN; NITRIC OXIDE; PRAVASTATIN; PROTEIN P21; TISSUE INHIBITOR OF METALLOPROTEINASE;

EID: 15544378130     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-005-0073-6     Document Type: Review
Times cited : (18)

References (59)
  • 1
    • 0017055252 scopus 로고
    • ML-236A, ML-236B and ML-236C, new inhibitors of cholesterolgenesis produced by Penicillium citrinum
    • Endo A, Kuroda M, Tsujita Y: ML-236A, ML-236B and ML-236C, new inhibitors of cholesterolgenesis produced by Penicillium citrinum. J Antibiot 1976, 29:1346-1348.
    • (1976) J. Antibiot. , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 2
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group
    • Scandinavian Simvastatin Survival Study Group: Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 3
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Shepherd J, Cobbe SM, Ford I, et al.: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995, 333:1301-1307.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 4
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks FM, Pfeffer MA, Lemuel A: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996, 335:1001-1009.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Lemuel, A.3
  • 5
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group: Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998, 339:1349-1357.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1349-1357
  • 6
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels
    • Downs JR, Clearfield M, Weis S, et al.: Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels. JAMA 1998, 279:1615-1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 7
    • 0000306390 scopus 로고    scopus 로고
    • Statins do more than just lower cholesterol
    • Vaughan CJ, Murphy MB, Buckley BM: Statins do more than just lower cholesterol. Lancet 1996, 348:1079-1082.
    • (1996) Lancet , vol.348 , pp. 1079-1082
    • Vaughan, C.J.1    Murphy, M.B.2    Buckley, B.M.3
  • 8
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 1990, 343:425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 9
    • 0034053890 scopus 로고    scopus 로고
    • Non-lipid-related effects of statins
    • Bellosta S, Ferri N, Bernini F, et al.: Non-lipid-related effects of statins. Ann Med 2000, 32: 64-176.
    • (2000) Ann. Med. , vol.32 , pp. 164-176
    • Bellosta, S.1    Ferri, N.2    Bernini, F.3
  • 10
    • 2642536741 scopus 로고    scopus 로고
    • Inflammation,: Immunity, and HMG-CoA reductase inhibitors
    • Schonbeck U, Libby P: Inflammation, immunity, and HMG-CoA reductase inhibitors. Circulation 2004, 109:II-18-II-26.
    • (2004) Circulation , vol.109
    • Schonbeck, U.1    Libby, P.2
  • 11
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • Ross R: Atherosclerosis - an inflammatory disease. N Engl J Med 1999, 340:115-126.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 12
    • 0028261621 scopus 로고
    • Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits
    • Cayatte AJ, Palacino JJ, Horten K, et al.: Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 1994, 14:753-759.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 753-759
    • Cayatte, A.J.1    Palacino, J.J.2    Horten, K.3
  • 13
    • 0028016471 scopus 로고
    • Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury
    • Hamon M, Vallet B, Bauters C, et al.: Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury. Circulation 1994, 90:1357-1362.
    • (1994) Circulation , vol.90 , pp. 1357-1362
    • Hamon, M.1    Vallet, B.2    Bauters, C.3
  • 14
    • 0031032831 scopus 로고    scopus 로고
    • Simvastatin, an HMG-CoA reductase inhibitor, improves endothelial function within 1 month
    • O'Driscoll G, Green D, Taylor RR: Simvastatin, an HMG-CoA reductase inhibitor, improves endothelial function within 1 month. Circulation 1997, 95:1126-1131.
    • (1997) Circulation , vol.95 , pp. 1126-1131
    • O'Driscoll, G.1    Green, D.2    Taylor, R.R.3
  • 15
    • 0033596924 scopus 로고    scopus 로고
    • Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking
    • Newby DE, Wright RA, Labinjoh C, et al.: Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking. Circulation 1999, 99:1411-1415.
    • (1999) Circulation , vol.99 , pp. 1411-1415
    • Newby, D.E.1    Wright, R.A.2    Labinjoh, C.3
  • 16
    • 0028918698 scopus 로고
    • Impaired endothelium-dependent vasodilation in patients with essential hypertension: Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway
    • Panza JA, Garcia CE, Kilcoyne CM, et al.: Impaired endothelium-dependent vasodilation in patients with essential hypertension: Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 1995, 91: 732-1738.
    • (1995) Circulation , vol.91 , pp. 1732-1738
    • Panza, J.A.1    Garcia, C.E.2    Kilcoyne, C.M.3
  • 17
    • 0033165758 scopus 로고    scopus 로고
    • Hyperglycemia rapidly supresses flow-mediated endothelium-dependent vasodilation of brachial artery
    • Kawano H, Motoyama T, Hirashima O, et al.: Hyperglycemia rapidly supresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999, 34: 46-154.
    • (1999) J. Am. Coll. Cardiol. , vol.34 , pp. 146-154
    • Kawano, H.1    Motoyama, T.2    Hirashima, O.3
  • 18
    • 0026071074 scopus 로고
    • Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis
    • Liao JK, Bettmann MA, Sandor T, et al.: Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis. Circ Res 1991, 68:1027-1034.
    • (1991) Circ. Res. , vol.68 , pp. 1027-1034
    • Liao, J.K.1    Bettmann, M.A.2    Sandor, T.3
  • 19
    • 0025366847 scopus 로고
    • An L-arginine/nitric oxide pathway present in human platelets regulates aggregation
    • Radomski MW, Palmer RM, Moncada S: An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci U S A 1990, 87:5193-5197.
    • (1990) Proc. Natl. Acad. Sci. U S A , vol.87 , pp. 5193-5197
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 20
    • 0024553336 scopus 로고
    • Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
    • Garg UC, Hassid A: Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989, 83:1774-1777.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1774-1777
    • Garg, U.C.1    Hassid, A.2
  • 21
  • 22
    • 0034625373 scopus 로고    scopus 로고
    • Structure and function of sphingolipid and cholesterol-rich membrane rafts
    • Brown D, London E: Structure and function of sphingolipid and cholesterol-rich membrane rafts. J Biol Chem 2000, 275: 7221-17224.
    • (2000) J. Biol. Chem. , vol.275 , pp. 17221-17224
    • Brown, D.1    London, E.2
  • 23
    • 0032488818 scopus 로고    scopus 로고
    • The endothelial nitric-oxide synthase-caveolin regulatory cycle
    • Feron O, Saldana F. Michel JB, et al.: The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem 1998, 273:3125-3128.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3125-3128
    • Feron, O.1    Saldana, F.2    Michel, J.B.3
  • 24
    • 0031014389 scopus 로고    scopus 로고
    • Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
    • Tamai O, Matsuoka H, Itabe H, et al.: Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. Circulation 1997, 95:76-82.
    • (1997) Circulation , vol.95 , pp. 76-82
    • Tamai, O.1    Matsuoka, H.2    Itabe, H.3
  • 25
    • 3242733932 scopus 로고    scopus 로고
    • Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors
    • Harris MB, Blackstone MA, Sood SG, et al.: Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Am J Physiol Heart Circ Physiol 2004, 287:H560-H566.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.287
    • Harris, M.B.1    Blackstone, M.A.2    Sood, S.G.3
  • 26
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-Methylglutaryl coenzyme A reductase inhibitors
    • Takemoto M, Liao, J: Pleiotropic effects of 3-hydroxy-3-Methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol 2001, 21:1712-1719.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.2
  • 27
    • 0035830412 scopus 로고    scopus 로고
    • Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance
    • Feron O, Dessy C, Desager JP, et al.: Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001, 103:113-118.
    • (2001) Circulation , vol.103 , pp. 113-118
    • Feron, O.1    Dessy, C.2    Desager, J.P.3
  • 28
    • 0034696681 scopus 로고    scopus 로고
    • Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: Key role of L-arginine availability
    • Vergnani L, Hatrik S, Ricci F, et al.: Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation 2000, 101:1261-1266.
    • (2000) Circulation , vol.101 , pp. 1261-1266
    • Vergnani, L.1    Hatrik, S.2    Ricci, F.3
  • 29
    • 0035192759 scopus 로고    scopus 로고
    • Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits
    • Rikitake Y, Kawashima S, Takeshita S, et al.: Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 2001, 154:87-96.
    • (2001) Atherosclerosis , vol.154 , pp. 87-96
    • Rikitake, Y.1    Kawashima, S.2    Takeshita, S.3
  • 30
    • 0027242030 scopus 로고
    • Hypercholseterolemia increases endothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG: Hypercholseterolemia increases endothelial superoxide anion production. J Clin Invest 1993, 91:2546-2551.
    • (1993) J. Clin. Invest. , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 31
    • 0033554455 scopus 로고    scopus 로고
    • Dietary lipid lowering reduces tissue factor expression in rabbit atheroma
    • Aikawa M, Voglic SJ, Sugiyama S, et al.: Dietary lipid lowering reduces tissue factor expression in rabbit atheroma. Circulation 1999, 100:1215-1222.
    • (1999) Circulation , vol.100 , pp. 1215-1222
    • Aikawa, M.1    Voglic, S.J.2    Sugiyama, S.3
  • 32
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    • Ridker PM, Rifai N, Rose L, et al.: Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002, 347:1557-1565.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3
  • 33
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the prevention of acute coronary events
    • Ridker PM, Rifai N, Clearfield M, et al.: Measurement of C-reactive protein for the targeting of statin therapy in the prevention of acute coronary events. N Engl J Med 2001, 344:1959-1965.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3
  • 34
    • 0030838319 scopus 로고    scopus 로고
    • HMG-CoA recuctase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes; To endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypecholesterolemia
    • Weber C, Erl W, Weber KS, et al.: HMG-CoA recuctase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes; to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypecholesterolemia. J Am Coll Cardiol 1997, 30:1212-1217.
    • (1997) J. Am. Coll. Cardiol. , vol.30 , pp. 1212-1217
    • Weber, C.1    Erl, W.2    Weber, K.S.3
  • 35
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt G, Welzenbach K, Brinkmann V, et al.: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001, 7:687-692.
    • (2001) Nat. Med. , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3
  • 36
    • 0034747925 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein- 1 expression in early lesions from hypercholesterolic swine independently of their effect on plasma cholesterol levels
    • Martinez-Gonzalez J, Alfon J, Berrozpe M, et al.: HMG-CoA reductase inhibitors reduce vascular monocyte chemotactic protein- 1 expression in early lesions from hypercholesterolic swine independently of their effect on plasma cholesterol levels. Atherosclerosis 2001, 159:27-33.
    • (2001) Atherosclerosis , vol.159 , pp. 27-33
    • Martinez-Gonzalez, J.1    Alfon, J.2    Berrozpe, M.3
  • 37
    • 0032494101 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
    • Guijarro C, Blanco-Colio LM, Ortego M, et al.: 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res 1998, 83:490-500.
    • (1998) Circ. Res. , vol.83 , pp. 490-500
    • Guijarro, C.1    Blanco-Colio, L.M.2    Ortego, M.3
  • 38
    • 0029022554 scopus 로고
    • Apoptosis in human atherosclerosis and restenosis
    • Isner J: Apoptosis in human atherosclerosis and restenosis. Circulation 1995, 91:2703-2711.
    • (1995) Circulation , vol.91 , pp. 2703-2711
    • Isner, J.1
  • 39
    • 0037065914 scopus 로고    scopus 로고
    • Statins have biphasic effects on angiogenesis
    • Weis M, Heeschen C, Glassford A, et al.: Statins have biphasic effects on angiogenesis. Circulation 2002, 105: 39-745.
    • (2002) Circulation , vol.105 , pp. 739-745
    • Weis, M.1    Heeschen, C.2    Glassford, A.3
  • 40
    • 0037197723 scopus 로고    scopus 로고
    • Induction of atherosclerotic plaque rupture in apoliproprotein E-/- mice after adenovirus-mediated transfer of p53
    • von der Thusen JH, van Vlijmen BJ, Hoeben RC, et al.: Induction of atherosclerotic plaque rupture in apoliproprotein E-/- mice after adenovirus-mediated transfer of p53. Circulation 2002, 105:2064-2070.
    • (2002) Circulation , vol.105 , pp. 2064-2070
    • von der Thusen, J.H.1    van Vlijmen, B.J.2    Hoeben, R.C.3
  • 41
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
    • Crisby M, Nordin-Fredriksson C, Shah PK, et al.: Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation 2001, 103:926-933.
    • (2001) Circulation , vol.103 , pp. 926-933
    • Crisby, M.1    Nordin-Fredriksson, C.2    Shah, P.K.3
  • 42
    • 15544365501 scopus 로고    scopus 로고
    • Role of apoptosis in atherosclerosis and its therapeutic implications
    • Stoneman V, Bennett M: Role of apoptosis in atherosclerosis and its therapeutic implications. Clin Sci 2004, 86:1-23.
    • (2004) Clin. Sci. , vol.86 , pp. 1-23
    • Stoneman, V.1    Bennett, M.2
  • 43
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • Aikawa M, Rabkin E, Sugiyama S, et al.: An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro. Circulation 2001, 103:276-283.
    • (2001) Circulation , vol.103 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3
  • 44
    • 0032487342 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins
    • Essig M, Nguyen G, Prie D, et al.: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins. Circ Res 1998, 83: 83-690.
    • (1998) Circ. Res. , vol.83 , pp. 683-690
    • Essig, M.1    Nguyen, G.2    Prie, D.3
  • 45
    • 0033966049 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
    • Bourcier T, Libby P: HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol 2000, 20:556-562.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 556-562
    • Bourcier, T.1    Libby, P.2
  • 47
    • 0035861757 scopus 로고    scopus 로고
    • Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins
    • Degraeve F, Bolla M, Blaie S, et al.: Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. J Biol Chem 2001, 276:46849-46855.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46849-46855
    • Degraeve, F.1    Bolla, M.2    Blaie, S.3
  • 48
    • 4143083577 scopus 로고    scopus 로고
    • Prior statin therapy is associated with a decreased rate of severe sepsis
    • Almog Y, Shefer A, Novack V, et al.: Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 2004, 110:880-885.
    • (2004) Circulation , vol.110 , pp. 880-885
    • Almog, Y.1    Shefer, A.2    Novack, V.3
  • 49
    • 0041431121 scopus 로고    scopus 로고
    • Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy
    • Node K, Fujita M, Kitakaze M, et al.: Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation 2003, 108: 39-843.
    • (2003) Circulation , vol.108 , pp. 839-843
    • Node, K.1    Fujita, M.2    Kitakaze, M.3
  • 50
    • 0029119711 scopus 로고
    • Effect of pravastatin on outcomes after cardiac transplantation
    • Kobashigawa J, Katznelson S, Laks H, et al.: Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995, 333:621-627.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 621-627
    • Kobashigawa, J.1    Katznelson, S.2    Laks, H.3
  • 51
    • 0033053063 scopus 로고    scopus 로고
    • Apoptosis of vascular smooth muscle cells in vascular remodeling and atherosclerotic plaque rupture
    • Bennett MR: Apoptosis of vascular smooth muscle cells in vascular remodeling and atherosclerotic plaque rupture. Cardiovasc Res 1999, 41:361-368.
    • (1999) Cardiovasc. Res. , vol.41 , pp. 361-368
    • Bennett, M.R.1
  • 52
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, et al.: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Med 2000, 6:1004- 1010.
    • (2000) Nature Med. , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 53
    • 2542443477 scopus 로고    scopus 로고
    • Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis
    • Sata M, Nishimatsu H, Osuga J, et al.: Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. Hypertension 2004, 43: 214-1220.
    • (2004) Hypertension , vol.43 , pp. 1214-1220
    • Sata, M.1    Nishimatsu, H.2    Osuga, J.3
  • 54
    • 0035876762 scopus 로고    scopus 로고
    • Do statins cause cancer? A meta-analysis of large randomized clinical trials
    • Bjere LM, LeLorier J: Do statins cause cancer? A meta-analysis of large randomized clinical trials. Am J Med 2001, 110:716-723.
    • (2001) Am. J. Med. , vol.110 , pp. 716-723
    • Bjere, L.M.1    LeLorier, J.2
  • 55
    • 0036239832 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis
    • Wong WW, Dimitroulakos J, Minden MD, et al.: HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 2002, 16: 08-519.
    • (2002) Leukemia , vol.16 , pp. 508-519
    • Wong, W.W.1    Dimitroulakos, J.2    Minden, M.D.3
  • 56
    • 15544366758 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors and the risk of colorectal cancer
    • Presented at the 2004 American Society of Clinical Oncology. New Orleans, June 5-8
    • Poynter J: HMG CoA reductase inhibitors and the risk of colorectal cancer. Presented at the 2004 American Society of Clinical Oncology. New Orleans, June 5-8, 2004.
    • (2004)
    • Poynter, J.1
  • 57
    • 2442561768 scopus 로고    scopus 로고
    • Oral simvastatin treatment in relapsing-remitting multiple sclerosis
    • Vollmer T, Lyndon K, Durkalski V, et al.: Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 2004, 363:1607-1608.
    • (2004) Lancet , vol.363 , pp. 1607-1608
    • Vollmer, T.1    Lyndon, K.2    Durkalski, V.3
  • 58
    • 0041464676 scopus 로고    scopus 로고
    • Therapy with statins in patients with refractory rheumatic diseases: A preliminary study
    • Abud-Mendoza C, de la Fuente H, Cuevas-Orta E, et al.: Therapy with statins in patients with refractory rheumatic diseases: a preliminary study. Lupus 2003, 12:607-611.
    • (2003) Lupus , vol.12 , pp. 607-611
    • Abud-Mendoza, C.1    de la Fuente, H.2    Cuevas-Orta, E.3
  • 59
    • 0346690415 scopus 로고    scopus 로고
    • The pleiotropic effects of HMG-CoA reductase inhibitors: Their role in osteoporosis and dementia
    • Waldman A, Kritharides L: The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia. Drugs 2003, 63:139-152.
    • (2003) Drugs , vol.63 , pp. 139-152
    • Waldman, A.1    Kritharides, L.2


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