Pathogenesis of ventilator-induced lung injury: Trials and tribulations

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 288, Issue 4 32-4, 2005, Pages

  Tremblay, Lorraine N ^a,b   Slutsky, Arthur S ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2 ANTIBODY; CYTOKINE; GADOLINIUM; GENISTEIN; ISOPRENALINE; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MACROPHAGE INFLAMMATORY PROTEIN 2 ANTIBODY; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; MYOSIN LIGHT CHAIN KINASE INHIBITOR; PENTOXIFYLLINE; PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; STEROID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

AIRWAY PRESSURE; ANTIINFLAMMATORY ACTIVITY; ARTIFICIAL VENTILATION; BAROTRAUMA; CELL COUNT; CYTOKINE PRODUCTION; EDITORIAL; HUMAN; INFECTION COMPLICATION; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG BLOOD VESSEL; LUNG CAPILLARY; LUNG INFILTRATE; LUNG INJURY; LUNG LAVAGE; LUNG VOLUME; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VENTILATOR INDUCED LUNG INJURY;

ANIMALS; CHEMOKINES; HUMANS; LUNG; RECEPTORS, TUMOR NECROSIS FACTOR; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 15544365658     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00438.2004     Document Type: Editorial

References (46)

1. Abraham E. Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med 25: 556-566, 1999.
2. Belperio J, Keane MP, Burdick M, Londhe V, Xue Y, Li K, Phillips R, and Strieter R. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 110: 1703-1716, 2002.
3. Bregeon F, Roch A, Delpierre S, Ghigo E, Autillo-Touati A, Kajikawa O, Martin TR, Pugin J, Portugal H, Auffray JP, and Jammes Y. Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. Respir Physiol 132: 191-203, 2002.
4. Bueno PC, Bueno CE, Santos ML, Oliveira-Junior I, Salomao R, Pinheiro BV, and Beppu OS. Ventilation with high tidal volume induces inflammatory lung injury. Braz J Med Biol Res 35: 191-198, 2002.
5. Choudhury S, Wilson MR, Goddard ME, O'Dea KP, and Takata M. Mechanisms of early pulmonary neutrophil sequestration in ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 287: L902-L910, 2004.
6. Copland IB, Martinez F, Kavanagh BP, Engelberts D, McKerlie C, Belik J, and Post M. High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung. Am J Respir Crit Care Med 169: 739-748, 2004.
7. Debs RJ, Fuchs HJ, Philip M, Montgomery AB, Brunette EN, Liggitt D, Patton JS, and Shellito JE. Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats. J Immunol 140: 3482-3488, 1988.
8. Dreyfuss D and Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157: 294-323, 1998.
9. Foda HD, Rollo EE, Drews M, Conner C, Appelt K, Shalinsky DR, and Zucker S. Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN. Attenuation by the synthetic matrix metalloproteinase inhibitor, prinomastat (ag3340). Am J Respir Cell Mol Biol 25: 717-724, 2001.
10. Guery BP, Welsh DA, Viget NB, Robriquet L, Fialdes P, Mason CM, Beaucaire G, Bagby GJ, and Neviere R. Ventilation-induced lung injury is associated with an increase in gut permeability. Shock 19: 559-563, 2003.
11. Gurkan OU, O'Donnell C, Brower R, Ruckdeschel E, and Becker PM. Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol 285: L710-L718, 2003.
12. Held H, Boettcher S, Hamann L, and Uhlig S. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-κB and is blocked by steroids. Am J Respir Crit Care Med 163: 711-716, 2001.
13. Imai Y, Kawano T, Iwamoto S, Nakagawa S, Takata M, and Miyasaka K. Intratracheal anti-tumor necrosis factor-α antibody attenuates ventilator-induced lung injury in rabbits. J Appl Physiol 87: 510-515, 1999.
14. Kawano T, Mori S, Cybulsky M, Burger R, Ballin A, Cutz E, and Bryan AC. Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 62: 27-33, 1987.
15. Kurahashi K, Ota S, Nakamura K, Nagashima Y, Yazawa T, Satoh M, Fujita A, Kamiya R, Fujita E, Baba Y, Uchida K, Morimura N, Andoh T, and Yamada Y. Effect of lung-protective ventilation on severe Pseudomonas aeruginosa pneumonia and sepsis in rats. Am J Physiol Lung Cell Mol Physiol 287: L402-L410, 2004.
16. Martin TR. Neutrophils and lung injury: getting it right. J Clin Invest 110: 1603-1605, 2002.
17. Moriyama K, Ishizaka A, Nakamura M, Kubo H, Kotani T, Yamamoto S, Ogawa EN, Kajikawa O, Frevert CW, Kotake Y, Morisaki H, Koh H, Tasaka S, Martin TR, and Takeda J. Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. Am J Physiol Lung Cell Mol Physiol 286: L1114-L1121, 2004.
18. Naik AS, Kallapur SG, Bachurski CJ, Jobe AH, Michna J, Kramer BW, and Ikegami M. Effects of ventilation with different positive end-expiratory pressures on cytokine expression in the preterm lamb lung. Am J Respir Crit Care Med 164: 494-498, 2001.
19. Noda E, Hoshina H, Watanabe H, and Kawano T. Production of TNF-α by polymorphonuclear leukocytes during mechanical ventilation in the surfactant-depleted rabbit lung. Pediatr Pulmonol 36: 475-481, 2003.
20. Oliveira IS, Pinheiro BV, Silva ID, Salomao R, Zollner RL, and Beppu OS. Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume. Braz J Med Biol Res 36: 1349-1357, 2003.
21. Parker JC. Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury. J Appl Physiol 89: 2241-2248, 2000.
22. Parker JC and Ivey CL. Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 83: 1962-1967, 1997.
23. Parker JC, Ivey CL, and Tucker JA. Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 84: 1113-1118, 1998.
24. Pinhu L, Whitehead T, Evans T, and Griffiths M. Ventilator-associated lung injury. Lancet 361: 332-340, 2003.
25. Plotz FB, Slutsky AS, van Vught AJ, and Heijnen CJ. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 30: 1865-1872, 2004.
26. Plotz FB, Vreugdenhil HA, Slutsky AS, Zijlstra J, Heijnen CJ, and van Vught H. Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med 28: 486-492, 2002.
27. Pugin J. Molecular mechanisms of lung cell activation induced by cyclic stretch. Crit Care Med 31: S200-S206, 2003.
28. Quinn DA, Moufarrej RK, Volokhov A, and Hales CA. Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 93: 517-525, 2002.
29. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, and Slutsky AS. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282: 54-61, 1999.
30. Ribeiro SP, Rhee K, Tremblay L, Veldhuizen R, Lewis JF, and Slutsky AS. Heat stress attenuates ventilator-induced lung dysfunction in an ex vivo rat lung model. Am J Respir Crit Care Med 163: 1451-1456, 2001.
31. Ricard JD, Dreyfuss D, and Saumon G. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med 163: 1176-1180, 2001.
32. Rich PB, Douillet CD, Hurd H, and Boucher RC. Effect of ventilatory rate on airway cytokine levels and lung injury. J Surg Res 113: 139-145, 2003.
33. Rimensberger PC, Fedorko L, Cutz E, and Bohn DJ. Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669). Crit Care Med 26: 548-555, 1998.
34. Slutsky AS. Lung injury caused by mechanical ventilation. Chest 116, Suppl 1: 9S-15S, 1999.
35. Slutsky AS and Tremblay LN. Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 157: 1721-1725, 1998.
36. Stamme C, Brasch F, von Bethmann A, and Uhlig S. Effect of surfactant on ventilation-induced mediator release in isolated perfused mouse lungs. Pulm Pharmacol 15: 455-461, 2002.
37. Stuber F, Wrigge H, Schroeder S, Wetegrove S, Zinserling J, Hoeft A, and Putensen C. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med 28: 834-841, 2002.
38. Takata M, Abe J, Tanaka H, Kitano Y, Doi S, Kohsaka T, and Miyasaka K. Intraalveolar expression of tumor necrosis factor-α gene during conventional and high-frequency ventilation. Am J Respir Crit Care Med 156: 272-279, 1997.
39. Tremblay L, Valenza F, Ribeiro SP, Li J, and Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 99: 944-952, 1997.
40. Tremblay LN, Miatto D, Hamid Q, Govindarajan A, and Slutsky AS. Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-α and interleukin-6 messenger RNA. Crit Care Med 30: 1693-1700, 2002.
41. Tremblay LN and Slutsky AS. Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 110: 482-488, 1998.
42. Uhlig S, Ranieri M, Slutsky AS. Biotrauma hypothesis of ventilator-induced lung injury. Am J Respir Crit Care Med 169: 314-315, 2004.
43. Verbrugge SJ, Uhlig S, Neggers SJ, Martin C, Held HD, Haitsma JJ, and Lachmann B. Different ventilation strategies affect lung function but do not increase tumor necrosis factor-α and prostacyclin production in lavaged rat lungs in vivo. Anesthesiology 91: 1834-1843, 1999.
44. Wainwright MS, Rossi J, Schavochy J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, and Van Eldik LJ. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci USA 100: 6233-6238, 2003.
45. Wilson MR, Choudhury S, Goddard ME, O'Dea KP, Nicholson AG, and Takata M. High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol 95: 1385-1393, 2003.
46. Wilson MR, Choudhury S, and Takata M. Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice. Am J Physiol Lung Cell Mol Physiol 288: L599-L607, 2005.