Under-nutrition in older people: A serious and growing global problem!

Journal of Postgraduate Medicine

Volumn 49, Issue 4, 2003, Pages 352-360

  Visvanathan, Renuka ^a,b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b NONE   (Australia)

Author keywords

Elderly; Outcome; Prevalence; Under nutrition

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CHOLECYSTOKININ; CYTOKINE; GHRELIN; LEPTIN; TESTOSTERONE; ZINC;

AGED; AGING; ANOREXIA; DIET SUPPLEMENTATION; DIETARY INTAKE; HUMAN; MORBIDITY; MORTALITY; MUSCLE ATROPHY; NUTRITIONAL REQUIREMENT; NUTRITIONAL SUPPORT; PATHOPHYSIOLOGY; PREVALENCE; PROTEIN CALORIE MALNUTRITION; PSYCHOLOGICAL ASPECT; PUBLIC HEALTH; REVIEW; RISK FACTOR; SATIETY; SOCIAL ASPECT; SOCIAL ISOLATION; STOMACH DISTENSION; STOMACH EMPTYING; WEIGHT REDUCTION; APPETITE; ARTICLE; HEALTH; NUTRITIONAL DISORDER; NUTRITIONAL STATUS; PHYSIOLOGY;

AGED; ANOREXIA; APPETITE; HUMANS; NUTRITION DISORDERS; NUTRITIONAL STATUS; PREVALENCE; PROTEIN-ENERGY MALNUTRITION; WORLD HEALTH;

EID: 1542749364     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Butler RN. Population aging and health. BMJ 1997;315:1082-4.
2. Hobbs F, Damon B. 65+ in the United States, In: Current Population Reports. Washington DC: US Bureau of Census; 1996. pp. 23-190.
3. de Groot CP, van Staveren WA, de Graaf C. Determinants of macronutrient intake in elderly people. Eur J Clin Nutr 2000;54:S70-6.
4. de Groot CPGM, van Staveren WA. Undernutrition in the European SENECA studies. Clin Geriatr Med 2002;18:699-708.
5. MacIntosh C, Morley JE, Chapman IM. The anorexia of aging. Nutrition 2000;16:983-95.
6. Morley JE. Neuropeptide regulation of appetite and weight. Endocr Rev 1987;8:256-87.
7. Levine AS, Morley JE, Gosnell BA, Billington CJ, Bartness TJ. Opioids and consumatory behaviour. Brain Res Bull 1985;14:663-72.
8. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kanagawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.
9. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, et al. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 2000;23:493-5.
10. Muccioli G, Tschop M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 2002;440:235-54.
11. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 2001;86:1169-74.
12. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85:4908-11.
13. Rigamonti AE, Pincelli AI, Corra B, Viarengo R, Bonomo SM, Galimberti D, et al. Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J Endocrinol 2002;175:R1-5.
14. Sturm K, MacIntosh CG, Parker BA, Wishart J, Horowitz M, Chapman IM. Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin and other gastrointestinal hormones in undernourished older women and well-nourished young and older women. J Clin Endocrinol Metab 2003;88:3747-55.
15. Kaneda H, Maeshima K, Goto N, Kobayakawa T, Ayabe-Kanamura S, Saito S. Decline in taste an odor discrimination abilities with age, and relationship between gustation and olfaction. Chem Senses 2000;25:331-7.
16. Tuorila H, Niskanen N, Maunuksela E. Perception and pleasantness of a food with varying odor and flavor among the elderly and young. J Nutr Health Aging. 2001;5:266-8.
17. Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. Smell identification ability: changes with age. Science 1984;226:1441-3.
18. Schiffman SS, Graham BG. Taste and smell perception affect appetite and immunity in the elderly. Eur J Clin Nutr 2000;54:S54-63.
19. Rolls BJ, McDermott TM. Effects of age on sensory-specific satiety. Am J Clin Nutr 1991;54:988-96.
20. Grundy D, Salih AA, Scratcherd T. Modulation of vagal efferent fibre discharge by mechanoreceptors in the stomach, duodenum and colon of the ferret. J Physiol 1981;319:43-52.
21. Jones KL, Doran SM, Hveem K, Bartholomeusz FD, Morley JE, Sun WM, et al. Relation between postprandial satiation and antral area in normal subjects. Am J Clin Nutr 1997;66:127-32.
22. Kupfer RM, Heppell M, Haggith JW, Bateman DN. Gastric emptying and small-bowel transit rate in the elderly. J Am Geriatr Soc 1985;33:340-3.
23. Rayner CK, MacIntosh CG, Chapman IM, Morley JE, Horowitz M. Effect of age on proximal gastric motor and sensory function. Scand J Gastroenterol 2000;35:1041-7.
24. Clarkston WK, Pantano MM, Morley JE, Horowitz M, Littlefield JM, Burton FR. Evidence for the anorexia of aging: gastrointestinal transit and hunger in healthy elderly vs. young adults. Am J Physiol 1997;272:R243-8.
25. Peikin SR. Role of cholecystokinin in the control of food intake. Gastroenterol Clin North Am 1989;18:757-75.
26. Morley JE. Appetite regulation: the role of peptides and hormones. J Endocrinol Invest 1989;12:135-47.
27. Moran TH, McHugh PR. Gastric and nongastric mechanisms for satiety action of cholecystokinin. Am J Physiol 1988;254:R628-32.
28. Fraser R, Fone D, Horowitz M, Dent J. Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans. Gut 1993;34:33-7.
29. Feinle C, D'Amato M, Read NW. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid. Gastroenterology 1996;110:1379-85.
30. Sandstrom O, El-Salhy M. Ageing and endocrine cells of human duodenum. Mech Ageing Dev 1999;108:39-48.
31. MacIntosh CG, Andrews JM, Jones KL, Wishart JM, Morris HA, Jansen JB, et al. Effects of age on concentration of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr 1999;69:999-1006.
32. Morley JE, Perry HM 3rd, Baumgartner RP, Garry PJ. Leptin, adipose tissue and aging - is there a role for testosterone? J Gerontol A Biol Sci Med Sci 1999;54: B108-10.
33. Larsson H, Elmstahl S, Berglund G, Ahren B. Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab 1998;83:4382-5.
34. Castracane VD, Kraemer RR, Franken MA, Kraemer GR, Grimpel T. Serum leptin concentration in women: effect of age, obesity, and estrogen administration. Fertil Steril 1998;70:472-7.
35. Sih R, Morley JE, Kaiser FE, Perry HM 3rd, Patrick P, Ross C. Testosterone replacement in older hypogonadal mean: a 12-month randomised controlled trial. J Clin Endocrinol Metab 1997;82:1661-7.
36. Baez-Franceschi D, Morley JE. Pathophysiology of catabolism in undernourished elderly patients (in German]. Z Gerontol Geriatr 1999;32:112-9.
37. Anker SD, Chua TP, Ponikowski P, Harrington D, Swan JW, Kox WJ, et al. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997;96:526-34.
38. Yeh SS, Schuster MW. Geriatric cachexia: the role of cytokines. Am J Clin Nutr 1999;70:183-97.
39. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997;127:990-91S.
40. Roubenoff R, Hughes VA. Sarcopenia: current concepts. J Gerontol A Biol Sci Med Sci 2000;55:M716-24.
41. Lindle RS, Metter EJ, Lynch NA, Fleg JL, Fozard JL, Tobin J, et al. Age and gender comparisons of muscle strength in 654 women and men aged 20-93 years. J Appl Physiol 1997;83:1581-7.
42. Ivey FM, Tracy BL, Lemmer JT, NessAiver M, Metter EJ, Fozard JL, et al. Effects of strength training and detraining on muscle quality: age and gender comparisons. J Gerontol Biol Sci Med Sci 2000;55:B152-7.
43. Lexell J. Human aging, muscle mass, and fibre type composition. J Gerontol A Biol Sci Med Sci 1995;50:A11-6.
44. Short KR, Nair KS. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care 2000;3:39-44.
45. Andersen JL, Terzis G, Kryger A. Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibres of the very old. Muscle Nerve 1999;22:449-54.
46. Sica RE, Sanz OP, Colombi A. The effects of ageing upon the human soleus muscle. An electrophysiological study. Medicina 1976;36:443-6.
47. Erim Z, Beg MF, Burke DT, de Lucia CJ. Effects of aging on motor-unit control properties. J Neurophysiol 1999;82:2081-91.
48. Brown WF. A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. J Neurol Neurosurg Psychiatry 1972;35:845-52.
49. Grinspoon S, Corcoran C, Miller K, Biller BM, Askari H, Wang E, et al. Body composition and endocrine function in women with acquired immunodeficiency syndrome wasting. J Clin Endocrinol Metab 1997;82:1332-7.
50. Volpi E, Sheffield-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 2001;286:1206-12.
51. Morley JE. Testosterone replacement and the physiologic aspects of aging in men. Mayo Clin Proc 2000;75:S83-7.
52. Melton LK 3rd, Khosla S, Riggs BL. Epidemiology of sarcopenia. Mayo Clin Proc 2000;75:S10-3.
53. Roubenoff R, Rall LC, Veldhuis JD, Kehayias JJ, Rosen C, Nicolson M, et al. The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin. J Clin Endocrinol Metab 1998;83:1502-6.
54. Tenover JS. Androgen replacement therapy to reverse and/or prevent age-associated sarcopenia in men. Baillieres Clin Endocrinol Metab 1998;12:419-25.
55. Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab 1999;84:1886-91.
56. Morley JE. Testosterone replacement in older men and women. J Gend Specif Med 2001;4:49-53.
57. Morley JE. Androgens and aging. Maturitas 2001;38:71-3.
58. Kenny AM, Dawson L, Kleppinger A, Iannuzzi-Sucich M, Judge JO. Prevalence of sarcopenia and predictors of skeletal muscle mass in nonobese women who are long-term users of estrogen-replacement therapy. J Gerontol A Biol Sci Med Sci 2003;58:M436-40.
59. Rantanen T, Era P, Heikkinen E. Physical activity and changes in maximal isometric strength in men and women from the age of 75 to 80 years. J Am Geriatr Soc 1997;45:1439-45.
60. Sandvik L, Erikssen J, Thaulow E, Erikssen G, Mundal R, Rodahl K. Physical fitness as a predictor of mortality among healthy, middle aged Norwegian men. N Eng J Med 1993;328:533-7.
61. Hortobagyi T, Dempsey L, Fraser D, Zheng D, Hamilton G, Lambert J, et al. Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans. J Physiol 2000;524:293-304.
62. Castaneda C, Charnley JM, Evans WJ, Crim MC. Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response. Am J Clin Nutr 1995;62:30-9.
63. Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 2002;50:1947-54.
64. Nelson K, Brown ME, Lurie N. Hunger in an adult patient population. JAMA 1998;279:1211-4.
65. Guarnieri G, Antonione R, Biolo G. Mechanisms of malnutrition in uremia. J Ren Nutr 2003;13:153-7.
66. Walker D, Beauchene RE. The relationship of loneliness, social isolation, and physical health to dietary adequacy of independently living elderly. J Am Diet Assoc 1991;91:300-4.
67. Brodaty H, Luscombe G, Parker G, Wilhelm K, Hickie I, Austin MP, et al. Increased rate of psychosis and psychomotor changes in depression with age. Psychol Med 1997;27:1205-13.
68. Grundman M, Corey-Bloom J, Jernigan T, Archibald S, Thal LJ. Low body weight in Alzheimer's disease is associated with mesial temporal cortex atrophy. Neurology 1996;46:1585-91.
69. Wolf-Klein GP, Silverstone FA, Levy AP. Nutritional patterns and weight change in Alzheimer patients. Int Psychogeriatr 1992;4:103-18.
70. Sahyoun NR, Lin CL, Krall E. Nutritional status of the older adult is associated with dentition status. J Am Diet Assoc 2003;103:61-6.
71. Shimazaki Y, Soh I, Saito T, Yamashita Y, Koga T, Miyazaki H, et al. Influence of dentition status on physical disability, mental impairment, and mortality in institutionalized elderly people. J Dent Res 2001;80:340-5.
72. Dwyer J. Strategies to detect and prevent malnutrition in the elderly: the Nutritional Screening Intiative. Nutr Today 1994;29:14-24.
73. Posner BM, Jette AM, Smith KW, Miller DR. Nutrition and health risks in the elderly: the nutritional screening intiative. Am J Public Health 1993;83:972-8.
74. Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999;15:116-22.
75. Guigoz Y, Vellas BJ, Garry PJ. Mini Nutritional Assessment: a practical assessment tool for grading the nutritional state of elderly patients. In: Vellas BJ, Guigoz Y, Garry PJ, Albarede JL, editors. The Mini Nutritional Assessment, Facts and Research in Gerontology (Supplement No 2). 2nd edn. Paris: Serdi Publishing Company; 1994. pp 15-59.
76. Cobendy R, Rubenstein LZ, Eledjam JJ. The Mini nutritional Assessment- Short Form for pre-operative nutritional evaluation of elderly patients. Aging (milano) 2001;13:293-7.
77. de Groot CPGM, Beck AM, Schroll M, van Staveren WA. Evaluating the DETERMINE Your Nutritional Health checklist and the Mini Nutritional Assessment as tools to identify nutritional problems in elderly Europeans. Eur J Clin Nutr 1998;52:877-83.
78. Visvanathan R, Macintosh C, Callary M, Penhall R, Horowitz M, Chapman I. The nutritional status of 250 older Australian recipients of domiciliary care services, and it's association with outcomes at 12 months. J Am Geriatr Soc 2003;51:1007-11.
79. Barone L, Milosavljevic M, Gazibarich B. Assessing the older person: Is the MNA more appropriate nutritional assessment tool than the SGA? J Nutr Health Aging 2003;7:433-7.
80. Persson MD, Brismar KE, Katzarski KS, Nordenstrom J, Cederholm TE. Nutritional status using mini nutritional assessment and subjective global assessment predict mortality in geriatric patients. J Am Geriatr Soc 2002;50:1996-2002.
81. Visvanathan R, Penhall R, Chapman I. Nutritional Screening of Older People in a Sub-acute Care Facility in Australia and its Relation to Discharge Outcomes. Age and Ageing (in press).
82. Saletti A, Lindgren EY, Johansson L, Cederholm T. Nutritional status according to the mini nutritional assessment in an institutionalised elderly population in Sweden. Gerontology 200;46:139-45.
83. Bales CW, Ritchie CS. Sarcopenia, weight loss, and nutritional frailty in the elderly. Ann Rev Nutr 2002;22:309-23.
84. de Jong N. Nutrition and Senescence: healthy aging for all in the new millennium? Nutrition 2000;16:537-41.
85. Wedick NM, Barrett-Connor E, Knoke JD, Wingard DL. The relationship between weight loss and all-cause mortality in older men and women with and without diabetes mellitus: the Rancho Bernado Study. J Am Geriatr Soc 2002;50:1810-5.
86. Newman AB, Yanez D, Harris T, Duzbury A, Enright PL, Fried LP, et al. Weight change in old age and its association with mortality. J Am Geriatr Soc 2001;49:1309-18.
87. Landi F, Onder G, Gambassi G, Pedone C, Carboni P, Bernabei R. Body mass index and mortality among hospitalized patients. Arch Intern Med 2000;160:2641-4.
88. Miller MD, Crotty M, Giles LC, Bannerman E, Whitehead C, Cobiac L, et al. Corrected arm muscle area: an independent predictor of long-term mortality in community-dwelling older adults? J Am Geriatr Soc 2002;50:1272-7.
89. Sullivan DH, Bopp MM, Roberson PK. Protein-energy undernutrition and life-threatening complications among the hospitalized elderly. J Gen Intern Med 2002;17:923-32.
90. Maurer M, Luchsinger JA, Wellner R, Kukuy E, Edwards NM. The effect of body mass index on complications from cardiac surgery in the oldest old. J Am Geriatr Soc 2002;50:988-94.
91. Windsor JA, Hill GL. Risk factors for post-operative pneumonia: the importance of protein depletion. Ann Surg 1988;208:209-14.
92. Heymsfield SB, Bethel RA, Ansley JD, Gibbs SM, Felner JM, Nutter DO. Cardiac abnormalities in cachectic patients before and during nutritional repletion. Am Heart J 1978;95:584-94.
93. Bistrian BR, Sherman M, Blackburn GL, Marshall R, Shaw C. Cellular immunity in adult marasmus. Arch Int Med 1977;137:1408-11.
94. Holmes R, MacChiano K, Jhangiani SS, Agarwal NR, Savino JA. Nutritional know-how. Combating pressure sores nutritionally. Am J Nurs 1987;87:1301-3.
95. Kaiser FE, Morley JE. Idiopathic CD4+ T lymphopenia in older persons. J Am Geriatr Soc 1994;42:1291-4.
96. Wissing U, Ek AC, Unosson M. A follow-up study of ulcer healing, nutrition, and life-situation in elderly patients with leg ulcers. J Nutr Health Aging 2001;5:37-42.
97. Milne AC, Potter J, Avenell A. Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 2002;3:CD003288.
98. Payette H, Boutier V, Coulombe C, Gray-Donald K. Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomised community trial. J Am Diet Assoc 2002; 102:1088-95.
99. Gray-Donald K, Payette H, Boutier V. Randomized clinical trial of nutritional supplementation shows little effect on functional status among free-living frail elderly. J Nutr 1995;125:2965-71.
100. Vellas BJ, Hunt WC, Romero LJ, Koehler KM, Baumgartner RN, Garry PJ. Nutrition 1997;13:515-9.
101. Chandra RK. Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects. Nutrition 2001;17:709-12.
102. Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr 2003;77:975-84.
103. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 2002;287:3230-7.
104. Thomas DR. Improving outcome of pressure ulcers with nutritional intervention: a review of the evidence. Nutrition 2001;17:121-5.
105. Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 2002;288:715-21.
106. Flood V, Smith W, Wang JJ, Manzi F, Webb K, Mitchell P. Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 2002;109:2272-8.
107. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 2001;119:1439-52.
108. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001;119:1417-36.
109. Lonn E, Yusuf S, Hoogwerf B, Pogue J, Yi Q, Zinman B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 2002;25:1919-27.
110. Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000;342:154-60.
111. Hetherington MM, Cameron F, Wallis DJ, Pirie LM. Stimulation of appetite by alcohol. Physiol Behav 2001;74:283-9.
112. Schiffman SS. Intensification of sensory properties of foods for the elderly. J Nutr 2000;130:927S-30S.
113. Stock LZ, Milan A. Improving dietary practices of elderly individuals: the power of prompting feedback, and social reinforcement. J Appl Behav Anal 1993;26:379-87.
114. Anderson JV, Bybee DI, Brown RM, McLean DF, Garcia EM, Breer L, et al. 5 a day fruit and vegetable intervention improves consumption in a low income population. J Am Diet Assoc 2001;101:195-202.
115. Kretser AJ, Voss T, Kerr WW, Cavadini C, Friedmann J. Effects of two models of nutritional intervention on homebound older adults at nutritional risk. J Am Diet Assoc 2003;103:329-36.
116. Bunout D, Barrera G, de la Maza P, Avendano M, Gattas V, Petermann M, et al. The impact of nutritional supplementation and resistance training on the health functioning of free-living Chilean elders: results of 18 months of follow-up. J Nutr 2001;131:2441S-6S.