Testosterone replacement and the physiologic aspects of aging in men

Mayo Clinic Proceedings

Volumn 75, Issue SUPPL., 2000, Pages

  Morley, John E ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGED; AGING; BODY COMPOSITION; BONE DENSITY; DAILY LIFE ACTIVITY; DRUG EFFECT; EVIDENCE BASED MEDICINE; HORMONE SUBSTITUTION; HUMAN; MALE; MASS SCREENING; MEMORY; METHODOLOGY; MUSCLE ATROPHY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; REVIEW; SAFETY; SEXUAL BEHAVIOR;

ACTIVITIES OF DAILY LIVING; AGED; AGING; BODY COMPOSITION; BONE DENSITY; EVIDENCE-BASED MEDICINE; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MASS SCREENING; MEMORY; MUSCULAR ATROPHY; QUALITY OF LIFE; RESEARCH DESIGN; SAFETY; SEXUAL BEHAVIOR; TESTOSTERONE;

EID: 0033648483     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0025-6196(19)30649-4     Document Type: Article

References (36)

1. Koremann SG, Morley JE, Mooradian AD, et al. Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab. 1990;71:963-969.
2. Wishart JM, Need AG, Horowitz M, Morris HA, Nordin BE. Effect of age on bone density and bone turnover in men. Clin Endocrinol. 1995;42:141-146.
3. Vermeulen A, Deslypere JP. Testicular endocrine function in the ageing male. Maturitas. 1985;7:273-279.
4. Morley JE, Charlton E, Patrick P, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Endocrine Society Abstracts; 1998.
5. Kaiser FE, Morley JE. Gonadotropins, testosterone, and the aging male. Neurobiol Aging. 1994;15:559-563.
6. Morley JE, Kaiser FE, Perry HM 3rd, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism. 1997;46:410-413.
7. Morley JE, Kaiser FE, Impotence: the internist's approach to diagnosis and treatment. Adv Intern Med. 1993;38:151-168.
8. Hajjar RR, Kaiser FE, Morley JE. Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospective analysis. J Clin Endocrinol Metab. 1997;82:3793-3796.
9. Morales A, Johnston B, Heaton JP, Lundie M. Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes. J Urol. 1997; 15:849-854.
10. Powell DM. Profiles in Cognitive Aging. Cambridge, Mass: Harvard University Press; 1994.
11. Flood JF, Fair SA, Kaiser FE, La Regina M, Morley JE. Age-related decrease of plasma testosterone in SAMPS mice: replacement improves age-related impairment of learning and memory. Physiol Behav. 1995;57:669-673.
12. Morley JE, Kaiser F, Raum WJ, et al. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA. 1997;94:7537-7542.
13. Janowsky JS, Oviatt SK, Orwoll ES. Testosterone influences spatial cognition in older men. Behav Neurosci. 1994; 108:325-332.
14. Herbst KL, Anawalt BD, Chemer M, Craft S, Matsumoto AM, Bremner WJ. Testosterone administration improves spatial and verbal memory in normal men. J Int Med. 1999;47:23A.
15. Brown-Sequard CE. The physiological and therapeutic effects of animal testicular extract based on several experiments in man. Physiol Norm Palhol 1989; 115:739-746.
16. Baumgartner RN, Waters DL, Gallagher D, Morley JE, Carry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev. 1999; 107:123-136.
17. Morley JE, Perry HM III, Kaiser FE, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc. 1993;41:149-152.
18. Sih R, Morley JE, Kaiser FE, et al. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. \997$2:1661 -1667.
19. Baumgartner RN, Waters DL, Morley JE, et al. Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat. Metabolism. 1999;48:378-384.
20. Baumgartner RN, Ross RR, Waters DL, et al. Serum leptin in elderly people: associations with sex hormones, insulin, and adipose tissue volumes. Obesity Res. 1999;7:141-149.
21. Perry HM III, Morley JE, Horowitz M, et al. Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism. 1997;46:1399-1405.
22. Paolisso G, Rizzo MR, Mone CM, et al. Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrinol. 1998;48:291-297.
23. Behre HM, Simoni M, Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin Endocrinol. 1997;47:237-240.
24. Miller DK, Carter ME, Miller JP, et al. Inner-city older blacks have high levels of functional disability. J Am Geriatr Soc. 1996;44:1166-1173.
25. Jockenhovel F, Blum WF, Vogel E, et al. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab. 1997;82:2510-13.
26. Morley JE, Alshaher MM, Fair SA, Flood JF, Kumar VB. Leptin and neuropeptide Y modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides. 1999;20:595-600.
27. Morley JE, Perry HM III, Baumgartner RP, Carry PJ. Lepin, adipose tissue and aging: is there a role for testosterone? J Gerontol. 1999;54:B108-B109.
28. Morley JE, Flood JF. Evidence that nitric oxide modulates food intake in mice. Life Sci. 1991;49:707-711.
29. Morley JE, Flood JF. Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice. AmJPhysiol. 1994;266:R164-R168.
30. Jackson JA, Riggs MW, Spiekerman AM. Testosterone deficiency as a risk factor for hip fractures in men: a case-control study. Am J MedSci. 1992;304:4-8.
31. Drinka P, Jaschob K, Schultz S, Rudman D. Is male hip fracture a marker for low testosterone in elderly male nursing home residents? J Am Geriatr Soc. 1993 ;41:192.
32. Abassi AA, Rudman D, Wilson CR, et al. Observations on nursing home residents with a history of hip fracture. Am J Med Sci. 1995;310:229-234.
33. Hartnell J, Korenman SG, Viosca SP. Results of testosterone enanthate therapy in older men. Proc 72nd Ann Meeting Endocrine Soc. 1990:428.
34. Jaffe MD. Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J. 1977;39:1217-1222.
35. Wu S, Weng X. Regulation of atrial natriuretic peptide, thromboxane and prostaglandin production by androgen in elderly men with coronary heart disease. Chin Med Sei J. 1993;8:207-209.
36. Morley JE, Kaiser FE, Sih R, Hajjar R, Perry HM III. Testosterone and frailty. Clin Geriatr Med. 1997;13:685-695.