Carbazates as potent inhibitors of hormone-sensitive lipase

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1741-1744

  De Jong, Johannes C ^a   Sørensen, Lotte G ^a   Tornqvist, Hans ^a   Jacobsen, Poul ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Carbazates; Hormone sensitive lipase; Inhibition

Indexed keywords

CARBAZIC ACID DERIVATIVE; TRIACYLGLYCEROL LIPASE;

ARTICLE; CATALYST; DIABETIC OBESITY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITOR INTERACTION; FATTY ACID METABOLISM; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE;

CHOLESTEROL ESTERASE; ENZYME INHIBITORS; HYDRAZINES;

EID: 1542404606     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.038     Document Type: Article

References (20)

1. Unger R.H. Diabetes. 44:1995;863.
2. Boden G. Diabetes. 46:1997;3.
3. Mulder H., Holst L.S., Svensson H., Sundler F., Ahrén B., Rorsman P., Holm C. Diabetes. 48:1999;228.
4. Prentki M., Corkey B.E. Diabetes. 45:1996;273.
5. Frayn K.N., Williams C.M., Arner P. Clinical Science. 90:1996;243.
6. Fredrikson G., Tornqvist H., Belfrage P. Biochim. Biophys. Acta. 876:1986;288.
7. Holm C., Osterlund T., Laurell H., Contreras J.A. Annu. Rev. Nutr. 20:2000;365.
8. Feaster S.R., Lee K., Baker N., Hui D.Y., Quinn D.M. Biochemistry. 35:1996;16723.
9. Tornqvist H., Krabisch L., Belfrage P. J. Lipid Res. 15:1974;291.
10. For a detailed description of the assays see: Beltrandel-Rio, H.; Jacobsen, P.; de Jong, J. C. WO Patent 01/87843, 2001; Chem. Abstr. 2001, 135, 371653.
11. Contreras J.A., Danielsson B., Johansson C., Osterlund T., Langin D., Holm C. Protein Expr. Purif. 12:1998;93.
12. Gade T., Streek M., Voss J. Chem. Ber. 125:1992;127.
13. Laurenco C., Villien L., Kaufmann G. Tetrahedron. 40:1984;2731.
14. Höft E., Rieche A. Angew. Chem. 73:1961;807.
15. Carpino L.A. J. Org. Chem. 30:1965;321.
16. Sakane K., Terayama K.I., Haruki E., Otsuji Y., Imoto E. Bull. Chem. Soc. Jpn. 47:1974;1297.
17. Biel J.H., Drukker A.E., Mitchell T.F., Sprengeler E.P., Nuhfer P.A., Conway A.C., Horita A. J. Am. Chem. Soc. 81:1959;2805.
18. Hajós Gy., Messmer A. J. Heterocycl. Chem. 15:1978;463.
19. Biel J.H., Drukker A.E., Mitchell T.F. Jr. J. Am. Chem. Soc. 82:1960;2204.
20. 3-(3,5-dimethoxy-4-formylphenoxy)propanoyl aminomethyl resin (2% DVB, 0.62 mmol/g), Kilburn, J. P. Novel solid phase synthesis strategies for the preparation of heterocycles and guanidines, PhD Thesis, Open University, 2002, p 48.