The role of p53 in cell cycle regulation

Pathology Research and Practice

Volumn 192, Issue 7, 1996, Pages 669-675

  Shaw, Phillip H ^a  

^a UNIVERSITY INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Apoptosis; CDIs; CDKs; P21(WAF1 CIP1 Sdi1); P53

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE; PROTEIN P21; PROTEIN P53;

APOPTOSIS; CELL CYCLE; CELL CYCLE S PHASE; DOWN REGULATION; ETIOLOGY; HUMAN; PROTEIN EXPRESSION; REVIEW; TRANSCRIPTION REGULATION; TUMOR CELL; TUMOR SUPPRESSOR GENE;

EID: 0029742383     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0344-0338(96)80088-4     Document Type: Article

References (75)

1. Aboussekhra A, Biggerstaff M, Shivji M, Vilpo J, Podust V, Protic M, Hubscher U, Egly J, Wood R (1995) Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80: 859
2. Albino AP, Shea CR, McNutt NS (1992) Oncogenes in melanomas. J Dermatol 19: 853
3. Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, van Tuinen P, Ledbetter DH, Barker DF, Nakamura Y (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217
4. Bargonetti J, Manfredi JJ, Chen X, Marshak DR, Prives C (1993) A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes and Development 7: 2565
5. Buckbinder L, Talbott R, Seizinger BR, Kley N (1994) Gene regulation by temperature-sensitive p53 mutants: Identification of p53 response genes. Proc. Nad. Acad. Sci. USA 91: 10640
6. Caldas C, Hahn S, da Costa A, Redston M, Schutte M, Seymour A, Weinstein C, Hruban R, Yeo C, Kern S (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genetics 8: 27
7. Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994) Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations. Science 265: 346
8. Coleman WB, Grisham JW, Smith GJ (1994) Morphologic transformation of the C3H 10T1/2 cell line is accompanied by altered expression of the p53 tumor suppressor gene, Carcinogenesis 15: 145
9. Dameron KM, Volpert OV, Tainsky MA, Bouck N (1994) Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265: 1582
10. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery, Jr. CA, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215
11. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013
12. El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B (1992) Definition of a consensus binding site for p53. Nat Genet 1: 45
13. El-Deiry WS, Tokino T, Velculescu V, Levy DB, Parsons R, Trent J, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a Potential Medicator of p53 Tumor Suppression. Cell 75: 817
14. Ewen M, Oliver C, Sluss H, Miller S, Peeper D (1995) p53-Dependent repression of CDK4 translation in TGF-b-induced G1 cell-cycle arrest. Genes and Development 9: 204
15. Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C (1992) Wild-type p53 activates transcription in vitro [see comments]. Nature 358: 83
16. Fields S, Jang SK (1990) Presence of a potent transcription activating sequence in the p53 protein. Science 249: 1046
17. Funk WD, Pak DT, Karas RH, Wright WE, Shay JW (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12: 2866
18. Gerken SC, Albertsen H, Elsner T, Ballard L, Holik P, Lawrence E, Moore M, Zhao X, White R (1995) A strategy for constructing high-resolution genetic maps of the human genome: A genetic map of chromosome 17p, ordered with meiotic breakpoint-mapping panels. Am J Hum Genet 56: 484
19. Ginsberg D, Mechta F, Yaniv M, Oren M (1991) Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad. Sci U.S.A. 88: 9979
20. Ginsberg D, Mechta F, Yaniv M, Oren M (1991) Wild-type p53 can down-modulate the activity of various promoters. Proc. Natl. Acad. Sci. U.S.A. 88: 9979
21. Girard F, Strausfeld U, Fernandez A, Lamb N (1991) Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169
22. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge S (1993) The p21 Cdk-interacting Protein Cip1 is a potent Inhibitor if G1 Cyclin-Dependent Kinases. Cell 75: 805
23. Hinds P, Weinberg R (1994) Tumor suppresor genes. Curr. Opin. Genet. Dev. 4: 135
24. Horikoshi N, Usheva A, Chen J, Levine AJ, Weinmann R, Shenk T (1995) Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol. Cell. Biol. 25: 227
25. Hunter T (1993) Braking the Cycle. Cell 75: 839
26. Hupp T, Lane D (1994) Regulation of the cryptic sequence-specific DNA binding function of p53 by protein kinases. Cold Spring Harb. Symp. Quant. Biol. (in press)
27. Hussussian C, Struewing J, Goldstein A, Higgins P, Ally D, Sheanhan D, Clark W, Tucker M, Dracopoli N (1994) Germaline p16 mutations in familial melanoma. Nature Genet. 8: 15
28. Jeffrey PD, Gorina S, Pavletich NP (1995) Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science 267: 1498
29. Jen T, Harper J, Bigner S, Bigner D, Papdopuolos N, Markowitz S, Willson J, Kinzer K, Vogelstein B (1994) Deletion of p16 and p15 in brain tumors. Cancer Research 54: 6353
30. Jiang H, Lin J, Su Z, Collart FR, Huberman E, Fisher PB (1994) Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene 9: 3397
31. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304
32. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett, BS, Vogelstein B, Fornace, Jr. AJ (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587
33. Kuerbitz S, Plunkett B, Walsh W, Kastan MB (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad. Sci U.S.A. 89: 7491
34. Lane D, Crawford L (1979) T-antigen is bound to host protein in SV40-transformed cells. Nature 278: 261
35. Lane DP (1992) Cancer: p53, guardian of the genome. Nature 358: 15
36. Lew DJ, Reed SI (1995) Cell cycle control of morphogenesis in budding yeast. Curr. Opin. Genet. Dev. 5: 17
37. Linzer D, Levine A (1979) Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17: 43
38. Lo K, Huang D, Lau K (1995) p16 gene alterations in Nasopharyngeal carcinoma. Cancer Research 55: 2039
39. Lu X, Lane DP (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes. Cell 75: 765
40. Martinez J, Georgoff I, Levine AJ (1991) Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev. 5: 151
41. Matlashewski G, Lamb P, Pim D, Peacock J, Crawford L, Benchimol S (1984) Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. EMBO J 3: 3257
42. Merlo GR, Basolo F, Fiore L, Duboc L, Hynes NE (1995) p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin. J Cell Biol. 128: 1185
43. Meyerson M, Enders GH, Wu, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992) A family of human cdc2-related protein kinases. EMBO J 11: 2909
44. Miyashita T, Harigai M, Hanada M, Reed J (1994) Identification of a p53-dependent negative response element in the Bcl-2-gene. Cancer Research 54: 3131
45. Miyashita T, Harigai M, Hanada M, Reed JC (1994) Identification of a p53-dependent negative response element in bcl-2-gene. Cancer Res 54: 3131
46. Miyashita T, Reed J (1995) Tumor Suppressor p53 is a Direct Transcriptional Activator of the Human bax Gene. Cell 80: 293
47. Momand J, Zambetti GP, Olson DC, George D, Levine AJ (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237
48. Nigg EA (1993) Cellular substrates of p34 cdc2 and its companion cyclin-dependent kinases. Curr. Opin. Cell Biol. 5: 187
49. Nigro JM, Baker SJ, Presinger AC, Jessup JM, Hostetter R, Clearly K, Bigner SH, Davidson N, Baylin S, Devilee P, et al. (1989) Mutations in the p53 gene occur in diverse human tumour types. Nature 342: 705
50. Noda A, Ning Y, Venable S, Pereira-Smith O, Smith JR (1994) Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen. Exp. Cell Res. 211: 90
51. Nurse P (1990) Universal control mechanism regulating onset of M-phase. Nature 344: 503
52. Okamoto K, Beach D (1994) Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J. 13: 4816
53. Oliner JD, Kanzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas [see comments]. Nature 358: 80
54. Oltvai Z, Milliman C, Korsmeyer S (1993) BCL-2 Heterodimerizes in Vivo with a Conserved Homolog, Bax, That Accelerates Programed Cell Death. Cell 74: 609
55. Pavletich NP, Chambers KA, Pabo CO (1993) The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes and Development 7: 2556
56. kip1, a Cyclin dependent kinase inhibitor and a potential mediator of extracellular anti-mitogenic signals. Cell 78: 59
57. Raycroft L, Wu HY, Lozano G (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249: 1049
58. Reed SI (1992) The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8: 529
59. Scharer E, Iggo R (1992) Mammalian p53 can function as a transcription factor in yeast. Nucleic. Acids. Res. 20: 1539
60. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Nad. Acad. Sci. U.S.A. 89: 4495
61. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73: 1059
62. Sherr CJ (1996) Mammalian G1 cyclins. Cell 73: 1059
63. Shivji M, Grey S, Strausfeld U, Wood R, Blow J (1994) CIP1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4: 1062
64. Singh S, Simon M, Meybohm I, Jantke I, Jonat W, Maass H, Goedde HW (1993) Human breast cancer: frequent p53 allele loss and protein overexpression. Hum. Genet. 90: 635
65. Tokino T, Thiagalingam S, El-Deiry WS, Waldman T, Kinzler KW, Vogelstein B (1994) p53 tagged sites from human genomic DNA. Hum Mol Genet 3: 1537
66. Toyoshima H, Hunter T (1994) p27, A novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21. Cell 78: 67
67. Tsujimoto Y, Croce C (1986) Analysis of the structure, transcripts and protein products of Bcl-2, the gene involved in human follicular lymphoma. Proc Nad Acad Sci U.S.A. 83: 5214
68. Waga S, Hannon G, Beach D, Stillman B (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574
69. Wang Y,Reed M, Wang P, Stenger JE, Mayr G, Anderson ME, Schwedes JE, Tegtmeyer P (1993) p53 domains: Identification and characterization of two autonomous DNA-binding regions. Genes and Development 7: 2575
70. Xiong Y, Menninger J, Beach D, Ward D (1995) Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 13: 575
71. Xiong Y, Zhang H, Beach D (1993) Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes and Development 7: 1572
72. Yamarnoto M, Yoshida M, Ono K, Fujita T, Ohtawi-Fujita N, Sakai T, Nikaido T (1995) Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 and normal p53 suppresses Cyclin A expression. Exp Cell Res 210: 94
73. Yonish-Rouach E, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ, May P, Oren M (1993) p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol 13: 1415
74. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345
75. Zauberman A, Lupo A, Oren M (1995) Identification of p53 target genes through immune selection of genomic DNA - The cyclin G gene contains two distinct p53 binding sites. Oncogene 10: 2361