Homer-3 regulates activation of serum response element in T cells via its EVH1 domain

Blood

Volumn 103, Issue 6, 2004, Pages 2248-2256

  Ishiguro, Kazuhiro ^a   Xavier, Ramnik ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CCAAT ENHANCER BINDING PROTEIN BETA; CD28 ANTIGEN; CD3 ANTIGEN; ENABLED VASODILATOR STIMULATED PHOSPHOPROTEIN HOMOLOGY 1 PROTEIN; HOMER 3 PROTEIN; PHORBOL ESTER; PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 1542373652     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-08-2671     Document Type: Article

References (64)

1. Khan AA, Bose C, Yam LS, et al. Physiological regulation of the immunological synapse by agrin. Science. 2001;292:1681-1686.
2. Harder T, Simons K. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lmphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur J Immunol. 1999;29:556-562.
3. Shaw AS, Allen PM. Kissing cousins: immunological and neurological synapses. Nat Immunol. 2001;2:575-576.
4. Davis SJ, Ikemizu S, Evans EJ, et al. The nature of molecular recognition by T cells. Nat Immunol. 2003;4:217-224.
5. Horejsi VV. The roles of membrane microdomains (rafts) in T cell activation. Immunol Rev. 2003; 191:148-164.
6. Renfranz PJ, Beckerle MC. Doing (F/L)PPPPs: EVH1 domains and their proline-rich partners in cell polarity and migration. Curr Opin Cell Biol. 2002;14:88-103.
7. Bear JE, Krause M, Gertler FB. Regulating cellular actin assembly. Curr Opin Cell Biol. 2001;13: 158-166.
8. Reinhard M, Jarchau T, Walter U. Actin-based motility: stop and go with Ena/VASP proteins. Trends Biochem Sci. 2001;26:243-249.
9. Krause M, Bear JE, Loureiro JJ, et al. The Ena/VASP enigma. J Cell Sci. 2002;115:4721-4726.
10. Derry JM, Ochs HD, Francke U. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell. 1994;78:635-644.
11. Caron E. Regulation of Wiskott-Aldrich syndrome protein and related molecules. Curr Opin Cell Biol. 2002;14:82-87.
12. Cooper JA, Schafer DA. Control of actin assembly and disassembly at filament ends. Curr Opin Cell Biol. 2000;12:97-103.
13. Wakioka T, Sasaki A, Kato R, et al. Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001;412:647-651.
14. Brakeman PR, Lanahan AA, O'Brien R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386: 284-288.
15. Kato A, Ozawa F, Saitoh Y, et al. vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. FEBS Lett. 1997;412:183-189.
16. Tu JC, Xiao B, Yuan JP, et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21:717-726.
17. Kato A, Ozawa F, Saitoh Y, et al. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J Biol Chem. 1998;273:23969-23975.
18. Tu JC, Xiao B, Naisbitt S, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23:583-592.
19. Barzik M, Carl UD, Schubert WD, et al. The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. J Mol Biol. 2001;309:155-169.
20. Niebuhr K, Ebel F, Frank R, et al. A novel prolinerich motif present in Acta of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J. 1997;16:5433-5444.
21. Carl UD, Pollmann M, Orr E, et al. Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands. Curr Biol. 1999;9:715-718.
22. Xiao B, Tu JC, Petralia RS, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998; 21:707-716.
23. Shiraishi Y, Mizutani A, Bito H, et al. Cupidin, an isoform of HomerNesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J Neurosci. 1999;19: 8389-8400.
24. Tadokoro S, Tachibana T, Imanaka T, et al. Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering. Proc Natl Acad Sci U S A. 1999;96:13801-13806.
25. Fagni L, Worley PF, Ango F. Homer as both a scaffold and transduction molecule (review). Sci STKE. 2002;2002:RE8.
26. Gertler FB, Niebuhr K, Reinhard M, et al. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996;87:227-239.
27. Cannon JL, Labno CM, Bosco G, et al. Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation. Immunity. 2001;15:249-259.
28. Badour K, Zhang J, Shi F, et al. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity. 2003;18:141-154.
29. Gray NW, Fourgeaud L, Huang B, et al. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr Biol. 2003;13:510-515.
30. Foa L, Rajan I, Haas K, et al. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo. Nat Neurosci. 2001;4:499-506.
31. Yuan JP, Kiselyov K, Shin DM, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-789.
32. Kato A, Fukuda T, Fukazawa Y, et al. Phorbol esters promote postsynaptic accumulation of Vesl-1S/Homer-1a protein. Eur J Neurosci. 2001;13: 1292-1302.
33. Shin DM, Dehoff M, Luo X, et al. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLC{beta} GAP activities. J Cell Biol. 2003;162:293-303.
34. Schultz J, Copley RR, Doerks T, et al. SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res. 2000;28:231-234.
35. Soloviev MM, Ciruela F, Chan WY, et al. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. J Mol Biol. 2000;295:1185-1200.
36. Khokhlatchev A, Rabizadeh S, Xavier R, et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002;12:253-265.
37. Rohatgi R, Ma L, Miki H, et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999;97:221-231.
38. Maytin EV, Lin JC, Krishnamurthy R, et al. Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Dev Biol. 1999;216:164-181.
39. Henry DO, Moskalenko SA, Kaur KJ, et al. Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB. Mol Cell Biol. 2000;20:8064-8092.
40. Roumier A, Olivo-Marin JC, Arpin M, et al. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity. 2001;15:715-728.
41. Bunnell SC, Kapoor V, Trible RP, et al. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity. 2001;14:315-329.
42. Schreiber E, Matthias P, Muller MM, et al. Rapid detection of octamer binding proteins with 'miniextracts', prepared from a small number of cells. Nucleic Acids Res. 1989;17:6419.
43. Brummelkamp TR, Bernards R, Agami R. Asystem for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296: 550-553.
44. Moores SL, Selfors LM, Fredericks J, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000;20:6364-6373.
45. Sancho D, Montoya MC, Monjas A, et al. TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion. J Immunol. 2002;169:292-300.
46. Penninger JM, Crabtree GR. The actin cytoskeleton and lymphocyte activation. Cell. 1999;96:9-12.
47. Bunnell SC, Hong DI, Kardon JR, et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol. 2002;158:1263-1275.
48. Lee G, Gilman M. Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells. Mol Cell Biol. 1994;14:4579-4587.
49. Charvet C, Auberger P, Tartare-Deckert S, et al. Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway. J Biol Chem. 2002;277:15376-15384.
50. Genot E, Cantrell DA. Ras regulation and function in lymphocytes. Curr Opin Immunol. 2000;12: 289-294.
51. Tognon CE, Kirk HE, Passmore LA, et al. Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol Cell Biol. 1998;18:6995-7008.
52. Hanlon M, Sealy L. Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta. J Biol Chem. 1999;274: 14224-14228.
53. Soh JW, Lee EH, Prywes R, et al. Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element. Mol Cell Biol. 1999;19:1313-1324.
54. Norman C, Runswick M, Pollock R, et al. Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell. 1988;55:989-1003.
55. Shaw PE, Schroter H, Nordheim A. The ability of a temary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter. Cell. 1989;56:563-572.
56. Akira S, Isshiki H, Sugita T, et al. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 1990;9:1897-1906.
57. Descombes P, Chojkier M, Lichtsteiner S, et al. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 1990;4:1541-1551.
58. Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell. 1991;67:569-579.
59. Syder AJ, Yu QC, Paller AS, et al. Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis: correlation between location and disease severity. J Clin Invest. 1994;93:1533-1542.
60. Treisman R. Journey to the surface of the cell: Fos regulation and the SRE. EMBO J. 1995;14: 4905-4913.
61. Hanlon M, Bundy LM, Sealy L. C/EBP beta and Elk-1 synergistically transactivate the c-fos serum response element. BMC Cell Biol. 2000;1:2.
62. Hsueh YP, Wang TF, Yang FC, et al. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature. 2000;404:298-302.
63. Sheng H, Shao J, Williams CS, et al. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis. 1998;19:543-549.
64. Deisseroth K, Mermelstein PG, Xia H, et al. Signaling from synapse to nucleus: the logic behind the mechanisms. Curr Opin Neurobiol. 2003;13: 354-365.