Actin-based motility: Stop and go with Ena/VASP proteins

Trends in Biochemical Sciences

Volumn 26, Issue 4, 2001, Pages 243-249

  Reinhard, Matthias ^a   Jarchau, Thomas ^a   Walter, Ulrich ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BINDING PROTEIN; CYCLIC NUCLEOTIDE; ENABLED STIMULATED PHOSPHOPROTEIN; INTEGRIN; PHOSPHOPROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; CELL ADHESION; CELL MIGRATION; CYTOTOXICITY; LISTERIA; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SEQUENCE HOMOLOGY; THROMBOCYTE FUNCTION;

ACTINS; ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; DNA-BINDING PROTEINS; MICROFILAMENT PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION;

ENA; EUKARYOTA; LISTERIA; POSIBACTERIA;

EID: 0035312298     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01785-0     Document Type: Review

References (50)

1. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility
2. Molecular cloning, structural analysis and functional expression of the proline-rich focal adhesion and microfilament-associated protein VASP
3. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
4. VASP
5. Putting on the brakes: A negative regulatory function for Ena/VASP proteins in cell migration
6. Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein
7. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function
8. Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice
9. Mena is required for neurulation and commissure formation
10. PKA phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3-domains
11. Structure of the enabled/VASP homology 1 domain-peptide complex: A key component in the spatial control of actin assembly
12. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function
13. Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity
14. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family
15. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the Enabled/Vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyterminal zyxin-like domain
16. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
17. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
18. Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains
19. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled
20. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins
21. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation
22. Directed actin polymerization is the driving force for epithelial cell-cell adhesion
23. Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled
24. VASP dynamics during lamellipodia protrusion
25. Negative regulation of fibroblast motility by Ena/VASP proteins
26. The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins
27. Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated phosphoprotein family of proteins
28. Arrest of Listeria movement in host cells by a bacterial ActA analogue: Implications for actin-based motility
29. Secrets of actin-based motility revealed by a bacterial pathogen
30. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
31. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes
32. Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP
33. Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) regulates its interaction with actin
34. Actin machinery: Pushing the envelope
35. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans
36. cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets
37. Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I
38. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
39. From membrane to cytoskeleton: Enabling a connection
40. From the growth cone surface to the cytoskeleton: One journey, many paths
41. Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance
42. The tyrosine kinase Abl and its substrate Enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
43. Adhesion in cell migration
44. Molecular tinkering of G protein-coupled receptors: An evolutionary success
45. Signal transduction underlying growth cone guidance by diffusible factors
46. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity
47. The interaction of the cell-contact proteins VASP and vinculin is regulated by phosphatidylinositol-4,5-bisphosphate
48. Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands
49. 3 peptide from VASP overcomes the inhibition of actin nucleation by profilin II and thymosin β4
50. The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences