Regulation of Wiskott-Aldrich syndrome protein and related molecules

Current Opinion in Cell Biology

Volumn 14, Issue 1, 2002, Pages 82-87

  Caron, Emmanuelle ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

WISKOTT ALDRICH SYNDROME PROTEIN;

CYTOSKELETON; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; WISKOTT ALDRICH SYNDROME;

VESPIDAE;

EID: 0036468733     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(01)00298-8     Document Type: Review

References (55)

1. The Wiskott-Aldrich syndrome protein (WASP): Roles in signaling and cytoskeletal organization
2. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
3. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
4. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
5. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
6. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP
7. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
8. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
9. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
10. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
11. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
12. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
13. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate
14. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
15. Profilin enhances Cdc42-induced nucleation of actin polymerization
16. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
17. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
18. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
19. Requirement of the basic region of N-WASP/WAVE2 for actin-based motility
20. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
21. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
22. Tyrosine phosphorylation regulates the SH3 mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein
23. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42
24. Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases
25. WIP regulates N-WASP-mediated actin polymerization and filopodium formation
26. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
27. Characterization of TCL, a new GTPase of the rho family related to TC10 and Cdc42
28. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation
29. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome
30. Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages
31. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
32. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
33. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3
34. Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
35. Wasp recruitment to the Tcell:APC contact site occurs independently of Cdc42 activation
36. Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells
37. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development
38. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac
39. Actin-based motility of pathogens: The Arp2/3 complex is a central player
40. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
41. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells
42. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
43. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation
44. Collagen induces tyrosine phosphorylation of Wiskott-Aldrich syndrome protein in human platelets
45. Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42
46. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
47. Abp1p and cortactin, new 'hand-holds' for actin
48. Yeast Eps15-like endocytic protein, Pan1p, activates the Arp2/3 complex
49. Signaling to actin dynamics
50. Structure of Arp2/3 complex in its activated state and in actin filament branch junctions
51. AWASp-VASP complex regulates actin polymerization at the plasma membrane
52. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family
53. Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP
54. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
55. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex