Systematic Mutagenesis of the Leucine-rich Repeat (LRR) Domain of CCR4 Reveals Specific Sites for Binding to CAF1 and A Separate Critical Role for the LRR in CCR4 Deadenylase Activity

Journal of Biological Chemistry

Volumn 279, Issue 14, 2004, Pages 13616-13623

  Clark, Lisa B ^a   Viswanathan, Palaniswamy ^a   Quigley, Gloria ^a   Chiang, Yueh Chin ^a   McMahon, Jeffrey S ^a   Yao, Gang ^a   Chen, Junji ^a   Nelsbach, Andreas ^a   Denis, Clyde L ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; ENZYME KINETICS; ENZYMES; MOLECULAR STRUCTURE; RNA;

LEUCINE RICH REPEAT (LRR) DOMAINS; MULTIPROTEINS;

MUTAGENESIS;

CCR4 DEADENYLASE; EXODEOXYRIBONUCLEASE III; LEUCINE; LIGAND; MESSENGER RNA; POLYADENYLIC ACID DEADENYLASE; PROTEIN CAF1; PROTEIN CAF16; PROTEIN CCR4; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; IMMUNOPRECIPITATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RNA DEGRADATION; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; ENZYME ACTIVATION; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RIBONUCLEASES; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 1542323792     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313202200     Document Type: Article

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