Histone H3-K9 Methyltransferase ESET Is Essential for Early Development

Molecular and Cellular Biology

Volumn 24, Issue 6, 2004, Pages 2478-2486

  Dodge, Jonathan E ^a   Kang, Yong Kook ^a,b   Beppu, Hideyuki ^a   Lei, Hong ^a,c   Li, En ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H3; LYSINE; MELANOMA ANTIGEN; METHYLTRANSFERASE; METHYLTRANSFERASE ESET; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; BLASTOCYST; CATALYSIS; CATALYST; CELL SURVIVAL; CHROMOSOME ABERRATION; DNA METHYLATION; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; EUCHROMATIN; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; HETEROCHROMATIN; INNER CELL MASS; KNOCKOUT MOUSE; LYMPHOMA; MOUSE; NIDATION; NONHUMAN; OOCYTE; PRADER WILLI SYNDROME; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN METHYLATION; ZYGOTE;

ANIMALS; BASE SEQUENCE; BLASTOCYST; CELL LINE; CELL SURVIVAL; DNA METHYLATION; DNA, COMPLEMENTARY; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; METHYLTRANSFERASES; MICE; MICE, KNOCKOUT; PHENOTYPE; PREGNANCY;

ANIMALIA; MAMMALIA;

EID: 1542314243     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.6.2478-2486.2004     Document Type: Article

References (32)

1. Beard, C., E. Li, and R. Jaenisch. 1995. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 9:2325-2334.
2. Bourc'his, D., G. L. Xu, C. S. Lin, B. Bollman, and T. H. Bestor. 2001. Dnmt3L and the establishment of maternal genomic imprints. Science 294:2536-2539.
3. Dodge, J. E., A. F. List, and B. W. Futscher. 1998. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia. Int. J. Cancer 78:561-567.
4. Donohoe, M. E., X. Zhang, L. McGinnis, J. Biggers, E. Li, and Y. Shi. 1999. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol. Cell. Biol. 19:7237-7244.
5. Gaudet, F., J. G. Hodgson, A. Eden, L. Jackson-Grusby, J. Dausman, J. W. Gray, H. Leonhardt, and R. Jaenisch. 2003. Induction of tumors in mice by genomic hypomethylation. Science 300:489-492.
6. Hata, K., M. Okano, H. Lei, and E. Li. 2002. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129:1983-1993.
7. Jackson, J. P., A. M. Lindroth, X. Cao, and S. E. Jacobsen. 2002. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416:556-560.
8. Jaenisch, R., and A. Bird. 2003. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33(Suppl.):245-254.
9. Kang, Y. K., J. S. Park, C. S. Lee, Y. I. Yeom, A. S. Chung, and K. K. Lee. 1999. Efficient integration of short interspersed element-flanked foreign DNA via homologous recombination. J. Biol. Chem. 274:36585-36591.
10. Lagger, G., D. O'Carroll, M. Rembold, H. Khier, J. Tischler, G. Weitzer, B. Schuettengruber, C. Hauser, R. Brunmeir, T. Jenuwein, and C. Seiser. 2002. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 21:2672-2681.
11. Lane, N., W. Dean, S. Erhardt, P. Hajkova, A. Surani, J. Walter, and W. Reik. 2003. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35:88-93.
12. Lehnertz, B., Y. Ueda, A. A. Derijck, U. Braunschweig, L. Perez-Burgos, S. Kubicek, T. Chen, E. Li, T. Jenuwein, and A. H. Peters. 2003. Suv39h-mediated histone h3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13:1192-1200.
13. Li, E. 2002. Chromatin modification and epigenetic reprogramming in mammalian development. Nat. Rev. Genet. 3:662-673.
14. Li, E., C. Beard, and R. Jaenisch. 1993. Role for DNA methylation in genomic imprinting. Nature 366:362-365.
15. Li, E., T. H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926.
16. Mountford, P., B. Zevnik, A. Duwel, J. Nichols, M. Li, C. Dani, M. Robertson, I. Chambers, and A. Smith. 1994. Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl. Acad. Sci. USA 91:4303-4307.
17. Nichols, J., B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius, I. Chambers, H. Scholer, and A. Smith. 1998. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391.
18. O'Carroll, D., S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein. 2001. The Polycomb-group gene Ezh2 is required for early mouse development. Mol. Cell. Biol. 21:4330-4336.
19. O'Carroll, D., H. Scherthan, A. H. Peters, S. Opravil, A. R. Haynes, G. Laible, S. Rea, M. Schmid, A. Lebersorger, M. Jerratsch, L. Sattler, M. G. Mattei, P. Denny, S. D. Brown, D. Schweizer, and T. Jenuwein. 2000. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol. Cell. Biol. 20:9423-9433.
20. 0 cells. Science 296:1132-1136.
21. Okano, M., D. W. Bell, D. A. Haber, and E. Li. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247-257.
22. Rea, S., F. Eisenhaber, D. O'Carroll, B. D. Strahl, Z. W. Sun, M. Schmid, S. Opravil, K. Mechtler, C. P. Ponting, C. D. Allis, and T. Jenuwein. 2000. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406:593-599.
23. Schultz, D. C., K. Ayyanathan, D. Negorev, G. G. Maul, and F. J. Rauscher. 2002. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16:919-932.
24. Surani, A., and A. Smith. 2003. Differentiation and gene regulation. Programming, reprogramming and regeneration. Curr. Opin. Genet. Dev. 13:445-447.
25. Tachibana, M., K. Sugimoto, T. Fukushima, and Y. Shinkai. 2001. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276:25309-25317.
26. Tachibana, M., K. Sugimoto, M. Nozaki, J. Ueda, T. Ohta, M. Ohki, M. Fukuda, N. Takeda, H. Niida, H. Kato, and Y. Shinkai. 2002. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16:1779-1791.
27. Tamaru, H., and E. U. Selker. 2001. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414:277-283.
28. Tamaru, H., X. Zhang, D. McMillen, P. B. Singh, J. Nakayama, S. I. Grewal, C. D. Allis, X. Cheng, and E. U. Selker. 2003. Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat. Genet. 34:75-79.
29. Wang, H., W. An, R. Cao, L. Xia, H. Erdjument-Bromage, B. Chatton, P. Tempst, R. G. Roeder, and Y. Zhang. 2003. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12:475-487.
30. Xin, Z., M. Tachibana, M. Guggiari, E. Heard, Y. Shinkal, and J. Wagstaff. 2003. Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. J. Biol. Chem. 278:14996-15000.
31. Yang, L., L. Xia, D. Y. Wu, H. Wang, H. A. Chansky, W. H. Schubach, D. D. Hickstein, and Y. Zhang. 2002. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21:148-152.
32. Zhang, Y., and D. Reinberg. 2001. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 15:2343-2360.