-
1
-
-
0029025471
-
Gender as a risk factor for adverse events to medications
-
Kando JC, Yonkers KA, Cole JO. Gender as a risk factor for adverse events to medications. Drugs 1995; 50: 1-6.
-
(1995)
Drugs
, vol.50
, pp. 1-6
-
-
Kando, J.C.1
Yonkers, K.A.2
Cole, J.O.3
-
2
-
-
0036219472
-
Trends of OC use 1980-99 in a German cohort of women
-
Heinemann K, Moehner S, Lewis M, Assmann A, Garbe E, Heinemann LA. Trends of OC use 1980-99 in a German cohort of women. Zentralbl Gynakol 2002; 124: 128-31.
-
(2002)
Zentralbl Gynakol
, vol.124
, pp. 128-131
-
-
Heinemann, K.1
Moehner, S.2
Lewis, M.3
Assmann, A.4
Garbe, E.5
Heinemann, L.A.6
-
3
-
-
0036642493
-
Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy
-
Wit FW, Weverling GJ, Weel J, Jurriaans S, Lange JM. Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy. J Infect Dis 2002; 186: 23-31.
-
(2002)
J Infect Dis
, vol.186
, pp. 23-31
-
-
Wit, F.W.1
Weverling, G.J.2
Weel, J.3
Jurriaans, S.4
Lange, J.M.5
-
4
-
-
0033587510
-
Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions
-
Lucas GM, Chaisson RE, Moore RD. Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions. Ann Intern Med 1999; 131: 81-7.
-
(1999)
Ann Intern Med
, vol.131
, pp. 81-87
-
-
Lucas, G.M.1
Chaisson, R.E.2
Moore, R.D.3
-
5
-
-
1542267951
-
Use of HAART in women: Similar response but greater toxicity. XIV
-
Barcelona: Abstract WePeB5968
-
Nguyen ML, Nagy GS, Hernandez I, Holtzberg J, Del Rio C, Lennox J.Use of HAART in women: similar response but greater toxicity. XIV. International AIDS Conference, Barcelona 2002: Abstract WePeB5968.
-
(2002)
International AIDS Conference
-
-
Nguyen, M.L.1
Nagy, G.S.2
Hernandez, I.3
Holtzberg, J.4
Del Rio, C.5
Lennox, J.6
-
6
-
-
12944265462
-
Incidence of adverse reactions in HIV patients treated with protease inhibitors: A cohort study
-
Bonfanti P, Valsecchi L, Parazzini F et al. Incidence of adverse reactions in HIV patients treated with protease inhibitors: a cohort study. J Acquir Immune Defic Syndr 2000; 23: 236-45.
-
(2000)
J Acquir Immune Defic Syndr
, vol.23
, pp. 236-245
-
-
Bonfanti, P.1
Valsecchi, L.2
Parazzini, F.3
-
7
-
-
0033770918
-
Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation
-
Palovaara S, Kivisto KT, Tapanainen P, Manninen P, Jeuvonen PJ, Laine K. Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1′-hydroxylation. Br J Clin Pharmacol 2000; 50: 333-7.
-
(2000)
Br J Clin Pharmacol
, vol.50
, pp. 333-337
-
-
Palovaara, S.1
Kivisto, K.T.2
Tapanainen, P.3
Manninen, P.4
Jeuvonen, P.J.5
Laine, K.6
-
8
-
-
0032411566
-
Can oral contraceptive steroids influence the elimination of nifedipine and its primary pyridine metabolite in humans?
-
Balogh A, Gessinger S, Svarovsky U et al. Can oral contraceptive steroids influence the elimination of nifedipine and its primary pyridine metabolite in humans? Eur J Clin Pharmacol 1998; 54: 729-34.
-
(1998)
Eur J Clin Pharmacol
, vol.54
, pp. 729-734
-
-
Balogh, A.1
Gessinger, S.2
Svarovsky, U.3
-
9
-
-
0023134932
-
Oral contraceptive interaction with cyclosporin
-
Deray G, le Hoang P, Cacoub P, Assogba U, Grippon P, Baumelou A. Oral contraceptive interaction with cyclosporin. Lancet 1987; 1: 158-9.
-
(1987)
Lancet
, vol.1
, pp. 158-159
-
-
Deray, G.1
Le Hoang, P.2
Cacoub, P.3
Assogba, U.4
Grippon, P.5
Baumelou, A.6
-
10
-
-
0022645413
-
Impairment of prednisolone disposition in women taking oral contraceptives of conjugated estrogens
-
Gustavson LE, Legler UF, Benet LZ. Impairment of prednisolone disposition in women taking oral contraceptives of conjugated estrogens. J Clin Endocrinol Metab 1986; 62: 234-7.
-
(1986)
J Clin Endocrinol Metab
, vol.62
, pp. 234-237
-
-
Gustavson, L.E.1
Legler, U.F.2
Benet, L.Z.3
-
11
-
-
0036164019
-
The effects of an oral contraceptive containing ethinyloestradiol and norgestel on CYP3A activity
-
Belle DJ, Callaghan JT, Gorski JC et al. The effects of an oral contraceptive containing ethinyloestradiol and norgestel on CYP3A activity. Br J Clin Pharmacol 2002; 53: 67-74.
-
(2002)
Br J Clin Pharmacol
, vol.53
, pp. 67-74
-
-
Belle, D.J.1
Callaghan, J.T.2
Gorski, J.C.3
-
13
-
-
0030050821
-
Comparative pharmacology of newer progestogens
-
Kuhl H. Comparative pharmacology of newer progestogens. Drugs 1996; 51: 188-215.
-
(1996)
Drugs
, vol.51
, pp. 188-215
-
-
Kuhl, H.1
-
14
-
-
0019835546
-
Inhibitors of cytochrome P450s and their mechanism of action
-
Testa B, Jenner P. Inhibitors of cytochrome P450s and their mechanism of action. Drug Metab Rev 1981; 12: 1-117.
-
(1981)
Drug Metab Rev
, vol.12
, pp. 1-117
-
-
Testa, B.1
Jenner, P.2
-
15
-
-
0023883363
-
Oxidation of 17a-ethynylestradiol by human liver cytochrome P-450
-
Guengerich FP. Oxidation of 17a-ethynylestradiol by human liver cytochrome P-450. Mol Pharmacol 1988; 33: 500-8.
-
(1988)
Mol Pharmacol
, vol.33
, pp. 500-508
-
-
Guengerich, F.P.1
-
16
-
-
0025184340
-
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene
-
Guengerich FP. Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene. Chem Res Toxicol 1990; 3: 363-71.
-
(1990)
Chem Res Toxicol
, vol.3
, pp. 363-371
-
-
Guengerich, F.P.1
-
17
-
-
0020533983
-
Suicidal destruction of cytochrome P-450 during oxidative drug metabolism
-
Ortiz de Montellano PR, Correia MA. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism. Ann Rev Pharmacol Toxicol 1983; 23: 481-503.
-
(1983)
Ann Rev Pharmacol Toxicol
, vol.23
, pp. 481-503
-
-
Ortiz De Montellano, P.R.1
Correia, M.A.2
-
18
-
-
0033514320
-
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
-
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 1999; 99: 552-7.
-
(1999)
Circulation
, vol.99
, pp. 552-557
-
-
Fromm, M.F.1
Kim, R.B.2
Stein, C.M.3
Wilkinson, G.R.4
Roden, D.M.5
-
19
-
-
0030589989
-
Steroid transport, accumulation, and antagonism of p-glycoprotein in multidrug-resistant cells
-
Barnes KM, Dickstein B, Cutler GB, Fojo T, Bates SE. Steroid transport, accumulation, and antagonism of p-glycoprotein in multidrug-resistant cells. Biochemistry 1996; 35: 4820-7.
-
(1996)
Biochemistry
, vol.35
, pp. 4820-4827
-
-
Barnes, K.M.1
Dickstein, B.2
Cutler, G.B.3
Fojo, T.4
Bates, S.E.5
-
20
-
-
30144437206
-
Quantitation of sex differences and drug interactions, pharmacologic studies of saquinavir (SQV) in ACTG 2002
-
(Abstract) 779-W
-
Brundage RC, Acosta E, Haubrich R, Katzenstein D, Gulick R, Fletcher CV. Quantitation of sex differences and drug interactions, pharmacologic studies of saquinavir (SQV) in ACTG 2002, 359. 9th Conference on Retroviruses and Opportunistic Infections: (Abstract) 779-W.
-
9th Conference on Retroviruses and Opportunistic Infections
, pp. 359
-
-
Brundage, R.C.1
Acosta, E.2
Haubrich, R.3
Katzenstein, D.4
Gulick, R.5
Fletcher, C.V.6
-
21
-
-
1542267944
-
-
CDER New and Generic Drug Approvals. Capsules, Hoffman-La Roche, Inc
-
CDER New and Generic Drug Approvals. 1998-2003: Product Label Invirase® (Saquinavir Mesylate). Capsules, Hoffman-La Roche, Inc. Available at: URL. http://www.fda.gov/cder/approval/index.htm.AccessedJuly 2003, 08.
-
19982003: Product Label Invirase® (Saquinavir Mesylate)
-
-
-
22
-
-
0036150281
-
CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro
-
Eagling VA, Wiltshire H, Whitcombe IW, Back DJ. CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica 2002; 32: 1-17.
-
(2002)
Xenobiotica
, vol.32
, pp. 1-17
-
-
Eagling, V.A.1
Wiltshire, H.2
Whitcombe, I.W.3
Back, D.J.4
-
23
-
-
0032518290
-
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
-
Kim RB, Fromm MF, Wandel C et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 1998; 101: 289-94.
-
(1998)
J Clin Invest
, vol.101
, pp. 289-294
-
-
Kim, R.B.1
Fromm, M.F.2
Wandel, C.3
-
24
-
-
0035461510
-
Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatine capsules) administration
-
Buss N, Snell P, Bock J, Hsu A, Jorga K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatine capsules) administration. Br J Clin Pharmacol 2001; 52: 255-64.
-
(2001)
Br J Clin Pharmacol
, vol.52
, pp. 255-264
-
-
Buss, N.1
Snell, P.2
Bock, J.3
Hsu, A.4
Jorga, K.5
-
25
-
-
0037419655
-
Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry
-
Burhenne J, Riedel K-D, Martin-Facklam M, Mikus G, Haefeli WE. Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry. J Chromatogr B 2003; 784: 233-42.
-
(2003)
J Chromatogr B
, vol.784
, pp. 233-242
-
-
Burhenne, J.1
Riedel, K.-D.2
Martin-Facklam, M.3
Mikus, G.4
Haefeli, W.E.5
-
26
-
-
0031024382
-
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Potential contribution to high first-pass metabolism
-
Fitzsimmons ME, Collins JM. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4. Potential contribution to high first-pass metabolism. Drug Metab Dispos 1997; 25: 256-66.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 256-266
-
-
Fitzsimmons, M.E.1
Collins, J.M.2
-
27
-
-
0033636621
-
Rapid detection of the C3435T polymorphism of multidrug resistance gene 1 using fluorogenic hybridization probes
-
Nauck M, Stein U, von Karger S, März W, Wieland H. Rapid detection of the C3435T polymorphism of multidrug resistance gene 1 using fluorogenic hybridization probes. Clin Chem 2000; 46: 1995-7.
-
(2000)
Clin Chem
, vol.46
, pp. 1995-1997
-
-
Nauck, M.1
Stein, U.2
Von Karger, S.3
März, W.4
Wieland, H.5
-
28
-
-
0035104031
-
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
-
Cascorbi I, Gerloff T, Johne A et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001; 69: 169-74.
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 169-174
-
-
Cascorbi, I.1
Gerloff, T.2
Johne, A.3
-
29
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O et al. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97: 3473-3347.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3473-13347
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
-
30
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
Kim RB, Leake BF, Choo EF et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001; 70: 189-99.
-
(2001)
Clin Pharmacol Ther
, vol.70
, pp. 189-199
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
-
31
-
-
0035987163
-
Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL
-
Martin-Facklam M, Burhenne J, Ding R et al. Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL. Br J Clin Pharmacol 2002; 53: 576-81.
-
(2002)
Br J Clin Pharmacol
, vol.53
, pp. 576-581
-
-
Martin-Facklam, M.1
Burhenne, J.2
Ding, R.3
-
32
-
-
0029897059
-
Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection
-
Noble S, Faulds D. Saquinavir. A review of its pharmacology and clinical potential in the management of HIV infection. Drugs 1996; 52: 93-112.
-
(1996)
Drugs
, vol.52
, pp. 93-112
-
-
Noble, S.1
Faulds, D.2
-
33
-
-
0029644513
-
Safety and activity of saquinavir in HIV infection
-
Kitchen VS, Skinner C, Ariyoshi K et al. Safety and activity of saquinavir in HIV infection. Lancet 1995; 345: 952-5.
-
(1995)
Lancet
, vol.345
, pp. 952-955
-
-
Kitchen, V.S.1
Skinner, C.2
Ariyoshi, K.3
-
34
-
-
7344253584
-
Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients
-
Mitsuyasu RT, Skolnik PR, Cohen SR et al. Activity of the soft gelatin formulation of saquinavir in combination therapy in antiretroviral-naive patients. AIDS 1998; 12: F103-F109.
-
(1998)
AIDS
, vol.12
-
-
Mitsuyasu, R.T.1
Skolnik, P.R.2
Cohen, S.R.3
-
35
-
-
0032987962
-
Drug interactions of HIV protease inhibitors
-
Malaty LI, Kuper JJ. Drug interactions of HIV protease inhibitors. Drug Saf 1999; 20: 147-69.
-
(1999)
Drug Saf
, vol.20
, pp. 147-169
-
-
Malaty, L.I.1
Kuper, J.J.2
-
36
-
-
0031908050
-
Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man
-
Kupferschmidt HH, Fattinger KE, Ha HR, Follath F, Krähenbühl S. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol 1998; 45: 355-9.
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 355-359
-
-
Kupferschmidt, H.H.1
Fattinger, K.E.2
Ha, H.R.3
Follath, F.4
Krähenbü hl, S.5
-
37
-
-
0036784516
-
Interaction of cytochrome P450 2002, 3A inhibitors with P-glycoprotein
-
Yasuda K, Lan L-B, Sanglard D, Furuya K, Schuetz JD, Schuetz EG. Interaction of cytochrome P450 2002, 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther 303: 323-32.
-
J Pharmacol Exp Ther
, vol.303
, pp. 323-332
-
-
Yasuda, K.1
Lan, L.-B.2
Sanglard, D.3
Furuya, K.4
Schuetz, J.D.5
Schuetz, E.G.6
-
38
-
-
0025325040
-
Reversal of the multidrug resistance phenotype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs
-
Woodcock DM, Jefferson S, Linsenmeyer ME et al. Reversal of the multidrug resistance phenotype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs. Cancer Res 1990; 50: 4199-203.
-
(1990)
Cancer Res
, vol.50
, pp. 4199-4203
-
-
Woodcock, D.M.1
Jefferson, S.2
Linsenmeyer, M.E.3
-
40
-
-
0031959294
-
The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin
-
Backman JT, Kivisto KT, Olkkola KT, Neuvonen PJ. The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin. Eur J Clin Pharmacol 1998; 54: 53-8.
-
(1998)
Eur J Clin Pharmacol
, vol.54
, pp. 53-58
-
-
Backman, J.T.1
Kivisto, K.T.2
Olkkola, K.T.3
Neuvonen, P.J.4
-
41
-
-
0031765907
-
Role of P-glycoprotein and cytochrome P450 1998, 3A in limiting oral absorption of peptides and peptidomimetics
-
Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 1998, 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 87: 1322-8.
-
(1322)
J Pharm Sci 87
, vol.8
-
-
Wacher, V.J.1
Silverman, J.A.2
Zhang, Y.3
Benet, L.Z.4
-
42
-
-
0031914073
-
Saquinavir. Clinical pharmacology and efficacy
-
Vella S, Floridia M. Saquinavir. Clinical pharmacology and efficacy. Clin Pharmacokinet 1998; 34: 189-201.
-
(1998)
Clin Pharmacokinet
, vol.34
, pp. 189-201
-
-
Vella, S.1
Floridia, M.2
-
43
-
-
0033867047
-
Saquinavir soft-gel capsule. An updated review of its use in the management of HIV infection
-
Figgitt DP, Plosker GL. Saquinavir soft-gel capsule. An updated review of its use in the management of HIV infection. Drugs 2000, 2002; 60: 481-516.
-
(2002)
Drugs 2000
, vol.60
, pp. 481-516
-
-
Figgitt, D.P.1
Plosker, G.L.2
-
45
-
-
0035461510
-
Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration
-
Buss N, Snell P, Bock J, Hsu A, Jorga K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. Br J Clin Pharmacol 2001; 52: 255-64.
-
(2001)
Br J Clin Pharmacol
, vol.52
, pp. 255-264
-
-
Buss, N.1
Snell, P.2
Bock, J.3
Hsu, A.4
Jorga, K.5
-
46
-
-
0023236937
-
The metabolism of 17a-ethinyloestradiol by human liver microsomes: Formation of catechol and chemically reactive metabolites
-
Purba HS, Maggs JL, Orme MLE, Back DJ, Park BK. The metabolism of 17a-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites. Br J Clin Pharmac 1987; 23: 447-53.
-
(1987)
Br J Clin Pharmac
, vol.23
, pp. 447-453
-
-
Purba, H.S.1
Maggs, J.L.2
Orme, M.L.E.3
Back, D.J.4
Park, B.K.5
-
47
-
-
0001622254
-
In vitro interaction of contraceptive steroids with human liver cytochrome P-450 enzymes
-
Böcker R, Kleingeist B, Eichhorn M, Lepper H. In vitro interaction of contraceptive steroids with human liver cytochrome P-450 enzymes. Adv Contracept 1991; 7(Suppl 3): 140-8.
-
(1991)
Adv Contracept
, vol.7
, Issue.3 SUPPL.
, pp. 140-148
-
-
Böcker, R.1
Kleingeist, B.2
Eichhorn, M.3
Lepper, H.4
-
48
-
-
0025967698
-
Effect of the progestogens, gestodene, 3-ketodesogestrel, levonorgestrel, norethisterone and norgestimate on the oxidation of ethinyloestradiol and other substrates by human liver microsomes
-
Back DJ, Houlgrave R, Tjia JF, Ward S, Orme MLE. Effect of the progestogens, gestodene, 3-ketodesogestrel, levonorgestrel, norethisterone and norgestimate on the oxidation of ethinyloestradiol and other substrates by human liver microsomes. J Steroid Biochem Molec Biol 1991; 38: 219-25.
-
(1991)
J Steroid Biochem Molec Biol
, vol.38
, pp. 219-225
-
-
Back, D.J.1
Houlgrave, R.2
Tjia, J.F.3
Ward, S.4
Orme, M.L.E.5
-
49
-
-
0021676839
-
Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics
-
Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB. Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics. Clin Pharmacol Ther 1984; 36: 683-90.
-
(1984)
Clin Pharmacol Ther
, vol.36
, pp. 683-690
-
-
Stoehr, G.P.1
Kroboth, P.D.2
Juhl, R.P.3
Wender, D.B.4
Phillips, J.P.5
Smith, R.B.6
-
50
-
-
0031748173
-
In vitro and in vivo drug interactions involving human CYP3A
-
Thummel KE, Wilkinson GR. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 1998; 38: 389-430.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 389-430
-
-
Thummel, K.E.1
Wilkinson, G.R.2
|