Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and pbpk modeling

Journal of Toxicology and Environmental Health - Part A

Volumn 60, Issue 8, 2000, Pages 531-548

  Thrall, K D ^a   Vucelick, M E ^b   Gies, R A ^a   Zangar, R C ^a   Weitz, K K ^a   Poet, T S ^a   Springer, D L ^a   Grant, D M ^a,d   Benson, J M ^c  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^d PURDUE PHARMA L P   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; DOMESTIC CHEMICAL; LIVER PROTEIN;

ANIMAL TISSUE; ARTICLE; BODY BURDEN; CONCENTRATION RESPONSE; CONTROLLED STUDY; GAS ANALYSIS; HAMSTER; LIVER TOXICITY; MALE; METABOLISM; MOUSE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOACTIVITY; RAT; SPECIES DIFFERENCE;

ADMINISTRATION, INHALATION; ANIMALS; CARBON TETRACHLORIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; ENVIRONMENTAL POLLUTANTS; HUMANS; MALE; MESOCRICETUS; MICE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; RATS; RATS, INBRED F344; RATS, INBRED STRAINS;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0034714559     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/00984100050082085     Document Type: Article

References (30)

1. Agency for Toxic Substances and Disease Registry. 1994. Toxicological Profile for Carbon Tetrachloride. U.S. Department of Health and Human Services, Public Health Service, TP-93/02. Atlanta, GA.
2. Ahmad, F. F., Cowan, D. L., and Sun, A. Y. 1987. Detection of free radical formation in various tissues after acute carbon tetrachloride adm inistration in gerbil. Life Sci. 41:2469-2475.
3. Andersen, M. E., Clewell, H. J. III, Gargas, M. L., Smith, F. A., and Reitz, R. H. 1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87:185-205.
4. Andersen, N. J., Waller, C. L., Adamovic, J. B., Thompson, D. J., Allis, J. W., Andersen, M. E., and Simmons, J. E. 1996. A pharmacokinetic model of anaerobic in vitro carbon tetrachloride metabolism. Chem. Biol. Interact. 101:13-31.
5. Bruckner, J. V., MacKenzie, W. F., Muralidhara, S., Luthra, R., Kyle, G. M., and Acosta, D. 1986. Oral toxicity of carbon tetrachloride: Acute, subacute and subchronic studies in rats. Fundam. Appl. Toxicol. 6:16-34.
6. Connor, H. D., Thurman, R. G., Galizi, M. D., and Mason, R. P. 1986. The formation of a novel free radical metabolite from CCl4 in the perfused rat liver and in vivo. J. Biol. Chem. 261:4542-4548.
7. Corley, R. A., Mendrala, A. M., Smith, F. A., Staats, D. A., Gargas, M. L., Conolly, R. B., Andersen, M. E., and Reitz, R. H. 1990. Development of a physiologically-based pharmacokinetic model for chloroform. Toxicol. Appl. Pharmacol. 103:512-527.
8. Dianzani, M. U. 1987. The role of free radicals in liver damage. Proc. Nutr. Soc. 46:43-52.
9. Evans, M. R., Crank, W. D., Yang, H.-M., and Simmons, J. E. 1994. Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicol. Appl. Pharmacol. 128:36-44.
10. Gargas, M. L., Andersen, M. E., and Clewell, H. J. III. 1986. A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86:341-352.
11. Guyton, A. C. 1947. Respiratory volumes of laboratory animals. Am. J. Physiol. 150:70-77.
12. Noguchi, T., Fong, K.-L., Lai, E. K., Olson, L., and McCay, P. B. 1982a. Selective early loss of polypeptides in liver microsomes of CCl-treated rats. Relationship to cytochrome P-450 content. Biochem. Pharmacol. 31:609-614.
13. Noguchi, T., Fong, K.-L., Lai, E. K., Alexander, S. S., King, M. M., Olson, L., Poyer, J. L., Floyd, R. A., and McCay, P. B. 1982b. Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical. Biochem. Pharmacol. 31:615-624.
14. Paustenbach, D. J., Clewell, H. J. III, Gargas, M. L., and Andersen, M. E. 1988. A physiologically based pharmacokinetic model for inhaled carbon tetrachloride. Toxicol. Appl. Pharmacol.96:191-211.
15. Persson, J.-O., Terelius, Y., and Ingelman-Sundberg, M. 1990. Cytochrome P-450-dependent formation of reactive oxygen radicals: Isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride. Xenobiotica 20:887-900.
16. Recknagel, R. O. 1983. A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci. 33:401-408.
17. Recknagel, R. O., and Glende, E. A., Jr. 1973. Carbon tetrachloride hepatotoxicity: An example of lethal cleavage. CRC Crit. Rev. Toxicol. 2:263-297.
18. Reitz, R. H., Mendrala, A. L., and Guengerich, F. P. 1989. In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically-based pharmacokinetic models. Toxicol. Appl. Pharmacol.97:230-246.
19. Reitz, R. H., Gargas, M. L., Mendrala, A. L., and Schumann, A. M. 1996. In vivo and in vitro studies of perchloroethylene metabolism for physiologically based pharmacokinetic modeling in rats, mice, and humans. Toxicol. Appl. Pharmacol. 136:289-306.
20. Sato, A., and Nakajima, T. 1979. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood, and oil. Br. J. Ind. Med. 36:231-234.
21. Simmons, J. E., Schoeffner, D. J., Bruckner, J. V., and Evans, M. V. 1999. Investigation of the enhanced susceptibility of the aged rat to carbon tetrachloride (CC^) by development of a physiologically-based pharmacokinetic (PBPK) model with age-specific input parameters. Toxicol. Sci. 48(1-S):142.
22. Staples, C. A., Werner, A. F., and Hoogheem, T. J. 1985. Assessment of priority pollutant concentrations in the United States using the Storet database. Environ. Toxicol. Chem. 4:131-142.
23. Stewart, R. D., Gay, H. H., Erley, D. S., Hake, C. L., and Peterson, J. E. 1961. Human exposure to carbon tetrachloride vapor-Relationship of expired air concentration to exposure and toxicity. J. Occup. Med. 3:586-590.
24. Thrall, K. D., and Kenny, D. V. 1996. Evaluation of a carbon tetrachloride physiologically based pharmacokinetic model using real-time breath-analysis monitoring of the rat. Inhal. Toxicol. 8: 251-261.
25. Uemitsu, N. 1986. Inhalation pharmacokinetics of carbon tetrachloride in rats based on arterial blood:inhaled air concentration ratios. Toxicol. Appl. Pharmacol. 83:20-29.
26. Uemitsu, N., Nishimura, C., and Nakayoshi, H. 1986. Evaluation of liver weight changes following repeated administration of carbon tetrachloride in rats and body-liver weight relationship. Toxicology 40:181-190.
27. U.S. Environmental Protection Agency. 1998. Carbon Tetrachloride. U.S. Environmental Protection Agency, Integrated Risk Information System. Washington, DC.
28. Veng-Pedersen, P. 1984. Pulmonary absorption and excretion of compounds in the gas phase. J. Pharm. Sci. 73:1136-1141.
29. Veng-Pedersen, P., Paustenbach, D. J., Suarez, L., and Carlson, G. P. 1987. A linear systems approach to analyzing the pharmacokinetics in the rat following repeated exposures of 8-11.5 hours/day. Arch. Toxicol. 60:355-364.
30. Zangar, R. C., Benson, J. M., Burnett, V. L., and Springer, D. L. 2000. Cytochrome P450 2E1is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem. Biol. Interact. 125:233-243.