Association between Allelic Variation of Serotonin Transporter Function and Neuroticism in Anxious Cluster C Personality Disorders

American Journal of Psychiatry

Volumn 161, Issue 3, 2004, Pages 569-572

  Jacob, Christian P ^a   Strobel, A ^a   Hohenberger, K ^a   Ringel, T ^a   Gutknecht, L ^a   Reif, A ^a   Brocke, B ^a   Lesch, K P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; ALLELE; ANALYSIS OF VARIANCE; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DETERMINATION; DNA EXTRACTION; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROSIS; PERSONALITY DISORDER; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN FUNCTION; QUESTIONNAIRE; RATING SCALE; SCORING SYSTEM; TRANSCRIPTION REGULATION;

ADULT; ALLELES; ANXIETY DISORDERS; CARRIER PROTEINS; FEMALE; HETEROZYGOTE DETECTION; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; PERSONALITY DISORDERS; PERSONALITY INVENTORY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PSYCHOMETRICS; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ENVIRONMENT; TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 1542283785     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.161.3.569     Document Type: Article

References (22)

1. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1530
2. Mortensen OV, Thomassen M, Larsen MB, Whittemore SR, Wiborg O: Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res 1999; 68:141-148
3. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, DelProposto ZS, Hill E, Cassin BJ, Watson SJ, Cook EH: Cocaine, ethanol, and genotype effects on human mid-brain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 1998; 155:207-213
4. Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL: Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 2000; 96:202-216
5. Reist C, Mazzanti C, Vu R, Tran D, Goldman D: Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. Am J Med Genet 2001; 105:363-368
6. Whale R, Quested DJ, Laver D, Harrison PJ, Cowen PJ: Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine. Psychopharmacology (Berl) 2000; 150:120-122
7. Neumeister A, Konstantinidis A, Stastny J, Schwarz MJ, Vitouch O, Willeit M, Praschak-Rieder N, Zach J, de Zwaan M, Bondy B, Ackenheil M, Kasper S: Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch Gen Psychiatry 2002; 59:613-620
8. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, Linnoila M, Weinberger DR: A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 1999; 47:643-649
9. Collier DA, Stoeber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Pak S, Lesch KP: A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1:453-460
10. Lesch KP: Neuroticism and serotonin: a developmental genetic perspective, in Behavioral Genetics in the Postgenomic Era. Edited by Plomin R, DeFries J, Craig I, McGuffin P. Arlington, Va, American Psychiatric Press, 2003, pp 389-423
11. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297:400-403
12. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R: Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301:386-389
13. First MB, Spitzer RL, Gibbon M, Williams JBW, Benjamin L: The Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II). New York, New York State Psychiatric Institute, Biometrics Research Unit, 1995
14. Plomin R, Owen MJ, McGuffin P: The genetic basis of complex human behaviors. Science 1994; 264:1733-1739
15. Eley TC, Plomin R: Genetic analyses of emotionality. Curr Opin Neurobiol 1997; 7:279-284
16. Costa PT, McCrae RR: Revised NEO Personality Inventory (NEOPI-R) and NEO Five Factor Inventory (NEO-FFI): professional manual. Odessa, Fla, Psychological Assessment Resources, 1992
17. Cloninger CR, Przybeck TR, Svrakic DM: The Tridimensional Personality Questionnaire: U.S. normative data. Psychol Rep 1991; 69:1047-1057
18. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Champoux M, Suomi SJ, Linnoila MV, Higley JD: Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002; 7:118-122
19. Davidson RJ: Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 2002; 51:68-80
20. Champoux M, Bennett A, Shannon C, Higley JD, Lesch KP, Suomi SJ: Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates. Mol Psychiatry 2002; 7:1058-1063
21. Iketani T, Kiriike N, Stein MB, Nagao K, Nagata T, Minamikawa N, Shidao A, Fukuhara H: Personality disorder comorbidity in panic disorder patients with or without current major depression. Depress Anxiety 2002; 15:176-182
22. Kendler KS: Major depression and generalised anxiety disorder: same genes, (partly) different environments-revisited. Br J Psychiatry Suppl 1996; 30:68-75