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46
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The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
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Cariappa A., Tang M., Parng C., Nebelitskiy E., Carroll M., Georgopoulos K., Pillai S. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 14:2001;603-615.
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Cariappa, A.1
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Pillai, S.7
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47
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0037240911
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Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development
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Development of anti-Thy-1 glycoprotein B-1 cells is blocked at a transitional stage during bone marrow development. This study reinforces the idea that some B-1 cells are formed early in ontogeny.
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Hayakawa K., Asano M., Shinton S.A., Gui M., Wen L.J., Dashoff J., Hardy R.R. Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med. 197:2003;87-99 Development of anti-Thy-1 glycoprotein B-1 cells is blocked at a transitional stage during bone marrow development. This study reinforces the idea that some B-1 cells are formed early in ontogeny.
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Hayakawa, K.1
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Hardy, R.R.7
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48
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Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1
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Borrero M., Clarke S.H. Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1. J Immunol. 168:2002;13-21.
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Borrero, M.1
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0033367799
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B1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice
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Bao S., Husband A.J., Beagley K.W. B1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice. Cell Immunol. 198:1999;139-142.
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Bao, S.1
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50
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13344277358
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IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
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Kopf M., Brombacher F., Hodgkin P.D., Ramsay A.J., Milbourne E.A., Dai W.J., Ovington K.S., Behm C.A., Kohler G., Young I.G.et al. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 4:1996;15-24.
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Kopf, M.1
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51
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0037061453
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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
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This study uncovered an important mechanism of B-cell activation: that ligation of both BCR and Toll-like receptor is essential for activation of autoreactive B cells. This raises the possibility that ligation of the TLR by either apoptotic cells or lipopolysaccharide could affect BCR signaling strength, thereby influence B-cell development.
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Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:2002;603-607 This study uncovered an important mechanism of B-cell activation: that ligation of both BCR and Toll-like receptor is essential for activation of autoreactive B cells. This raises the possibility that ligation of the TLR by either apoptotic cells or lipopolysaccharide could affect BCR signaling strength, thereby influence B-cell development.
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Nature
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Leadbetter, E.A.1
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Marshak-Rothstein, A.6
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52
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0242695061
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The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells
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Membrane-bound and soluble forms of hen-egg lysozyme (HEL) induce deletion and anergy in anti-HEL Tg mice, respectively. However, HEL expressed intracellularly induced B-1 cell development and antibody production. This suggests that antigen localization plays an important role in selection of B cells.
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Ferry H., Jones M., Vaux D.J., Roberts I.S., Cornall R.J. The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells. J Exp Med. 198:2003;1415-1425 Membrane-bound and soluble forms of hen-egg lysozyme (HEL) induce deletion and anergy in anti-HEL Tg mice, respectively. However, HEL expressed intracellularly induced B-1 cell development and antibody production. This suggests that antigen localization plays an important role in selection of B cells.
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Ferry, H.1
Jones, M.2
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53
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9144244817
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Cutting Edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function
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This study reports that BAFF is not required for maturation of mature FO and MZ B cells, as previously believed.
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Gorelik L., Cutler A.H., Thill G., Miklasz S.D., Shea D.E., Ambrose C., Bixler S.A., Su L., Scott M.L., Kalled S.L. Cutting Edge: BAFF regulates CD21/ 35 and CD23 expression independent of its B cell survival function. J Immunol. 172:2004;762-766 This study reports that BAFF is not required for maturation of mature FO and MZ B cells, as previously believed.
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Gorelik, L.1
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Ambrose, C.6
Bixler, S.A.7
Su, L.8
Scott, M.L.9
Kalled, S.L.10
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