Effects of the CRF1 antagonist SSR125543A on aggressive behaviors in hamsters

Pharmacology Biochemistry and Behavior

Volumn 77, Issue 3, 2004, Pages 465-469

  Farrokhi, Catherine ^a   Blanchard, D Caroline ^b   Griebel, Guy ^c   Yang, Mu ^a   Gonzales, Coty ^a   Markham, Chris ^a   Blanchard, Robert J ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c SANOFI   (France)

Author keywords

Agression; Anxiolytic like effect; Corticotropin releasing factor

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; SSR 125543 A; UNCLASSIFIED DRUG;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; BITE; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; LATENT PERIOD; MALE; NONHUMAN; OLFACTORY SYSTEM; PRIORITY JOURNAL; SOCIAL BEHAVIOR; SYRIAN HAMSTER;

AGGRESSION; ANIMALS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESOCRICETUS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; THIAZOLES;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 1542270300     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2003.12.023     Document Type: Article

References (36)

1. Arborelius L., Owens M.J., Plotsky P.M., Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol. 60:1999;1-12.
2. Arborelius L., Skeleton K.H., Thrivikraman K.V., Plotsky P.M., Schulz D.W., Owen M.J. Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat. J. Pharmacol. Exp. Ther. 294:2000;588-597.
3. Blanchard R.J., Blanchard D.C. Antipredator defensive behaviors in a visible burrow system. J. Comp. Psychol. 103:1989;70-82.
4. Blanchard R.J., Blanchard D.C. Aggressive behavior in the rat. Behav. Biol. 21:1997;197-224.
5. Blanchard R.J., Kleinschmidt C.F., Fukunaga-Stinson C., Blanchard D.C. Defensive attack behavior in male and female rats. Anim. Learn. Behav. 8:1980;177-183.
6. Blanchard D.C., Takushi R., Blanchard R.J., Flannelly K.J., Kemble E.D. Fluprazine hydrochloride does not decrease defensive behaviors of wild and septal syndrome rats. Physiol. Behav. 35:1985;349-353.
7. Blanchard R.J., Blanchard D.C., Flannelly K.J., Hori K. Ethanol effects on freezing and conspecific attack in rats previously exposed to a cat. Behav. Processes. 16:1988;193-201.
8. Cador M., Ahmed S.H., Koob G.F., Le Moal M., Stinus L. Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role. Brain Res. 597:1992;304-309.
9. Chalmers D.T., Lovenberg T.W., Grigoriadis D.E., Behan D.P., De Souza E.B. Corticotropin-releasing factor receptors: from molecular biology to drug design. Trends Pharmacol. Sci. 17:1996;166-172.
10. Contarino A., Dellu F., Koob G.F., Smith G.W., Lee K.F., Vale W.et al. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res. 835:1999;1-9.
11. Elkabir D.R., Wyatt M.E., Vellucci S.V., Herbert J. The effects of separate or combined infusions of corticotropin-releasing factor and vasopressin either intraventricularly or into the amygdala on aggressive and investigative behaviour in the rat. Regul. Pept. 28:1990;199-214.
12. Gray T.S., Bingaman E.W. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit. Rev. Neurobiol. 10:1996;155-168.
13. Griebel G. Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders? Pharmacol. Ther. 82:1999;1-61.
14. Griebel G., Perrault G., Sanger D.J. Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone. Psychopharmacology (Berl). 138:1998;55-66.
15. Griebel G., Simiand J., Steinberg R., Jung M., Gully D., Roger P.et al. 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4- methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotropin-releasing factor(1) receptor antagonist: II. Characterization in rodent models of stress-related disorders. J. Pharmacol. Exp. Ther. 301:2002;333-345.
16. Gully D., Geslin M., Serva L., Fontaine E., Roger P., Lair C.et al. 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4- methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotropin-releasing factor(1) receptor antagonist: I. Biochemical and pharmacological characterization. J. Pharmacol. Exp. Ther. 301:2002;322-332.
17. Habib K.E., Weld K.P., Rice K.C., Pushkas J., Champoux M., Listwak S.et al. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6079-6084.
18. Haller J., Millar S., Kruk M.R. Mineralocorticoid receptor blockade inhibits aggressive behaviour in male rats. Stress. 2:1998;201-207.
19. Haller J., Halasz J., Mikics E., Kruk M.R., Makara G.B. Ultradian corticosterone rhythm and the propensity to behave aggressively in male rats. J. Neuroendocrinol. 12:2000;937-940.
20. Haller J., Millar S., van de Schraaf J., de Kloet R.E., Kruk M.R. The active phase-related increase in corticosterone and aggression are linked. J. Neuroendocrinol. 12:2002;431-436.
21. Lundkvist J., Chai Z., Teheranian R., Hasanvan H., Bartfai T., Jenck F., Widmer U., Moreau J.L. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur. J. Pharmacol. 309:1996;195-200.
22. Mansbach R.S., Brooks E.N., Chen Y.L. Antidepressant-like effects of CP-154,526, a selective CRF1 receptor antagonist. Eur. J. Pharmacol. 323:1997;21-26.
23. Mele A., Cabib S., Oliverio A., Melchiorri P., Puglisi-Allegra S. Effects of corticotropin releasing factor and sauvagine on social behavior of isolated mice. Peptides. 8:1987;935-938.
24. Olivier B., Mos J., Mizcek K.A. Ethopharmacological studies of anxiolytics and aggression. Eur. Neuropsychopharmacol. 1:1991;97-100.
25. Olschowka J.A., O'Donohue T.L., Mueller G.P., Jacobowitz D.M. The distribution of corticotropin-releasing factor-like immunoreactive neurons in the rat brain. Peptides. 3:1982;995-1015.
26. Owens M.J., Nemeroff C.B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev. 43:1991;425-473.
27. Primus R.J., Yevich E., Baltazar C., Gallager D.W. Autoradiographic localization of CRF1 and CRF2 binding sites in the adult rat brain. Neuropsychopharmacology. 17:1997;308-316.
28. Rivier C. Inhibitory effect of neurogenic and immune stressors on testosterone secretion in rats. Neuroimmunomodulation. 10:2002;17-29.
29. Rivier C.L., Grigoriadis D.E., Rivier J.E. Role of corticotropin- releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. Endocrinology. 144:2003;2396-2403.
30. Schulz D.W., Mansbach R.S., Sprouse J., Braselton J.P., Collins J., Corman M., Dunaiskis A., Faraci S., Schmidt A.W., Seeger T., Seymour P., Tingley F.D. 3rd, Winston E.N., Chen Y.L., Heym J. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. U.S.A. 93:1996;10477-10482.
31. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H.et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 20:1998;1102-1993.
32. Swanson L.W., Sawchenko P.E., Rivier J., Vale W. Organization of the ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat: an immunohistochemical study. Neuroendocrinology. 36:1983;165-186.
33. Takahashi L.K. Role of CRF(1) and CRF(2) receptors in fear and anxiety. Neurosci. Biobehav. Rev. 25(7-8):2001;627-636.
34. Tazi A., Dantzer R., Le Moal M., Rivier J., Vale W., Koob G.F. Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats. Regul. Pept. 18:1987;37-42.
35. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M., Stalla G.K.et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor. Nat. Genet. 19(2):1998;162-166. (June).
36. Vale W.W., Spiess J., Rivier C., Rivier J. Characterization of a 41 residues ovine hypothalamic peptide that stimulates the secretion of corticotropin and β-endorphin. Science (Wash. D.C.). 213:1981;1394-1397.