NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection

Journal of Virology

Volumn 79, Issue 7, 2005, Pages 4470-4478

  Gill, Navkiran ^a   Rosenthal, Kenneth L ^a   Ashkar, Ali A ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERLEUKIN 15; OLIGODEOXYNUCLEOTIDE; RECOMBINANT INTERLEUKIN 15; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; INFECTION SENSITIVITY; INNATE IMMUNITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SURVIVAL; T LYMPHOCYTE; VAGINA EPITHELIUM; VAGINA MUCOSA; VAGINITIS; VIRUS INFECTION; VIRUS TITRATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-15; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; PLAQUE ASSAY; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA; VAGINA; VAGINAL DISEASES;

EID: 15244351040     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.7.4470-4478.2005     Document Type: Article

References (38)

1. Adams, O., K. Besken, C. Oberdorfer, C. R. Mackenzie, D. Russing, and W. Daubener. 2004. Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase. Microbes Infect. 6:806-812.
2. Ahmad, A., E. Sharif-Askari, L. Fawaz, and J. Menezes. 2000. Innate immune response of the human host to exposure with herpes simplex virus type 1: in vitro control of the virus infection by enhanced natural killer activity via interleukin-15 induction. J. Virol. 74:7196-7203.
3. Ashkar, A. A., S. Bauer, W. J. Mitchell, J. Vieira, and K. L. Rosenthal. 2003. Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2. J. Virol. 77:8948-8956.
4. Ashkar, A. A., and K. L. Rosenthal. 2003. Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J. Virol. 77:10168-10171.
5. Biron, C. A. 1999. Initial and innate responses to viral infections-pattern setting in immunity or disease. Curr. Opin. Microbiol. 2:374-381.
6. Biron, C. A., and L. Brossay. 2001. NK cells and NKT cells in innate defense against viral infections. Curr. Opin. Immunol. 13:458-464.
7. Biron, C. A., K. B. Nguyen, G. C. Pien, L. P. Cousens, and T. P. Salazar-Mather. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189-220.
8. Carson, W. E., and M. A. Caligiuri. 1996. Interleukin 15: a potential player during the innate immune response to infection. Exp. Parasitol. 84:291-294.
9. Carson, W. E., T. A. Fehniger, S. Haldar, K. Eckhert, M. J. Lindemann, C. F. Lai, C. M. Croce, H. Baumann, and M. A. Caligiuri. 1997. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J. Clin. Investig. 99:937-943.
10. Carson, W. E., J. G. Gin, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Andersen, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395-1403.
11. Duerst, R. J., and L. A. Morrison. 2003. Innate immunity to herpes simplex virus type 2. Viral Immunol. 16:475-490.
12. Ellis, A. E. 2001. Innate host defense mechanisms of fish against viruses and bacteria. Dev. Comp. Immunol. 25:827-839.
13. Fawaz, L. M., E. Sharif-Askari, and J. Menezes. 1999. Up-regulation of NK cytotoxic activity via IL-15 induction by different viruses: a comparative study. J. Immunol. 163:4473-4480.
14. Fehniger, T. A., and M. A. Caligiuri. 2001. Interleukin 15: biology and relevance to human disease. Blood 97:14-32.
15. Fehniger, T. A., K. Suzuki, A. Ponnappan, J. B. VanDeusen, M. A. Cooper, S. M. Florea, A. G. Freud, M. L. Robinson, J. Durbin, and M. A. Caligiuri. 2001. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J. Exp. Med. 193:219-231.
16. Fehniger, T. A., K. Suzuki, J. B. VanDeusen, M. A. Cooper, A. G. Freud, and M. A. Caligiuri. 2001. Fatal leukemia in interleukin-15 transgenic mice. Blood Cells Mol. Dis. 27:223-230.
17. Flamand, L., I. Stefanescu, and J. Menezes. 1996. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Investig. 97:1373-1381.
18. Freihorst, J., and P. L. Ogra. 2001. Mucosal immunity and viral infections. Ann. Med. 33:172-177.
19. Gosselin, J., A. Tomolu, R. C. Gallo, and L. Flamand. 1999. Interleukin-15 as an activator of natural killer cell-mediated antiviral response. Blood 94: 4210-4219.
20. Grubor-Bauk, B., A. Simmons, G. Mayrhofer, and P. G. Speck. 2003. Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR. J. Immunol. 170:1430-1434.
21. Harandi, A. M., K. Eriksson, and J. Holmgren. 2003. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol. 77:953-962.
22. Herbst, M. M., and R. B. Pyles. 2003. Immunostimulatory CpG treatment for genital HSV-2 infections. J. Antimicrob. Chemother. 52:887-889.
23. Karlin, S., W. Doerfler, and L. R. Cardon. 1994. Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? J. Virol. 68:2889-2897.
24. Kennedy, M. K., M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. R. Willis, K. Brasel, P. J. Morrissey, K. Stocking, J. C. Schuh, S. Joyce, and J. J. Peschon. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191:771-780.
25. Liu, G., Q. Zhai, D. Schaffner, C. Bradburne, A. Wu, A. Hayford, S. Popov, E. Grene, C. Bailey, and K. Alibek. 2004. IL-15 induces IFN-beta and iNOS gene expression, and antiviral activity of murine macrophage RAW 264.7 cells. Immunol. Lett. 91:171-178.
26. Lund, J., A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki. 2003. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198:513-520.
27. Mastroianni, C. M., G. d'Ettorre, G. Forcina, M. Lichtner, F. Mengoni, C. D'Agostino, A. Corpolongo, A. P. Massetti, and V. Vullo. 2000. Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection. Blood 96:1979-1984.
28. McDermott, M. R., J. R. Smiley, P. Leslie, J. Brais, H. E. Rudzroga, and J. Bienenstock. 1984. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. J. Virol. 51:747-753.
29. Ohteki, T. 2002. Critical role for IL-15 in innate immunity. Curr. Mol. Med. 2:371-380.
30. Ohteki, T., K. Suzue, C. Maki, T. Ota, and S. Koyasu. 2001. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2:1138-1143.
31. Puzanov, I. J., M. Bennett, and V. Kumar. 1996. IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells. J. Immunol. 157:4282-4285.
32. Pyles, R. B., D. Higgins, C. Chalk, A. Zalar, J. Eiden, C. Brown, G. Van Nest, and L. R. Stanberry. 2002. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J. Virol. 76:11387-11396.
33. Sajic, D., A. A. Ashkar, A. J. Patrick, M. J. McCluskie, H. L. Davis, K. L. Levine, R. Holl, and K. L. Rosenthal. 2003. Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge. J. Med. Virol. 71:561-568.
34. Sharif-Askari, E., L. M. Fawaz, P. Tran, A. Ahmad, and J. Menezes. 2001. Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed/immortalized lymphocytes in culture. J. Natl. Cancer Inst. 93:1724-1732.
35. Singh, I. P., and S. Baron. 2000. Innate defences against viraemia. Rev. Med. Virol. 10:395-403.
36. Tsunobuchi, H., H. Nishimura, F. Goshima, T. Daikoku, H. Suzuki, I. Nakashima, Y. Nishiyama, and Y. Yoshikai. 2000. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology 275:57-66.
37. Yanagita, M., Y. Shimabukuro, T. Nozaki, N. Yoshimura, J. Watanabe, H. Koide, M. Terakura, T. Saho, M. Takedachi, M. H. Jang, H. Kiyono, and S. Murakami. 2002. IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells. Biochem. Biophys. Res. Commun. 297:329-334.
38. Zheng, M., D. M. Klinman, M. Gierynska, and B. T. Rouse. 2002. DNA containing CpG motifs induces angiogenesis. Proc. Natl. Acad. Sci. USA 99:8944-8949.