Il-15 up-regulates iNOS expression and NO production by gingival epithelial cells

Biochemical and Biophysical Research Communications

Volumn 297, Issue 2, 2002, Pages 329-334

  Yanagita, Manabu ^a   Shimabukuro, Yoshio ^a   Nozaki, Takenori ^a   Yoshimura, Naoko ^a   Watanabe, Junko ^a   Koide, Hiroko ^a   Terakura, Mami ^a   Saho, Teruyuki ^a   Takedachi, Masahide ^a   Jang, Myoung Ho ^b   Kiyono, Hiroshi ^b   Murakami, Shinya ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Gingival epithelial cells; INOS; Interleukin 15; NO; Periodontal diseases

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GINGIVA; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL SEPARATION; CELLS, CULTURED; CYTOCHALASIN D; ENZYME INDUCTION; ENZYME INHIBITORS; EPITHELIAL CELLS; FLOW CYTOMETRY; GINGIVA; HUMANS; INTERLEUKIN-15; KERATINOCYTES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NUCLEIC ACID SYNTHESIS INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0036403201     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02201-5     Document Type: Article

References (38)

1. M.F. Kagnoff, L. Eckmann, Epithelial cells as sensors for microbial infection, J. Clin. Invest. 100 (1997) 6-10.
2. D.W. McGee, in: Mucosal Immunology, Academic Press, San Diego, CA, 1999, pp. 559-573.
3. A. Ma, D.L. Boone, J.P. Lodolce, The pleiotropic functions of interleukin 15: not so interleukin 2-like after all, J. Exp. Med. 191 (2000) 753-756.
4. Y. Tagaya, R.N. Bamford, A.P. DeFilippis, T.A. Waldmann, IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels, Immunity 4 (1996) 329-336.
5. T.A. Waldmann, Y. Tagaya, The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens, Annu. Rev. Immunol. 49 (1999) 1719-1749.
6. H.C. Reinecker, R.P. MacDermott, S. Mirau, A. Dignass, D.K. Podolsky, Intestinal epithelial cells both express and respond to interleukin 15, Gastroenterology 111 (1996) 1706-1713.
7. T. Hiroi, M. Yanagita, N. Ohta, G. Sakaue, H. Kiyono, IL-15 and IL-15 receptor selectively regulate differentiation of common mucosal immune system-independent B-1 cells for IgA responses, J. Immunol. 165 (2000) 4329-4337.
8. J.G. Giri, S. Kumaki, M. Ahdieh, D.J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L.S. Park, D.M. Anderson, Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor, EMBO J. 14 (1995) 3654-3663.
9. S. Moncada, A. Higgs, The L-arginine-nitric oxide pathway, N. Engl. J. Med. 329 (1993) 2002-2012.
10. C.R. Lyons, The role of nitric oxide in inflammation, Adv. Immunol. 60 (1995) 323-371.
11. K. Asano, C.B. Chee, B. Gaston, C.M. Lilly, C. Gerard, J.M. Drazen, J.S. Stamler, Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells, Proc. Natl. Acad. Sci. USA 91 (1994) 10089-10093.
12. L. Eckmann, F. Laurent, T.D. Langford, M.L. Hetsko, J.R. Smith, M.F. Kagnoff, F.D. Gillin, Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia, J. Immunol. 164 (2000) 1478-1487.
13. M. Fried, C. Prives, in: M. Botchan, T. Grodzicker, P. Sharp (Eds.), Cancer Cells 4: DNA Tumor Viruses, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1986, pp. 1-16.
14. G. Hoffmann, J. Grote, F. Friedrich, N. Mutz, W. Schobersberger, The pulmonary epithelial cell line L 2 as a new model for an inducible nitric oxide synthase expressing distal airway epithelial cell, Biochem. Biophys. Res. Commun. 217 (1995) 575-583.
15. H.K. Kendall, H.R. Haase, Y. Xiao, M.P. Barthold, Nitic oxide synthase type-II is synthesized by human gingival tissue and cultured human gingival fibroblasts, J. Periodont. Res. 35 (2000) 194-200.
16. C. Nathan, Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100 (1997) 2417-2423.
17. A.L. Salzman, T. Eaves Pyles, S.C. Linn, A.G. Denenberg, C. Szabo, Bacterial induction of inducible nitric oxide synthase in cultured human intestinal epithelial cells, Gastroenterology 114 (1998) 93-102.
18. T. Eaves Pyles, K. Murthy, L. Liaudet, L. Virag, G. Ross, F.G. Soriano, C. Szabo, A.L. Salzman, Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: IκB α degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction, J. Immunol. 166 (2001) 1248-1260.
19. I.P. Oswald, I. Eltoum, T.A. Wynn, B. Schwartz, P. Caspar, D. Paulin, A. Sher, S.L. James, Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide, Proc. Natl. Acad. Sci. USA 91 (1994) 999-1003.
20. N. Kumaki, D.M. Anderson, D. Cosman, S. Kumaki, Expression of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells, Curr. Eye Res. 15 (1996) 876-882.
21. S. Murakami, N. Yoshimura, H. Koide, J. Watanabe, M. Takedachi, M. Terakura, M. Yanagita, T. Hashikawa, T. Saho, Y. Shimabukuro, H. Okada, Activation of adenosine receptor enhanced iNOS mRNA expression by gingival epithelial cells, J. Dent. Res. 81 (2002) 236-240.
22. S. Moncada, R.M. Palmer, E.A. Higgs, Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43 (1991) 109-142.
23. M. Nakane, V. Klinghofer, J.E. Kuk, J.L. Donnelly, G.P. Budzik, J.S. Pollock, F. Basha, G.W. Carter, Novel potent and selective inhibitors of inducible nitric oxide synthase, Mol. Pharmacol. 47 (1995) 831-834.
24. D. Bruch Gerharz, K. Fehsel, C. Suschek, G. Michel, T. Ruzicka, V. Kolb Bachofen, A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes, J. Exp. Med. 184 (1996) 2007-2012.
25. M. Umemura, H. Nishimura, K. Hirose, T. Matsuguchi, Y. Yoshikai, Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Gufferin infection via augmentation of NK and T cytotoxic 1 responses, J. Immunol. 167 (2001) 946-956.
26. A.S. MacDonald, A.D. Straw, B. Bauman, E.J. Pearce, CD8-dendritic cell activation status plays an integral role in influencing Th2 response development, J. Immunol. 167 (2001) 1982-1988.
27. K. Yamada, M. Shimaoka, K. Nagayama, T. Hiroi, H. Kiyono, T. Honda, Bacterial invasion induces interleukin-7 receptor expression in colonic epithelial cell line, T84, Eur. J. Immunol. 27 (1997) 3456-3460.
28. M. Weiler, B. Rogashev, T. Einbinder, M.J. Hausmann, J. Kaneti, C. Chaimovitz, A. Douvdevani, Interleukin-15, a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells, J. Am. Soc. Nephrol. 9 (1998) 1194-1201.
29. M. Weiler, L. Kachko, C. Chaimovitz, C. Van Kooten, A. Douvdevani, CD40 ligation enhances IL-15 production by tubular epithelial cells, J. Am. Soc. Nephrol. 12 (2001) 80-87.
30. H. Okada, Y. Shimabukuro, Y. Kassai, H. Ito, T. Matsuo, S. Ebisu, Y. Harada, The function of gingival lymphocytes on the establishment of human periodontitis, Adv. Dent. Res. 2 (1988) 364-367.
31. I. Arany, M.M. Brysk, H. Brysk, S.K. Tyring, Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes, Biochem. Biophys. Res. Commun. 220 (1996) 618-622.
32. J.U. Igietseme, I.M. Uriri, R. Hawkins, R.G. Rank, Integrinmediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia, J. Leukoc. Biol. 59 (1996) 656-662.
33. S. Kwon, S.C. George, Synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells, Nitric Oxide 3 (1999) 348-357.
34. S. Bulfone Paus, E. Bulanova, T. Pohl, V. Budagian, H. Durkop, R. Ruckert, U. Kunzendorf, R. Paus, H. Krause, Death deflected: IL-15 inhibits TNF-α-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain, FASEB J. 13 (1999) 1575-1585.
35. G.J. Della Rocca, S. Maudsley, Y. Daaka, R.J. Lefkowitz, L.M. Luttrell, Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases, J. Biol. Chem. 274 (1999) 13978-13984.
36. N. Niisato, Y. Marunaka, Blocking action of cytochalasin D on protein kinase A stimulation of a stretch-activated cation channel in renal epithelial A6 cells, Biochem. Pharmacol. 61 (2001) 761-765.
37. P. Estess, A. Nandi, M. Mohamadzadeh, M.H. Siegelman, Interleukin 15 induces endothelial hyaluronan expression in vitro and promotes activated T cell extravasation through a CD44-dependent pathway in vivo, J. Exp. Med. 190 (1999) 9-19.
38. M. Li, L. Rosenfeld, R.E. Vilar, M.K. Cowman, Degradation of hyaluronan by peroxynitrite, Arch. Biochem. Biophys. 341 (1997) 245-250.