메뉴 건너뛰기




Volumn 90, Issue 3, 2005, Pages 296-298

Why do humans need two types of transferrin receptor? Lessons from a rare genetic disorder

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN 1; IRON REGULATORY PROTEIN 2; TRANSFERRIN RECEPTOR;

EID: 15244339138     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial
Times cited : (7)

References (37)
  • 1
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004; 117:285-97.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 2
    • 0031783567 scopus 로고    scopus 로고
    • Large-scale sequencing of two regions in human chromosome 7q22: Analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes
    • Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, et al. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. Genome Res 1998;8:1060-73.
    • (1998) Genome Res , vol.8 , pp. 1060-1073
    • Glockner, G.1    Scherer, S.2    Schattevoy, R.3    Boright, A.4    Weber, J.5    Tsui, L.C.6
  • 3
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
    • Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 1999;274:20826-35.
    • (1999) J Biol Chem , vol.274 , pp. 20826-20835
    • Kawabata, H.1    Yang, R.2    Hirama, T.3    Vuong, P.T.4    Kawano, S.5    Gombart, A.F.6
  • 4
    • 13144282684 scopus 로고    scopus 로고
    • The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    • Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 1998;95:1472-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1472-1477
    • Feder, J.N.1    Penny, D.M.2    Irrinki, A.3    Lee, V.K.4    Lebron, J.A.5    Watson, N.6
  • 5
    • 0034595856 scopus 로고    scopus 로고
    • Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo
    • Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-α supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem 2000;275:16618-25.
    • (2000) J Biol Chem , vol.275 , pp. 16618-16625
    • Kawabata, H.1    Germain, R.S.2    Vuong, P.T.3    Nakamaki, T.4    Said, J.W.5    Koeffler, H.P.6
  • 6
    • 0034007995 scopus 로고    scopus 로고
    • Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
    • Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA. 2000;97:2214-9.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , pp. 2214-2219
    • Fleming, R.E.1    Migas, M.C.2    Holden, C.C.3    Waheed, A.4    Britton, R.S.5    Tomatsu, S.6
  • 7
    • 0032959574 scopus 로고    scopus 로고
    • Transferrin receptor is necessary for development of erythrocytes and the nervous system
    • Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 1999;21:396-9.
    • (1999) Nat Genet , vol.21 , pp. 396-399
    • Levy, J.E.1    Jin, O.2    Fujiwara, Y.3    Kuo, F.4    Andrews, N.C.5
  • 10
    • 0037111572 scopus 로고    scopus 로고
    • Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
    • Deaglio S, Capobianco A, Cali A, Bellora F, Alberti F, Righi L, et al. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood 2002;100:3782-9.
    • (2002) Blood , vol.100 , pp. 3782-3789
    • Deaglio, S.1    Capobianco, A.2    Cali, A.3    Bellora, F.4    Alberti, F.5    Righi, L.6
  • 11
    • 0037406254 scopus 로고    scopus 로고
    • Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells
    • Griffiths WJ, Cox TM. Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J Histochem Cytochem 2003;51:613-24.
    • (2003) J Histochem Cytochem , vol.51 , pp. 613-624
    • Griffiths, W.J.1    Cox, T.M.2
  • 12
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 2000; 275:38135-8.
    • (2000) J Biol Chem , vol.275 , pp. 38135-38138
    • West Jr., A.P.1    Bennett, M.J.2    Sellers, V.M.3    Andrews, N.C.4    Enns, C.A.5    Bjorkman, P.J.6
  • 13
    • 0042062322 scopus 로고    scopus 로고
    • Molecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemia
    • Kollia P, Samara M, Stamatopoulos K, Belessi C, Stavroyanni N, Tsompanakou A, et al. Molecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemia. Leuk Res 2003;27:1101-3.
    • (2003) Leuk Res , vol.27 , pp. 1101-1103
    • Kollia, P.1    Samara, M.2    Stamatopoulos, K.3    Belessi, C.4    Stavroyanni, N.5    Tsompanakou, A.6
  • 16
    • 0035046436 scopus 로고    scopus 로고
    • Transferrin receptor-2 (TFR2) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overload
    • Barton EH, West PA, Rivers CA, Barton JC, Acton RT. Transferrin receptor-2 (TFR2) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overload. Blood Cells Mol Dis 2001;27:279-84.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 279-284
    • Barton, E.H.1    West, P.A.2    Rivers, C.A.3    Barton, J.C.4    Acton, R.T.5
  • 17
    • 0035049344 scopus 로고    scopus 로고
    • Mutation analysis in the transferring receptor 2 gene in patients with iron overload
    • Lee PL, Halloran C, West C, Beutler E. Mutation analysis in the transferring receptor 2 gene in patients with iron overload. Blood Cell Mol Dis 2001;27:285-9.
    • (2001) Blood Cell Mol Dis , vol.27 , pp. 285-289
    • Lee, P.L.1    Halloran, C.2    West, C.3    Beutler, E.4
  • 18
    • 0035353167 scopus 로고    scopus 로고
    • New mutations inactivating transferrin receptor 2 in hemochromatosis type 3
    • Roetto A, Totaro A, Piperno A, Piga A, Longo F, Garozzo G, et al. New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood 2001;97:2555-60.
    • (2001) Blood , vol.97 , pp. 2555-2560
    • Roetto, A.1    Totaro, A.2    Piperno, A.3    Piga, A.4    Longo, F.5    Garozzo, G.6
  • 19
    • 0036242163 scopus 로고    scopus 로고
    • Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene
    • Girelli D, Bozzini C, Roetto A, Alberti F, Daraio F, Colombari R, et al. Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene. Gastroenterology 2002;122: 1295-302.
    • (2002) Gastroenterology , vol.122 , pp. 1295-1302
    • Girelli, D.1    Bozzini, C.2    Roetto, A.3    Alberti, F.4    Daraio, F.5    Colombari, R.6
  • 20
    • 1942445099 scopus 로고    scopus 로고
    • Homozygosity for transferrin receptor-2 Y250X mutation induces early iron overload
    • Piperno A, Roetto A, Mariani R, Pelucchi S, Corengia C, Daraio F, et al. Homozygosity for transferrin receptor-2 Y250X mutation induces early iron overload. Haematologica 2004; 89:359-60.
    • (2004) Haematologica , vol.89 , pp. 359-360
    • Piperno, A.1    Roetto, A.2    Mariani, R.3    Pelucchi, S.4    Corengia, C.5    Daraio, F.6
  • 21
    • 0344514886 scopus 로고    scopus 로고
    • Identification or new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload
    • Biasiotto G, Belloli S, Ruggeri G, Zanella I, Gerardi G, Corrado M, et al. Identification or new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload. Clin Chem 2003;49:1981-8.
    • (2003) Clin Chem , vol.49 , pp. 1981-1988
    • Biasiotto, G.1    Belloli, S.2    Ruggeri, G.3    Zanella, I.4    Gerardi, G.5    Corrado, M.6
  • 22
    • 0036683019 scopus 로고    scopus 로고
    • Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: Identification of a novel TfR2 mutation
    • Mattman A, Huntsman D, Lockitch G, Langlois S, Buskard N, Ralston D, et al. Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation. Blood 2002;100:1075-7.
    • (2002) Blood , vol.100 , pp. 1075-1077
    • Mattman, A.1    Huntsman, D.2    Lockitch, G.3    Langlois, S.4    Buskard, N.5    Ralston, D.6
  • 23
    • 2942582341 scopus 로고    scopus 로고
    • Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent
    • Le Gac G, Mons F, Jacolot S, Scotet V, Ferec C, Frebourg T. Early onset hereditary hemochromatosis resulting from a novel TFR2 gene nonsense mutation (R105X) in two siblings of north French descent. Br J Haematol 2004;125:674-8.
    • (2004) Br J Haematol , vol.125 , pp. 674-678
    • Le Gac, G.1    Mons, F.2    Jacolot, S.3    Scotet, V.4    Ferec, C.5    Frebourg, T.6
  • 26
    • 0034881731 scopus 로고    scopus 로고
    • Hemochromatosis with HFE gene mutation in a Japanese patient
    • Sohda T, Okubo R, Kamimura S, Ohkawara T. Hemochromatosis with HFE gene mutation in a Japanese patient. Am J Gastroenterol 2001;96:2487-8.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2487-2488
    • Sohda, T.1    Okubo, R.2    Kamimura, S.3    Ohkawara, T.4
  • 27
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-8.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 28
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3    Alberti, F.4    Girelli, D.5    Christakis, J.6
  • 30
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003; 361:669-73.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3    Dixon, J.L.4    Purdie, D.M.5    Crawford, D.H.6
  • 31
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    • Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003;102:371-6.
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3    Riedel, H.D.4    Bents, K.5    Veltkamp, C.6
  • 32
    • 19944427107 scopus 로고    scopus 로고
    • Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    • Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'kelly J, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005;105:376-81.
    • (2005) Blood , vol.105 , pp. 376-381
    • Kawabata, H.1    Fleming, R.E.2    Gui, D.3    Moon, S.Y.4    Saitoh, T.5    O'Kelly, J.6
  • 34
    • 10244265904 scopus 로고    scopus 로고
    • Regulation of transferrin receptor 2 by transferrin: Diferric transferrin regulates transferrin receptor 2 protein stability
    • Johnson MB, Enns CA. Regulation of transferrin receptor 2 by transferrin: diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004;104:4287-93.
    • (2004) Blood , vol.104 , pp. 4287-4293
    • Johnson, M.B.1    Enns, C.A.2
  • 35
    • 10244255021 scopus 로고    scopus 로고
    • Regulation of transferrin receptor 2 protein levels by transferrin
    • Robb A, Wessling-Resnick M.Regulation of transferrin receptor 2 protein levels by transferrin. Blood 2004;104:4294-9.
    • (2004) Blood , vol.104 , pp. 4294-4299
    • Robb, A.1    Wessling-Resnick, M.2
  • 36
    • 0037370747 scopus 로고    scopus 로고
    • Heterotypic interactions between transferrin receptor and transferrin receptor 2
    • Vogt TM, Blackwell AD, Giannetti AM, Bjorkman PJ, Enns CA. Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 2003;101:2008-14.
    • (2003) Blood , vol.101 , pp. 2008-2014
    • Vogt, T.M.1    Blackwell, A.D.2    Giannetti, A.M.3    Bjorkman, P.J.4    Enns, C.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.