Rolipram, salbutamol and prostaglandin E2 suppress TNFα release from human monocytes by activating Type II cAMP-dependent protein kinase

Pulmonary Pharmacology and Therapeutics

Volumn 18, Issue 4, 2005, Pages 277-284

  Seldon, Paul M ^a   Meja, Koremu K ^b   Giembycz, Mark A ^c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NOVARTIS HORSHAM RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

cAMP dependent protein kinase; cAMP GEF; Monocyte; TNF

Indexed keywords

8 BROMO CYCLIC AMP; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE 1; CYCLIC AMP DEPENDENT PROTEIN KINASE 2; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOKINE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOENZYME; LIPOPOLYSACCHARIDE; PHOSPHOTRANSFERASE; PROSTAGLANDIN E2; PROSTAGLANDIN E4 INHIBITOR; PROSTAGLANDIN INHIBITOR; PROTEIN; RAP1 PROTEIN; ROLIPRAM; SALBUTAMOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MONOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; STIMULATION;

EID: 15044350769     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pupt.2004.12.012     Document Type: Article

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