Giving a Nod2 the right target

Scientist

Volumn 19, Issue 3, 2005, Pages 24-25

  Constans, Aileen ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; LEUCINE; LIPOPOLYSACCHARIDE; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL INFECTION; CROHN DISEASE; DOWN REGULATION; ENTERITIS; GENE MUTATION; GRAM NEGATIVE SEPSIS; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNITY; INTESTINE ABSORPTION; MEDICAL RESEARCH; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 15044342283     PISSN: 08903670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. J. Roberts, "An immunological role in the CARDs," The Scientist, 17[20]:29, Oct. 20, 2003.
2. N. Inohara et al., "Host recognition of bacterial muramyl dipeptide mediated through Nod2,"J Biol Chem, 278:5509-12, 2003. (Cited in 115 papers)
3. S.E. Girardin et al., "Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection," J Biol Chem, 278:8869-72, 2003. (Cited in 113 papers)
4. J. Viala et al., "Nodi responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island," Nat Immunol, 5:1166-74, November 2004.
5. T. Watanabe et al., "Nod2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses," Nat Immunol, 5:800-8, August 2004.
6. F. Martinon et al., "Identification of bacterial muramyl dipeptide as activator of the NALP3/Cryopyrin inflammasome," Curr Biol, 14:1929-34, Nov. 9, 2004.
7. S.R. Vavricka et al., "hPepT1 transports muramyl dipeptide, activating NF-κB and stimulating IL-8 secretion in human colonic Caco2/bbe cells," Gastroenterology, 127:1401-9, November 2004.
8. J. Wehkamp et al., "NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression," Gut, 53:1658-64, November 2004.
9. S. Maeda et al., "NOD2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing," Science, 307:734-8, Feb. 4, 2005.
10. K.S. Kobayashi et al., "Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract," Science, 307:731-4, Feb. 4, 2005.