Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1543-1547

  Sad, Subash ^a   Kägi, David ^b   Mosmann, Tim R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; PERFORIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HELPER CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD95; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029956511     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1543     Document Type: Article

References (34)

1. Allison, J.P. 1994. CD28-B7 interactions in T-cell activation. Curr. Opin. Immunol. 6:414-419.
2. Stout, R.D., and K. Bottomly. 1989. Antigen-specific activation of effector macrophages by IFN-γ-producing (TH1) T cell clones. Failure of IL4-producing (TH2) T cell clones to activate effector function in macrophages. J. Immunol. 142:760-765.
3. Vitetta, E.S., R. Fernandez-Botran, C.D. Myers, and V.M. Sanders. 1989. Cellular interactions in the humoral immune response. Adv. Immunol. 45:1-106.
4. Swoboda, R., U. Bommhardt, and A. Schimpl. 1991. Regulation of lymphokine expression in T cell activation. I. Rapid loss of interleukin-specific RNA after removal of the stimulating signal. Eur. J. Immunol. 21:1691-1695.
5. + T cells to cell proliferation and cytolytic activity. J. Exp. Med. 148:1523-1538.
6. Nabholz, M., H.D. Engers, D. Collavo, and M. North. 1978. Cloned T-cell lines with specific cytolytic activity. Curr. Top. Microbiol. Immunol. 81:176-187.
7. Glasebrook, A.L., and F.W. Fitch. 1979. T-cell lines which cooperate in generation of specific cytolytic activity. Nature (Lond.). 278:171-173.
8. von Boehmer, H., H. Hengartner, M. Nabholz, W. Lernhardt, M.H. Schreier, and W. Haas. 1979. Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Eur. J. Immunol. 9:592-597.
9. Gillis, S., and K.A. Smith. 1977. Long term culture of tumour-specific cytotoxic T cells. Nature (Lond.). 268:154-156.
10. Widmer, M.B., and F.H. Bach. 1981. Antigen-driven helper cell-independent cloned cytolytic T lymphocytes. Nature (Lond.). 294:750-752.
11. von Boehmer, H., and K. Turton. 1983. Autonomously proliferating K/D-restricted cytolytic T cell clones. Eur. J. Immunol. 13:176-179.
12. Wee, S.L., L.K. Chen, G. Strassmann, and F.H. Bach. 1982. Helper cell-independent cytotoxic clones in man. J. Exp. Med. 156:1854-1859.
13. Croft, M., L. Carter, S.L. Swain, and R.W. Dutton. 1994. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J. Exp. Med. 180:1715-1728.
14. + T cell clones secrete the Th1 pattern of cytokines. J. Immunol. 144:1744-1752.
15. + cells secreting TH1 or TH2 cytokines. Immunity. 2:271-279.
16. Zinkernagel, R.M. 1996. Immunology taught by viruses. Science (Wash. DC). 271:173-178.
17. Glimcher, L.H., S.O. Sharrow, and W.E. Paul. 1983. Serologic and functional characterization of a panel of antigen-presenting cell lines expressing mutant I-A class II molecules. J. Exp. Med. 158:1573-1588.
18. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195-200.
19. + Tc1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J. Exp. Med. 182:1505-1515.
20. Mosmann, T.R., and T.A. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods. 116:151-158.
21. Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348-2357.
22. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (Lond.). 369:31-37.
23. Walsh, C.M., M. Matloubian, C.C. Liu, R. Ueda, C.G. Kurahara, J.L. Christensen, M.T. Huang, J.D. Young, R. Ahmed, and W.R. Clark. 1994. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. USA. 91: 10854-10858.
24. Kojima, H., N. Shinohara, S. Hanaoka, Y. Someya-Shirota, Y. Takagaki, H. Ohno, T. Saito, T. Katayama, H. Yagita, K. Okumura, et al., 1994. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity. 1:357-364.
25. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature (Lond.). 370:650-652.
26. Kagi, D., F. Vignaux, B. Ledermann, K. Burki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science (Wash. DC). 265:528-530.
27. Rothstein, T.L., J.K. Wang, D.J. Panka, L.C. Foote, Z. Wang, B. Stanger, H. Cui, S.T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature (Lond.). 374:163-165.
28. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med 183:1917-1921.
29. Kagi, D., P. Seiler, J. Pavlovic, B. Ledermann, K. Burki, R.M. Zinkernagel, and H. Hengartner. 1995. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur. J. Immunol. 25: 3256-3262.
30. Harty, J.T., R.D. Schreiber, and M.J. Bevan. 1992. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc. Natl. Acad. Sci. USA. 89:11612-11616.
31. + cells after a transient response to antigen. Eur. J. Immunol. 23:1963-1967.
32. a by exposure to alloantigen in the absence of T-cell help. Proc. Natl. Acad. Sci. USA. 87:2765-2769.
33. + cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056-8063.
34. + T cells. J. Virol. 64:4589-4592.