Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7- trimethyluric acid formation) of caffeine in wistar and dark agouti rats: Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats

Biochemical Pharmacology

Volumn 55, Issue 9, 1998, Pages 1405-1411

  Morita, Keiichi ^a   Maeda, Yutaka ^a   Masuda, Makihiko ^b   Kazusaka, Akio ^a   Imaoka, Susumu ^c   Funae, Yoshihiko ^c   Fujita, Shoichi ^a  

^a Laboratory of Toxicology   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Caffeine metabolism; CYP3A; Cytochrome P450; Dark Agouti rats

Indexed keywords

CAFFEINE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DEBRISOQUINE; DRUG METABOLITE; OXYGENASE; PARAXANTHINE; THEOBROMINE; THEOPHYLLINE; TROLEANDOMYCIN; URIC ACID DERIVATIVE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HYDROXYLATION; IMMUNOBLOTTING; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STRAIN DIFFERENCE;

AGING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CAFFEINE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEBRISOQUIN; DEXAMETHASONE; FEMALE; HUMANS; HYDROXYLATION; MALE; METHYLCHOLANTHRENE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; PREGNENOLONE CARBONITRILE; RATS; RATS, WISTAR; SEX CHARACTERISTICS; SPECIES SPECIFICITY; TROLEANDOMYCIN; URIC ACID;

EID: 0032499416     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00654-0     Document Type: Article

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