Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice

Immunology

Volumn 114, Issue 3, 2005, Pages 428-437

  Hansson, Monika ^a   Djerbi, Mounira ^a   Rabbani, Hodjattallah ^b   Mellstedt, Håkan ^b   Gharibdoost, Farhad ^c   Hassan, Moustapha ^b   DePierre, Joseph W ^d   Abedi Valugerdi, Manuchehr ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Autoimmunity; Collagen induced arthritis; DBA 1 mice; Mercuric chloride; Th1 Th2 cytokines

Indexed keywords

ANTINUCLEAR ANTIBODY; COLLAGEN; COLLAGEN TYPE 2; GAMMA INTERFERON; HEAVY METAL; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; INTERLEUKIN 4; MERCURIC CHLORIDE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SPLEEN; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; COLLAGEN TYPE II; FEMALE; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; MERCURIC CHLORIDE; MICE; MICE, INBRED DBA; RNA, MESSENGER; SPLEEN;

EID: 14644431761     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2005.02105.x     Document Type: Article

References (39)

1. Sweet LI, Zelikoff JT. Toxicology and immunotoxicology of mercury, a comparative review in fish and humans. J Toxicol Environ Health B Crit Rev 2001; 4:161-205.
2. Moszczynski P. Mercury compounds and the immune system: a review. Int J Occup Med Environ Health 1997; 10:247-58.
3. Bagenstose LM, Salgame P, Monestier M. Murine mercury-induced autoimmunity: a model of chemically related autoimmunity in humans. Immunol Res 1999; 20:67-78.
4. Griem P, Gleichmann E. Metal ion induced autoimmunity. Curr Opin Immunol 1995; 7:831-8.
5. Bagenstose LM, Salgame P, Monestier M. Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity. Environ Health Perspect 1999; 107 (Suppl. 5):807-10.
6. Fournie GJ, Mas M, Cautain B et al. Induction of autoimmunity through bystander effects. Lessons from immunological disorders induced by heavy metals. J Autoimmun 2001; 16:319-26.
7. Hultman P, Enestrom S. Mercury induced B-cell activation and antinuclear antibodies in mice. J Clin Lab Immunol 1989; 28:143-50.
8. Hultman P, Johansson U, Dagnaes-Hansen F. Murine mercury-induced autoimmunity, the role of T-helper cells. J Autoimmun 1995; 8:809-23.
9. Robinson CJ, Abraham AA, Balazs T. Induction of anti-nuclear antibodies by mercuric chloride in mice. Clin Exp Immunol 1984; 58:300-6.
10. Hultman P, Enestrom S. Murine mercury-induced immune-complex disease: effect of cyclophosphamide treatment and importance of T-cells. Br J Exp Pathol 1989; 70:227-36.
11. Hultman P, Bell LJ, Enestrom S, Pollard KM. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin Immunol Immunopathol 1992; 65:98-109.
12. Abedi-Valugerdi M, Moller G. Contribution of H-2 and non-H-2 genes in the control of mercury-induced autoimmunity. Int Immunol 2000; 12:1425-30.
13. Abedi-Valugerdi M, Hansson M, Moller G. Genetic control of resistance to mercury-induced immune/autoimmune activation. Scand J Immunol 2001; 54:190-7.
14. Kono DH, Park MS, Szydlik A, Haraldsson KM, Kuan JD, Pearson DL, Hultman P, Pollard KM. Resistance to xenobiotic-induced autoimmunity maps to chromosome 1. J Immunol 2001; 167:2396-403.
15. Haggqvist B, Hultman P. Murine metal-induced systemic autoimmunity, baseline and stimulated cytokine mRNA expression in genetically susceptible and resistant strains. Clin Exp Immunol 2001; 126:157-64.
16. Theofilopoulos AN. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol Today 1995; 16:90-8.
17. Theofilopoulos AN. The basis of autoimmunity: Part II. Genetic predisposition. Immunol Today 1995; 16:150-9.
18. Ermann J, Fathman CG. Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol 2001; 2:759-61.
19. al-Balaghi S, Moller E, Moller G, Abedi-Valugerdi M. Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB x NZW) F1 hybrids. Eur J Immunol 1996; 26:1519-26.
20. Hansson M, Abedi-Valugerdi M. Mercuric chloride induces a strong immune activation, but does not accelerate the development of dermal fibrosis in tight skin 1 mice. Scand J Immunol 2004; 59:469-77.
21. Pollard KM, Pearson DL, Hultman P, Deane TN, Lindh U, Kono DH. Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice. Environ Health Perspect 2001; 109:27-33.
22. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature 1980; 283:666-8.
23. Luross JA, Williams NA. The genetic and immunopathological processes underlying collagen-induced arthritis. Immunology 2001; 103:407-16.
24. Myers LK, Rosloniec EF, Cremer MA, Kang AH. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci 1997; 61:1861-78.
25. Brand DD, Kang AH, Rosloniec EF. Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol 2003; 25:3-18.
26. Gronowicz E, Coutinho A, Melchers F. A plaque assay for all cells secreting Ig of a given type or class. Eur J Immunol 1976; 6:588-90.
27. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res 1996; 6:986-94.
28. Brenden N, Rabbani H, Abedi-Valugerdi M. Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice. Clin Exp Immunol 2001; 125:202-10.
29. Via CS, Nguyen P, Niculescu F, Papadimitriou J, Hoover D, Silbergeld EK. Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus. Environ Health Perspect 2003; 111:1273-7.
30. Zdolsek JM, Söder O, Hultman P. Mercury induces in vivo and in vitro secretion of interleukin-1 in mice. Immunopharmacology 1994; 28:201-8.
31. Johansson U, Sander B, Hultman P. Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun 1997; 10:347-55.
32. Marcelletti JF, Ohara J, Katz DH. Collagen-induced arthritis in mice. Relationship of collagen-specific and total IgE synthesis to disease. J Immunol 1991; 147:4185-91.
33. 2 in the rat. J Immunol 1981; 126:699-792.
34. Svensson L, Jirholt J, Holmdahl R, Jansson L. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol 1998; 111:521-6.
35. Watzl B, Abrahamse SL, Treptow-van Lishaut S, Neudecker C, Hansch GM, Rechkemmer G, Pool-Zobel BL. Enhancement of ovalbumin-induced antibody production and mucosal mast cell response by mercury. Food Chem Toxicol 1999; 37:627-37.
36. Roether S, Rabbani H, Mellstedt H, Abedi-Valugerdi M. Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression. Scand J Immunol 2002; 55:493-502.
37. Kono DH, Balomenos D, Pearson DL, Park MS, Hildebrandt B, Hultman P, Pollard KM. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol 1998; 16:234-40.
38. Zhang Y, Apilado R, Coleman J, Ben-Sasson S, Tsang S, Hu-Li J, Paul WE, Huang H. Interferon gamma stabilizes the T helper cell type 1 phenotype. J Exp Med 2001; 194:165-72.
39. Hultman P, Turley SJ, Eneström S, Lindh U, Pollard KM. Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmun 1996; 9:139-49.