Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice

Clinical and Experimental Immunology

Volumn 125, Issue 2, 2001, Pages 202-210

  Brenden, N ^a   Rabbani, H ^b   Abedi Valugerdi, M ^c  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Autoantibodies; Cytokines; Diabetes; In vivo animal models; Th1 Th2 cells

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G1; INSULIN; INTERLEUKIN 4; MERCURY; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DIABETES MELLITUS; DNA SYNTHESIS; FEMALE; GENE EXPRESSION; GLOMERULUS; IMMUNE RESPONSE; IMMUNOGLOBULIN DEPOSITION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; B-LYMPHOCYTES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; INTERFERON TYPE II; INTERLEUKIN-4; KIDNEY; KINETICS; LYMPHOCYTE ACTIVATION; MERCURY; MICE; MICE, INBRED NOD; RNA, MESSENGER; SPLEEN; TH2 CELLS;

EID: 0034891153     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01580.x     Document Type: Article

References (45)

1. Type-I Diabetes: A chronic autoimmune disease of human, mouse and rat
2. The murine autoimmune diabetes model: NOD and related strains
3. Contribution of T cells to the development of autoimmune diabetes in the NOD mouse model
4. From genome to aetiology in a multifactorial disease, type 1 diabetes
5. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
6. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
7. The Th1/Th2 balance in autoimmunity
8. Th2 cells in systemic autoimmunity: Insights from allogeneic diseases and chemically-induced autoimmunity
9. Metal ion induced autoimmunity
10. Does amalgam affect the immune system? A controversial issue
11. Induction of anti-nuclear antibodies by mercuric chloride in mice
12. Mercury induced B-cell activation and antinuclear antibodies in mice
13. Murine mercury-induced immune-complex disease: Effect of cyclophosphamide treatment and importance of T cells
14. Murine mercury-induced autoimmunity: The role of T-helper cells
15. 2-induced antinucleolar autoantibodies
16. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic and intra-H-2 recombinant strains
17. Murine susceptibility to mercury. II. Autoantibody profiles and renal immune deposits in hybrid, backcross, and H-2d congenic mice
18. Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity
19. 2-treated mice
20. Contribution of H-2 and non-H-2 genes in the control of mercury-induced autoimmunity
21. Mercury: God of Th2 cells
22. A plaque assay for all cells secreting Ig of a given type or class
23. Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB × NZW) F1 hybrids
24. Real time quantitative PCR
25. Mechanism of mercury-induced autoimmunity: Both T helper 1- and T helper 2-type responses are involved
26. Regulation of IgG1 and IgE production by interleukin 4
27. Lymphokine control of in vivo immunoglobulin isotype selection
28. IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride
29. The NOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
30. The first external domain of the nonobese diabetic mouse class II, I-A b chain is unique
31. Mercury induced antinuclear antibodies in mice: Characterization and correlation with renal immune complex deposits
32. Mercury-induced renal immune complex deposits in young (NZB × NZW) F1 mice: Characterization of antibodies/autoantibodies
33. Th1/Th2 cytokine gene expression after mercury chloride in susceptible and resistant rat strains
34. The prototype Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th/Th2 imbalance
35. The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice
36. Down regulation of Hemann's nephritis by mercuric chloride
37. 2-induced down-regulation of the disease
38. 2 injections
39. Enhancement of Th2-type activity downregulated diabetes induction
40. Transforming growth factor β (TGF-β)-dependent inhibition of T Helper cell 2 (Th2) -induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4+ T cell lines
41. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease
42. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in non-obese diabetic mice by potentiation of regulatory T helper-2 cell function
43. Insulin dependent diabete mellitus in the non-obese diabetic mouse: A disease mediated by T cell anergy?
44. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
45. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice