Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression

Scandinavian Journal of Immunology

Volumn 55, Issue 5, 2002, Pages 493-502

  Roether, S ^a,b   Rabbani, H ^c   Mellstedt, H ^c   Abedi Valugerdi, M ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF BAYREUTH   (Germany)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MERCURIC CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; AUTOREGULATION; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; ERYTHROCYTE; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; LONG TERM EXPOSURE; MOUSE; MOUSE STRAIN; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; DOWN-REGULATION; ERYTHROCYTES; FEMALE; HORSES; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; KIDNEY GLOMERULUS; MERCURIC CHLORIDE; MICE; MICE, INBRED DBA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN;

EID: 0036254261     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2002.01085.x     Document Type: Article

References (36)

1. TH2 cells in systemic autoimmunity: Insights from allogeneic disease and chemically-induced autoimmunity
2. Metal ion induced autoimmunity
3. Does amalgam affect the immune system? A controversial issue
4. 2 in the rat, its possible role in an experimental autoimmune disease
5. Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the brown Norway rat
6. Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB x NZW) F1 hybrids
7. Mercury induced B-cell activation and antinuclear antibodies in mice
8. Mercuric chloride-induced autoimmunity
9. Mercury: God of Th2 cells?
10. 2 in the brown Norway rat
11. Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression
12. Circulating and tissue immune complexes in mercury-treated mice
13. IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride
14. Interleukin-4 gene expression in mercury-induced autoimmunity
15. Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains
16. Immunological alterations inducible by mercury compounds. II. HgCl2 and gold sodium thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains
17. MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride
18. Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the brown Norway rat. I. A role for T suppressor cells
19. Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the brown Norway rat. II. Presence of antigen-augmentable plaque-forming cells in the spleen is associated with humoral factors behaving as autoanti-idiotypic antibodies
20. + T cells revealed by in vivo depletion studies
21. + T cells in mercury-induced autoimmunity or immunosuppression in the rat
22. Immunotoxicology of cadmium and mercury on B-lymphocytes. I. Effects on lymphocyte function
23. Inhibition of lymphoid cell DNA synthesis by metal allergens at various concentrations. Effect on short-time cultured nonadherent cells compared to nonseparated cells
24. Effect of mercurials on lymphocyte functions in vitro
25. A plaque assay for all cells secreting Ig of a given type or class
26. An enzymelinked immunosorbent assay for measuring anti-sheep erythrocyte antibodies
27. Real time quantitative PCR
28. Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice
29. Mercuric chloride induced autoimmune disease in brown-Norway rats: Sequential search for anti-basement membrane antibodies and circulating immune complexes
30. The influence of I-E on the generation of autoantibody and specific suppression in rat erythrocyte-immunized mice
31. Mercury induced antinuclear antibodies in mice: Characterization and correlation with renal immune complex deposits
32. Methylmercury: Decreased antibody formation in mice
33. Methylmercury: Effect on serum enzymes and humoral antibody
34. Some immunological effects of lead, cadmium and methylmercury
35. Methyl mercury-induced autoimmunity in mice
36. Regulatory T cells in the control of immune pathology