Recent findings in the cell and molecular biology of the small intestine

Current Opinion in Gastroenterology

Volumn 21, Issue 2, 2005, Pages 135-140

  Walters, Julian R F ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Development; Duodenum; Enterocyte; Gene expression; Goblet cell; Ileum; Jejunum; Mucosa; Paneth cell

Indexed keywords

APC; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 15; BONE MORPHOGENETIC PROTEIN 4; CALCIUM BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME P450 1A1; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B3; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HERMES ANTIGEN; KI 67 ANTIGEN; MUCIN 2; MYC PROTEIN; NUCLEAR FACTOR I; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMAD4 PROTEIN; SONIC HEDGEHOG PROTEIN; T CELL FACTOR PROTEIN; TATA BINDING PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

AUTOCRINE EFFECT; CELL INTERACTION; CELL PROLIFERATION; CRYPT CELL; DNA MICROARRAY; GENE EXPRESSION; HOMEOSTASIS; INNATE IMMUNITY; INTESTINE MUCOSA; INTESTINE VILLUS; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; REVIEW; SMALL INTESTINE; STEM CELL; TRANSCRIPTION INITIATION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS;

EID: 14644428982     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mog.0000153309.13080.8b     Document Type: Review

References (37)

1. Pinto D, Gregorieff A, Begthel H, Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev 2003; 17:1709-1713. A detailed study of the changes in small intestine when Wnt signaling is suppressed by expression of the Wnt inhibitor Dickkopf-1 in transgenic mice.
2. Kuhnert F, Davis CR, Wang HT, et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA 2004; 101:266-271. Another superlative investigation of the disordered small intestinal architepture resulting from Wnt inhibition by adenoviral expression of Dickkopf-1.
3. Sansom OJ, Reed KR, Hayes AJ, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 2004; 18:1385-1390. An extensive study detailing the effects on cell function and gene expression of activation of the Wnt pathway by conditional deletion of APC.
4. Ireland H, Kemp R, Houghton C, et al. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: Effect of loss of β-catenin. Gastroenterology 2004; 126:1236-1246.
5. Blache P, Van De Wetering M, Duluc I, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol 2004; 166:37-47. A new transcription factor in intestinal physiology, SOX9, is thoroughly studied.
6. Guo RJ, Huang E, Ezaki T, et al. Cdx1 inhibits human colon cancer cell proliferation by reducing β-catenin/T-cell factor transcriptional activity. J Biol Chem 2004; 279:36865-36875. Interactions of the CDX factors with the Wnt pathway.
7. Morkel M, Huelsken J, Wakamiya M, et al. β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 2003; 130:6283-6294.
8. Gregorieff A, Grosschedl R, Clevers H. Hindgut defects and transformation of the gastrointestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J 2004; 23:1825-1833. Developmental changes of the intestinal tract with deletion of two key transcription factors.
9. Cebrat M, Strzadala L, Kisielow P. Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cancer Lett 2004; 206:107-113.
10. Ouko L, Ziegler TR, Gu LH, et al. Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. J Biol Chem 2004; 279:26707-26715.
11. Blaker H, Helmchen B, Bonisch A, et al. Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas. Scand J Gastroenterol 2004; 39:748-753. Reports of changes in small intestinal tumours.
12. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425:846-851. Hedgehog is important in the development of many gastrointestinal tumours.
13. Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 245:851-856.
14. van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004; 36:277-282. Interactions of Hedgehog and Wnt pathways in intestinal cells.
15. Qualtrough D, Buda A, Gaffield W, et al. Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment. Int J Cancer 2004; 110:831-837.
16. Van Eyll JM, Pierreux CE, Lemaigre FP, Rousseau GG. Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A. J Cell Sci 2004; 117:2077-2086. A demonstration of how Hedgehog signals promote intestinal differentiation.
17. Hardwick JCH, van den Brink GR, Bleuming SA, et al. Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology 2004; 126:111-121.
18. Haramis APG, Begthel H, Van Den Born M, et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004; 303:1684-1686. Beautiful results obtained by transgenic expression of the BMP inhibitor Noggin show the interaction of mesenchymal and epithelial cells to produce intestinal polyposis.
19. He XC, Zhang J, Tong W-G, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nat Genet 2004; 36:1117-1121. A complex and detailed description of how the BMP and Wnt pathways interact to regulate duplication of intestinal stem cells.
20. Gautier-Stein A, Domon-Dell C, Calon A, et al. Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2. Nucleic Acids Res 2003; 31:5238-5246. Different effects of two key intestinal transcription factors.
21. Lynch J, Keller M, Guo RJ, et al. Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. Oncogene 2003; 22:6395-6407.
22. Rankin EB, Xu W, Silberg DG, Suh E. Putative intestine-specific enhancers located in 5′ sequence of the CDX1 gene regulate CDX1 expression in the intestine. Am J Physiol Gastrointest Liver Physiol 2004; 286:G872-G880.
23. Uesaka T, Kageyama N, Watanabe H. Identifying target genes regulated downstream of Cdx2 by microarray analysis. J Mol Biol 2004; 337:647-660. An important study of genes affected by CDX2.
24. Wang L, Klopot A, Freund J-N, et al. Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx2 and HNF-1α. Am J Physiol Gastrointest Liver Physiol 2004; 287:G943-G953. A specific example of how these two transcription factors regulate different aspects of intestinal gene expression.
25. Gregory PA, Lewinsky RH, Gardner-Stephen DA, Mackenzie PI. Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2. Mol Pharmacol 2004; 65:953-963.
26. Mesquita P, Jonckheere N, Almeida R, et al. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003; 278:51549-51556.
27. Uesaka T, Kageyama N. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. FEBS Lett 2004; 573:147-154.
28. Mouchel N, Henstra SA, McCarthy VA, et al. HNF1 alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J 2004; 378:909-918.
29. Sakai H, Eishi Y, Li XL, et al. PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut 2004; 53:323-330.
30. Wang Z, Fang RX, Olds LC, Sibley E. Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. Am J Physiol Gastrointest Liver Physiol 2004; 287:G555-G561. A factor that may define the anterior boundary of small intestinal gene expression.
31. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003;21. A review of these topical components of the innate immune response system.
32. Lala S, Ogura Y, Osborne C, et al. Crohn's disease and the NOD2 gene: a role for Paneth cells. Gastroenterology 2003; 125:47-57. The Toll-like receptor associated with Crohn's is most abundant in the epithelial Paneth cell.
33. Ogura Y, Lala S, Xin W, et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 2003; 52:1591-1597.
34. Otte JM, Rosenberg IM, Podolsky DK. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003; 124:1866-1878. Other intestinal cells express different Toll-like receptors.
35. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004; 118:229-241. Removal of MyD88, the adaptor essential for Toll-like receptor functioning, increased sensitivity to intestinal injury.
36. Bashir ME, Louie S, Shi HN, Nagler-Anderson C. Toll-like receptor 4 signalling by intestinal microbes influences susceptibility to food allergy. J Immunol 2004; 172:6978-6987. A description of the interactions of Toll-like receptors, microbes and nutrients.
37. Helmby H, Grencis RK. Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection. Eur J Immunol 2003; 33:2974-2979.