PML-RARα is associated with leptin-receptor induction: The role of mesenchymal stem cell-derived adipocytes in APL cell survival

Blood

Volumn 103, Issue 5, 2004, Pages 1815-1822

  Tabe, Yoko ^b   Konopleva, Marina ^b   Munsell, Mark F ^b   Marini, Frank C ^b   Zompetta, Claudia ^b   McQueen, Teresa ^b   Tsao, Twee ^b   Zhao, Shourong ^b   Pierce, Sherry ^b   Igari, Jun ^b   Estey, Elihu H ^b   Andreeff, Michael ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; STAT3 PROTEIN; CELL SURFACE RECEPTOR; DNA BINDING PROTEIN; ISOPROTEIN; LEPTIN; ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA-RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; RETINOIC ACID RECEPTOR; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TUMOR PROTEIN;

ADIPOCYTE; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL SURVIVAL; COCULTURE; HUMAN; HUMAN CELL; MESENCHYME CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; STEM CELL; BIOSYNTHESIS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CELL STRAIN U937; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ADIPOCYTES; APOPTOSIS; BLOTTING, WESTERN; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; COCULTURE TECHNIQUES; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LEPTIN; LEUKEMIA, PROMYELOCYTIC, ACUTE; MESENCHYMAL STEM CELLS; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION; PROTEIN ISOFORMS; RECEPTORS, CELL SURFACE; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRETINOIN; U937 CELLS; UP-REGULATION;

EID: 1442332329     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-03-0802     Document Type: Article

References (46)

1. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
2. Laharrague P, Larrouy D, Fontanilles AM, et al. High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J. 1998;12:747-752.
3. Umemoto Y, Tsuji K, Yang FC, et al. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood. 1997;90:3438-3443.
4. Cioffi JA, Shafer AW, Zupancic TJ, et al. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med. 1996;2:585-589.
5. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83:1263-1271.
6. Tartaglia L. The leptin receptor. J Biol Chem. 1997;272:6093-6096.
7. Baumann H, Morella KK, White DW, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A. 1996;93:8374-8378.
8. Ghilardi N, Skoda RC. The leptin receptor activates Janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol. 1997;11:393-399.
9. Vaisse C, Halaas JL, Horvath CM, et al. Leptin activation of Stat3 in the hypothalamus of wildtype and ob/ob mice but not db/db mice. Nat Genet. 1996;14:95-97.
10. Konopleva M, Mikhail A, Estrov Z, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood. 1999;93:1668-1676.
11. Estey E, Thall P, Kantarjian H, et al. Association between increased body mass index and a diagnosis of acute promyelocitic leukemia in patients with acute myeloid leukemia. Leukemia. 1997;11:1661-1664.
12. Considine R, Shinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
13. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent; measurements of plasma leptin and OB RNA in obese and weight reduced subjects. Nat Med. 1995;1:1155-1161.
14. Grignani F, Ferrucci PF, Testa U, et al. The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cell. Cells. 1993;74:423-431.
15. Lanotte M, Martin-Thouvenin V, Najman S, et al. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood. 1991;77:1080-1086.
16. Pittenger MF, Alastair MM, Stephen CB, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-147.
17. Tocci A, Forte L. Mesenchymal stem cell: use and perspectives. Hematol J. 2003;4:92-96.
18. Aarskog NK, Vedeler CA. Real-time quantitative polymerase chain reaction: a new method that detects both the peripheral myelin protein 22 duplication in Charcot-Marie-Tooth type 1 A disease and the peripheral myelin protein 22 deletion in hereditary neuropathy with liability to pressure palsies. Hum Genet. 2000;107:494-498.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408.
20. Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med. 1985;103:626-629.
21. Dalton W, Stass SA. A morphologic and cytochemical approach to the diagnosis of acute leukemia. In: Stass SA, ed. The Acute Leukemia: Biologic, Diagnostic, and Therapeutic Determinants. Basel, Switzerland: Marcel Dekker; 1987:27.
22. Cox DR. Regression models and life tables. J R Stat Soc B. 1972;34:187.
23. Kuezmarski RJ, Flegal KM. Criteria for definition of overweight in transition: background and recommendations for the United States. Am J Clin Nutr. 2000;72;1074-1081.
24. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457.
25. Chawla A, Lazar MA. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci U S A. 1994;91:1786-1790.
26. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev. 1998;78:783-809.
27. Russell CD, Ricci MR, Brolin RE, Magill E, Fried SK. Regulation of the leptin content of obese human adipose tissue. Am J Physiol Endocrinol Metab. 2001;280:E399-E404.
28. Sen A, Lea-Currie YR, Sujkowska D, et al. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J Cell Biochem. 2001;81:312-319.
29. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurements of plasma leptin and OB RNA in obese and weight reduced subjects. Nat Med. 1995;1:1155-1161.
30. Takahashi Y, Okimura Y, Mizuno I, et al. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells. J Biol Chem. 1997;272:12897-12900.
31. Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer; class discovery and class prediction by gene expression monitoring. Science. 1999;286:531-537.
32. Bomstein SR, Abu-Asab MA, Glasow A, et al. Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. Diabetes. 2000;49:532-538.
33. Dormady SP, Bashayan O, Dougherty R, Zhang XM, Basch RS. Immortalized multipotential mesenchymal cells and the hematopoietic microenvironment. J Hematother Stern Cell Res. 2001;10:125-140.
34. Ruoslahti E. Fibronectin and its integrin receptors in cancer. Adv Cancer Res. 1999;76:1-20.
35. Friedrich C, Zausch E, Sugrue SP, et al. Hematopoietic supportive functions of mouse bone marrow and fetal liver microenvironment: dissection of granulocyte, B-lymphocyte, and hematopoietic progenitor support at the stromal cell clone level. Blood 1996;87:4596-4606.
36. Takahashi Y, Okimura Y, Mizuno I, et al. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells. J Biol Chem. 1997;272:12897-12900.
37. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000;141:2328-2339.
38. Bjorbaek C, Buchholz RM, Davis SM, et al. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem. 2001;276:4747-4755.
39. Milella M, Kornblau S, Estov Z, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest. 2001;108:851-859.
40. Milella M, Estov Z, Komblau S, et al. Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood. 2002;99:3461-3464.
41. Qiang YW, Kitagawa M, Higashi M, et al. Activation of mitogen-activated protein kinase through α5/β1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells. Exp Hematol. 2000;28:1147-1157.
42. Kawasaki A, Mastumura I, Kataoka Y, et al. Opposing effects of PML and PML/RARα on STAT3 activity. Blood. 2003;101:3668-3673.
43. Dong S, Tweardy DJ. Interactions of STT5b-RARα, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood. 2002;99:2637-2646.
44. Falcone RC, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999;10:105-115.
45. Boise LH, Gonzalez Gm, Postema CE, et al. Bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell. 1993;74:594-607.
46. Konopleva M, Konoplev S, Hu W, et al. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia. 2002;16:1713-1724.