Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4968-4974

  Choi, Mei Y ^a,b   Partridge, Anthony W ^a,b   Daniels, Craig ^a,b   Du, Kai ^a,b   Lukacs, Gergely L ^a,b   Deber, Charles M ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; GROWTH KINETICS; PROTEINS;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); ENDOPLASMIC RETICULUM (ER); HYDROPATHY; MUTANTS;

BIOLOGICAL MATERIALS;

CHLORIDE CHANNEL; MUTANT PROTEIN; PROLINE; SYNTHETIC PEPTIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; MISSENSE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; CELL MEMBRANE; CIRCULAR DICHROISM; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC RETICULUM; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOBLOTTING; IODIDES; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PHENOTYPE; PROLINE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; TIME FACTORS; TRANSFECTION;

EID: 14244262456     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410069200     Document Type: Article

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