Polar mutations in membrane proteins as a biophysical basis for disease

Biopolymers - Peptide Science Section

Volumn 66, Issue 5, 2002, Pages 350-358

  Partridge, Anthony W ^a   Therien, Alex G ^a   Deber, Charles M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

helices; Cystic fibrosis transmembrane conductance regulator; Human disease; Membrane proteins; Molecular defects; Polar mutations; Polar side chain; Transmembrane

Indexed keywords

BILAMINATE MEMBRANES; DISEASES; MUTAGENESIS; PERMITTIVITY; STATISTICAL METHODS;

POLAR MUTATIONS;

PROTEINS;

MEMBRANE PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALPHA HELIX; BIOPHYSICS; CONFERENCE PAPER; CROSS LINKING; CRYSTAL STRUCTURE; DATA BASE; DYNAMICS; HYDROGEN BOND; PHENOTYPE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SPONTANEOUS MUTATION; STEREOSPECIFICITY;

ALLOSTERIC SITE; BINDING SITES; GENETIC DISEASES, INBORN; HUMANS; HYDROGEN BONDING; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 0036996692     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10313     Document Type: Conference Paper

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